Anderson et al.1313. Anderson RA, Bryden C, Agay NA, Chancerelle C, Polansky Y, Roussel MM. Burn-induced alterations of chromium and the glucose/insulin system in rats. Burns. 2006;32:46-51. doi: 10.1016/j.burns.2005.08.005. https://doi.org/10.1016/j.burns.2005.08....
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Demonstrate the role of chromium in response to severe burn |
– |
20% |
– |
3rd degree burn |
Bortolin et al.1414. Bortolin JA, Quintana HT, Tomé TC, Ribeiro FAD, Ribeiro DA, Oliveira F. Burn injury induces histopathological changes and cell proliferation in liver of rats. World J Hepatol. 2016;8(6):322-30. doi: 10.4254/wjh.v8.i6.322. https://doi.org/10.4254/wjh.v8.i6.322...
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Burn injury induces histopathological changes in liver of rats |
10 s 3 s |
30% Dorsal 15% Ventral |
87ºC |
– |
Canhão et al.1515. Canhão AR, Akhtar S, Hammer AM, Morris NL, Javorski MJ, Li X, Kennedy RH, Gamelli RL, Choudhry MA. Effects of mesalamine treatment on gut barrier integrity after burn injury. J Burn Care Res. 2016;1559:283-92. doi: 10.1097/BCR.0000000000000396. https://doi.org/10.1097/BCR.000000000000...
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Effects of mesalamine treatment on gut barrier integrity after burn injury |
7 s 9 s |
20% |
85ºC 95°C |
Full thickness 3rd degree burn |
Li et al.1616. Li H1, Yin J, Zhang Z, Winston JH, Shi XZ, Chen JD. Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats. Neurogastroenterol Motil. 2016;29(1);36-42. doi: 10.1111/nmo.12693. https://doi.org/10.1111/nmo.12693...
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Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats |
10 s 3 s |
60% Dorsal Ventral |
95°C |
3rd degree burn |
Ida et al.1717. Ida T, Iwazaki H, Kawaguchi Y, Kawauchi S, Ohkura T, Iwaya K, Tsuda H, Saitoh D, Sato S, Iwai T. Burn depth assessments by photoacoustic imaging and laser Doppler imaging. Wound Rep Reg. 2016;24:349–55. doi: 10.1111/wrr.12374. https://doi.org/10.1111/wrr.12374...
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Burn depth assessments by photoacoustic imaging and laser Doppler imaging |
10 s |
4×10cm2 Dorsal |
70ºC, 78ºC, 83ºC, 88ºC, 93ºC, 98ºC |
Superficial dermal burn, deep dermal burn, and deep burn |
Hoscheit et al.1818. Hoscheit M, Conner G, Roemer J, Vuckovska A, Abbasnia P, Vana P. Burn injury has skeletal site-specific effects on bone integrity and markers of bone remodeling. J Burn Care Res. 2016;37(6):367–78. doi: 10.1097/BCR.0000000000000389. https://doi.org/10.1097/BCR.000000000000...
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Burn injury has skeletal site-specific effects on bone integrity and markers of bone remodeling |
30 s |
30% Dorsal |
100ºC |
4th degree burn |
Mesquita et al.1919. Mesquita RL, Silva PIC, Sawaki SH, Oliveira K, Fontes-Pereira AJ, Silva-Freitas JJ, Albuquerque-Pereira WCI, Kietzer KC. Effect of low-intensity therapeutic ultrasound on wound healing in rats subjected to third degree burns. Acta Cir Bras. 2016;31(1):36-43. doi: 10.1590/S0102-865020160010000006. https://doi.org/10.1590/S0102-8650201600...
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Effect of low-intensity therapeutic ultrasound on wound healing in rats subjected to third degree burns |
10 s |
30% Dorsal |
100ºC |
3rd degree burn |
Vana et al.2020. Vana PG, LaPorte HM, Wong YM, Kennedy RH, Gamelli RL, Majetschak M. Proteasome inhibition after burn injury. J Burn Care Res. 2016;37(4):207–15. doi: 10.1097/BCR.0000000000000280. https://doi.org/10.1097/BCR.000000000000...
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Proteasome inhibition after burn injury |
17 s |
30-40% dorsal |
Boiling water |
4th degree burn |
Tian et al.2121. Tian M, Qing C, Niu Y, Dong J, Cao X, Song F, Ji X, Lu S. The relationship between inflammation and impaired wound healing in a diabetic rat burn model. J Burn Care Res. 2016;47:115-24. doi: 10.1097/BCR.0000000000000171. https://doi.org/10.1097/BCR.000000000000...
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The relationship between inflammation and impaired wound healing in a diabetic rat burn model |
8 s |
10% Dorsal |
70ºC |
2nd degree burn |
Wiggins-Dohlvik et al.2222. Wiggins-Dohlvik K, Oakley RP, Han MS, Stagg HW, Alluri H, Shaji CA, Davis ML, Tharakan B. Binu Tharakan. Tissue inhibitor of metalloproteinase-2 inhibits burn-induced derangements and hyperpermeability in microvascular endothelial cells. Am J Surg. 2016;211:197-205. doi: 10.1016/j.amjsurg.2015.08.016. https://doi.org/10.1016/j.amjsurg.2015.0...
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Investigate microvascular abnormalities and changes in permeability associated with burn trauma |
30% dorsal |
10s |
100ºC |
– |
Al-Roujayee2323. Al-Roujayee AS. Naringenin improves the healing process of thermally-induced skin damage in rats. J Inter Med Res. 2017;45:570-82. doi: 10.1177/0300060517692483. https://doi.org/10.1177/0300060517692483...
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Evaluate the effect of the phenolic compound naringenin on thermal burn-induced inflammatory responses and oxidative stress |
10 s |
20% Area: 6cm2
|
90ºC |
1st degree burns with partial skin injury |
Koami et al.2424. Koami K, SakamotoY, Miyasho T, Noguchi R, Sato N, Kai K, Yamada KC, Inoue S. Haptoglobin reduces inflammatory cytokine INF-γ and facilitates clot formation in acute severe burn rat model. J Nippon Med Sch. 2017;84(2):64-72. doi: 10.1272 / jnms.84.64. https://doi.org/10.1272/jnms.84.64...
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Haptoglobin reduces inflammatory cytokine INF-γ and facilitates clot formation in acute severe burn model |
– |
30% Dorsal |
– |
4th degree burn |
Wiggins-Dohlvik; Tharakan2525. Wiggins-Dohlvik K, Tharakan B. A rat burn injury model for studying changes in microvascular permeability. Humana Press Inc. 2018;1717:93-100. doi: 10.1007 / 978-1-4939-7526-6_8. https://doi.org/10.1007/978-1-4939-7526-...
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A rat burn injury model for studying changes in microvascular permeability |
10 s |
30% |
100°C |
– |
Ida et al.2626. Ida T, Iwazaki H, Omuro T, Kawaguchi Y, Tsunoi Y, Kawauchi S, Sato S. Lensless high-resolution photoacoustic imaging scanner for in vivo skin imaging. Opt Rev. 2018;25:33-9. doi: 10.1007/s10043-017-0384-1. https://doi.org/10.1007/s10043-017-0384-...
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Lensless high-resolution photoacoustic imaging scanner for in vivo skin imaging |
– |
– |
– |
Deep dermal burn and deep burn |