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Efeitos analgésico e hipnótico das associações do sufentanil com o tiopental e com o propofol, em ratos

Antonio Mauro Vieira Djalma José Fagundes Félix Carlos Ocáriz Bazano Eduardo Chibeni Fernandes Ramos About the authors

The aim of this study was to evaluate the interactions of the analgesic action of sufentanil with the hypnotic action of thiopental and propofol, in 60 male rats distributed in two groups of 30 and submitted to different doses of sufentanil and propofol, to determine the analgesic (AMD) and hypnotic medium doses (HMD). The AMD of sufentanil was the analgesic dose and HMD of thiopental and propofol was the dose to obtain hypnosis, this is, the lost of righting reflex. There was a prolonged hypnotic action when thiopental with sufentanil and propofol with sufentanil were used together. The analgesic action of sufentanil-thiopental association has a significant increase, and sufentanil-propofol association showed no significant difference when compared to sufentanil alone. The sufentanil-thiopental association had more analgesic and hypnotic action when compared to sufentanil-propofol association. When was compared the concomitant presence of analgesy and hypnosis, the sufentanil-thiopental association had a longer lasting.

Interaction drugs; Propofol; Rats; Sufentanil; Thiopental

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia - São Paulo - SP - Brazil