Cell of origin88 Valatkaitė E, Baušytė R, Vitkevičienė A, Ramašauskaitė D, Navakauskienė R. Decidualization potency and epigenetic changes in human endometrial origin stem cells during propagation. Front Cell Dev Biol. 2021;9:765265. http://dx.doi.org/10.3389/fcell.2021.765265. PMid:34869358. http://dx.doi.org/10.3389/fcell.2021.765...
9 Mutsaers SE. The mesothelial cell. Int J Biochem Cell Biol. 2004;36(1):9-16. http://dx.doi.org/10.1016/S1357-2725(03)00242-5. PMid:14592528. http://dx.doi.org/10.1016/S1357-2725(03)...
10 Turner S, Elston DM. Malignant melanoma. Medscape. 2002;98:50-2.-1111 Gonzalez RS. Colon carcinoma signet ring cell carcinoma. PathologyOutlines.com; 2021. p. 1-4. |
Mesenchymal stem cells |
Mesoderm |
Neural crest cells |
Epithelium |
Most common site affected1212 Kinra P, Sen A, Sharma J. Ectopic decidual reaction: a case report. Med J Armed Forces India. 2006;62(3):280-1. http://dx.doi.org/10.1016/S0377-1237(06)80022-5. PMid:27407910. http://dx.doi.org/10.1016/S0377-1237(06)...
13 Ordóñez NG. Deciduoid mesothelioma: report of 21 cases with review of the literature. Mod Pathol. 2012;25(11):1481-95. http://dx.doi.org/10.1038/modpathol.2012.105. PMid:22684220. http://dx.doi.org/10.1038/modpathol.2012...
14 Damsky WE Jr, Rosenbaum LE, Bosenberg M. Decoding melanoma metastasis. Cancers. 2010;3(1):126-63. http://dx.doi.org/10.3390/cancers3010126. PMid:24212610. http://dx.doi.org/10.3390/cancers3010126...
-1515 Mandzhieva B, Jalil A, Nadeem M, Hasan SA, Jain AG. Most common pathway of metastasis of rectal signet ring cell carcinoma to the skin: hematogenous. Cureus. 2020;12(2):e6890. http://dx.doi.org/10.7759/cureus.6890. PMid:32190453. http://dx.doi.org/10.7759/cureus.6890...
|
Ovaries |
Peritoneum |
Lung |
Liver |
Gender affected22 Fair KP, Patterson JW, Murphy RJ, Rudd RJ. Cutaneous deciduosis. J Am Acad Dermatol. 2000;43(1):102-7. http://dx.doi.org/10.1067/mjd.2000.100962. PMid:10863233. http://dx.doi.org/10.1067/mjd.2000.10096...
,1616 Karst EP, von Oiste DD. Mesothelioma cancer rates in men vs women. Mesothelioma (2020 apr. 21): 1-8.
17 Wyant T, Alteri R, Kalidas M, Ogoro C, Lubejko B, Eidsmoe K. Key statistics for melanoma skin cancer. Kennesaw: American Cancer Society; 2022. p. 2-3 [cited 2022 Mar 11]. Available from: https://www.cancer.org/%0Acancer/melanoma-skin-cancer/about/key-statistics.html https://www.cancer.org/%0Acancer/melanom...
-1818 Wu J, Fang D, Man D, et al. Clinical correlates and prognostic value of different metastatic sites in gastric and colorectal signet ring cell carcinoma. Engineering. 2020;6(9):1028-34. http://dx.doi.org/10.1016/j.eng.2020.06.007. http://dx.doi.org/10.1016/j.eng.2020.06....
|
Females |
Males |
Males |
Males |
Age group most commonly affected22 Fair KP, Patterson JW, Murphy RJ, Rudd RJ. Cutaneous deciduosis. J Am Acad Dermatol. 2000;43(1):102-7. http://dx.doi.org/10.1067/mjd.2000.100962. PMid:10863233. http://dx.doi.org/10.1067/mjd.2000.10096...
,1010 Turner S, Elston DM. Malignant melanoma. Medscape. 2002;98:50-2.,1313 Ordóñez NG. Deciduoid mesothelioma: report of 21 cases with review of the literature. Mod Pathol. 2012;25(11):1481-95. http://dx.doi.org/10.1038/modpathol.2012.105. PMid:22684220. http://dx.doi.org/10.1038/modpathol.2012...
,1919 Santos C, Gamboa F, Fradinho F, Pêgo A, Carvalho L, Bernardo J. Mesotelioma deciduóide pleural: uma entidade rara numa mulher jovem. Rev Port Pneumol. 2012;18(6):294-8. http://dx.doi.org/10.1016/j.rppneu.2012.02.004. PMid:22424699. http://dx.doi.org/10.1016/j.rppneu.2012....
