The authors present a model of experimental vídeolaparoscopy to evaluate the hepatotoxicity induced by carbon tetrachloride (CCl4) in rats. Nodules in hepatic surface and significative increase of hepatobiliar function tests (alanine aminotransferase, aspartate aminotransferase, alkaline phosphastase, and gammaglutamyltranspeptidase) were observed in rats treated with CCl4. Furthermore, liver cirrhosis was diagnosed by histopathologic study in all rats submitted to administration of CCl4. In this manner, experimental vídeolaparoscopy in rats seems be a excelent diagnostic method that merits further investigation to explore the physiologic consequences of laparoscopic surgery.
Laparoscopy; Liver cirrhosis; Carbon tetrachloride; Rats
