Non heart beating organ donor: new experimental model in pigs

Doador de coração parado: novo modelo experimental em suínos

Lúcio Kenny Morais Pedro Moraes da Silva Júnior Juan Carlos Duke Moreno Andressa Machado Santana Brasil João Paulo Figueiredo Camarço Sarah Barboza Martins Claudemiro Quireze Júnior About the authors

PURPOSE: To describe technical aspects of a new experimental model that simulates a non heart beating organ donor. METHODS: Landrace pigs were operated on and cardiac arrest was obtained by means of myocardial infarction and interruption of ventilator support. RESULTS: Mean cardiac frequency, systolic and diastolic blood pressure levels, central venous pressure, oxygen saturation and concentration of expired CO2 dropout occurred at seven minutes after cardiac arrest. CONCLUSION: The procedure was easily reproduced and a homogeneous circulatory failure could de obtained by the end of seven minutes. The model is suitable for further studies regarding abdominal organ transplantation.

Transplantation; Models, Animal; Experimental Development; Heart Arrest; Swine


Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Al. Rio Claro, 179/141, 01332-010 São Paulo SP Brazil, Tel./Fax: +55 11 3287-8814 - São Paulo - SP - Brazil
E-mail: sgolden@terra.com.br