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An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation1 1 Research performed at Experimental Animal Unit, Porto Alegre Clinics Hospital, Porto Alegre-RS, Brazil. Part of Master degree thesis, Postgraduate Program in Medicine: Surgical Sciences, Rio Grande do Sul Federal University (UFRGS). Tutor: Sady Selaimen da Costa.

PURPOSE:

Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits.

METHODS:

In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa.

RESULTS:

Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026).

CONCLUSION:

It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.

Sinusitis; Disease Models, Animal; Models, Animal; Maxillary Sinusitis; Rabbits


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