<b><i>Chenopodium ambrosioides</i></b> L. extract prevents bone loss

Twelve rats were subjected to bilateral ovariectomy for inducing osteoporosis. After surgery, they were divided into two groups: Ovariectomy-control group (G1, n=6), receiving 0.5 ml distilled water by gavage for 30 days, and Ovariectomy plus mastruz group (G2, n=6), receiving 0.5 ml of the hydroalcoholic extract of mastruz at 10% concentration (50mg) daily, for the same period. Then, the blood of the animals was collected for further biochemical analysis (liver function) and tibia and liver were removed for histological and histomorphometric analyses.

RESULTS:

The cortical bone was significantly larger in the G2 than G1, whereas G1 presented the highest amount of adipocytes in the bone marrow (p<0.05). The blood levels of aspartate aminotransferase, triglycerides and cholesterol were significantly higher, whereas globulin and lactate dehydrogenase were smaller in G2 than G1.

CONCLUSION:

The hydroalcoholic extract of mastruz has effects on bone metabolism by changing blood proteins and enzymes and preventing both bone loss and the substitution of bone marrow cells by

Key words:
Chenopodium ambrosioides; Ovariectomy; Rats

Parameter	Ovariectomy (Control group)	Ovariectomy plus mastruz	P value
Aspartate aminotransferase (U/L)	132.2 ± 15.61	246.2 ± 33.19	0.0111*
Globulin (g/dL)	4.470 ± 0.2720	1.783 ± 0.1869	<0.0001*
Lactate dehydrogenase (U/L)	2539 ± 754.3	602.7 ± 36.42	0.0282*
Alkaline phosphatase	203.6 ± 7.80	163.6 ± 26.00	0.1788
Glucose (mg/dL)	147.0 ± 13.63	110.2 ± 12.31	0.0727
Triglycerides (mg/dL)	24.33 ± 1.764	57.17 ± 2.455	<0.0001*
Cholesterol (mg/dL)	67.50 ± 5.340	84.67 ± 4.088	0.0287*
Calcium (mg/dL)	9.917 ± 0.63	9.983 ± 0.19	0.8104
Phosphorus (mg/dL)	14.57 ± 2.68	9.133 ± 0.39	0.0732
Magnesium (mg/dL)	3.333 ± 0.32	2.883 ± 0.12	0.2256

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
E-mail: actacirbras@gmail.com

Acompanhe os números deste periódico no seu leitor de RSS

[1] Correspondence: Márcia Martins Marques Faculdade de Odontologia-Universidade de São Paulo Avenida Professor Lineu Prestes, 2227 05508-000 São Paulo - SP Brasilmmmarques@usp.br

Brasil

Brasil

Chenopodium ambrosioides L. extract prevents bone loss 1 1 Research performed at Laboratory of Pathology, Universidade Potiguar (UnP), Natal-RN, Brazil.

ABSTRACT

PURPOSE:

METHODS:

RESULTS:

CONCLUSION:

Chenopodium ambrosioides L. extract prevents bone loss ^¹ 1 Research performed at Laboratory of Pathology, Universidade Potiguar (UnP), Natal-RN, Brazil.