PURPOSE: To study the copaiba oil effect in rats' aminotrasnferases submited to hepatic ischemic and reperfusion with and without preconditioning. METHODS: 24 male and adults rats (Rattus norvegicus albinus,Wistar) were distributed into six groups: Standard Group (SG); Copaiba Group (CG), Ischemic-reperfusion Group (IRG), Ischemic-reperfusion + Copaiba Group (IRCG), Ischemic Preconditioning Group (IPCG) and Ischemic Preconditioning + Copaiba Group (IPCCG). The animals of CG, IRCG and IPCCG received copaiba oil, 0,63ml/kg/day by gavage, during 7 days. It was realized total hepatic ischemic by 30 minutes and, in animals subbimited to ischemic preconditioning, it was realized 10 minutes of ischemia, following by 5 minutes of reperfusion and other ischemia by 30 minutes. All animals were subbmited to 24 hours of reperfusion. To realalize surgery procedure, animals were anesthezied through ethilic eter breathing. On first post-operating day, blood was collected to dose aminotrasferases. RESULTS: It was not observe alterations in AST level in animals which received copaiba oil. There was no statistic difference between IRCG and IRG ALT levels, however, this enzime was increased in IPCCG when compared with IPCG. CONCLUSION: Copaiba oil did not change AST levels in groups studied. Analysing ALT, this oil did not change its values in animais were realized just hepatic ischemic-reperfusion, however, it had levels increase in IPCCG when compared to IPCG. Between IRCG and IPCCG, ALT levels were not statistical different.
Ischemic preconditioning; Ischemic-reperfusion; Liver; Medicinal plants; Rats
