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Conjunctival corneal intraepithelial neoplasia (CIN): report of an atypical case

The authors report a case of NIC with atypical presentation and epidemiology as well as its evolution with different modalities of treatment. A forty-one-year-old female was referred to the Department of Cornea and External Diseases complaining about low visual acuity in the right eye and was submitted to complete ophthalmologic examination. The patient presented with corneal epithelial opacities with pseudopodia-like extensions in both eyes. The hypothesis for the case was CCIN and the patient received 3 cycles of topical 0.02% mitomycin C drops 4 times daily for 14 days in the right eye and surgical excision associated with cryotherapy in the left eye. After detection of recurrence of the lesion in the right eye, this lesion was submitted to excision and cryotherapy, which was followed by recurrence. The patient underwent excision and cryotherapy in the right eye once more and there was no recurrence since then. The lesion in the left eye never recurred (3 years of follow-up).

Conjunctival neoplasms; Cornea; Mitomycin C; Cryotherapy


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