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Rutin ameliorates methotrexate induced hepatic injury in rats1 1 Research performed at Laboratory of Animal Unit, Gulhane Military Medical Academy, Ankara, Turkey.

PURPOSE:

To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats.

METHODS:

Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum.

RESULTS:

Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx +Rutin group. Serum AST levels were similar among the groups.

CONCLUSION:

Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.

Methotrexate; Rutin; Drug Effects; Liver; Rats


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