,2020 Franko J, Le VH, Tee MC, et al. Signet ring cell carcinoma of the gastrointestinal tract: national trends on treatment effects and prognostic outcomes. Cancer Treat Res Commun. 2021;29:100475. http://dx.doi.org/10.1016/j.ctarc.2021.100475. PMid:34655861. http://dx.doi.org/10.1016/j.ctarc.2021.1...
|
Reproductive age (20-40 years) |
5th – 6th decade |
5th decade and older |
6th decade |
Morphology22 Fair KP, Patterson JW, Murphy RJ, Rudd RJ. Cutaneous deciduosis. J Am Acad Dermatol. 2000;43(1):102-7. http://dx.doi.org/10.1067/mjd.2000.100962. PMid:10863233. http://dx.doi.org/10.1067/mjd.2000.10096...
,1111 Gonzalez RS. Colon carcinoma signet ring cell carcinoma. PathologyOutlines.com; 2021. p. 1-4.,1919 Santos C, Gamboa F, Fradinho F, Pêgo A, Carvalho L, Bernardo J. Mesotelioma deciduóide pleural: uma entidade rara numa mulher jovem. Rev Port Pneumol. 2012;18(6):294-8. http://dx.doi.org/10.1016/j.rppneu.2012.02.004. PMid:22424699. http://dx.doi.org/10.1016/j.rppneu.2012....
,2121 Sorokin P, Nikiforchin A, Panin A, Zhukov A, Gushchin V, Kurtser M. Diffuse ectopic deciduosis imitating peritoneal carcinomatosis with acute abdomen presentation: a case report and literature review. Case Rep Obstet Gynecol. 2020;2020:8847082. http://dx.doi.org/10.1155/2020/8847082. PMid:33062356. http://dx.doi.org/10.1155/2020/8847082...
,2222 Murray CA, Leong WL, McCready DR, Ghazarian DM. Histopathological patterns of melanoma metastases in sentinel lymph nodes. J Clin Pathol. 2004;57(1):64-7. http://dx.doi.org/10.1136/jcp.57.1.64. PMid:14693838. http://dx.doi.org/10.1136/jcp.57.1.64...
|
Decidualized stromal cells are polygonal, oval to spindle shaped cells with large nuclei and abundant eosinophilic cytoplasm |
Malignant dyscohesive large epithelioid cells, eosinophilic cytoplasm, large round nuclei |
Large epithelioid or spindle shaped, mixed cytological morphology, macro nucleoli |
Signet ring cells with intracellular and extracellular mucin |
Immunohistochemical features22 Fair KP, Patterson JW, Murphy RJ, Rudd RJ. Cutaneous deciduosis. J Am Acad Dermatol. 2000;43(1):102-7. http://dx.doi.org/10.1067/mjd.2000.100962. PMid:10863233. http://dx.doi.org/10.1067/mjd.2000.10096...
,1111 Gonzalez RS. Colon carcinoma signet ring cell carcinoma. PathologyOutlines.com; 2021. p. 1-4.,1212 Kinra P, Sen A, Sharma J. Ectopic decidual reaction: a case report. Med J Armed Forces India. 2006;62(3):280-1. http://dx.doi.org/10.1016/S0377-1237(06)80022-5. PMid:27407910. http://dx.doi.org/10.1016/S0377-1237(06)...
,2121 Sorokin P, Nikiforchin A, Panin A, Zhukov A, Gushchin V, Kurtser M. Diffuse ectopic deciduosis imitating peritoneal carcinomatosis with acute abdomen presentation: a case report and literature review. Case Rep Obstet Gynecol. 2020;2020:8847082. http://dx.doi.org/10.1155/2020/8847082. PMid:33062356. http://dx.doi.org/10.1155/2020/8847082...
,2222 Murray CA, Leong WL, McCready DR, Ghazarian DM. Histopathological patterns of melanoma metastases in sentinel lymph nodes. J Clin Pathol. 2004;57(1):64-7. http://dx.doi.org/10.1136/jcp.57.1.64. PMid:14693838. http://dx.doi.org/10.1136/jcp.57.1.64...
|
Vimentin, ER, PR, Desmin, CD 30 and CD 10 positivity |
Cytokeratin (CK) MNF116, HBME-1 and Calretinin positivity |
S100, HMB-45 positivity |
CK20, CDX2, MUC2, MUC5AC positivity, variable MUC1 positivity |
Association with occupational exposure2323 Fortarezza F, Della Barbera M, Pezzuto F, et al. Diagnostic challenges in epithelioid pleural mesothelioma: case series with support from electron microscopy. Diagnostics. 2021;11(5):1-7. http://dx.doi.org/10.3390/diagnostics11050841. PMid:34067170. http://dx.doi.org/10.3390/diagnostics110...
,2424 Fritschi L, Siemiatycki J. Melanoma and occupation: results of a case-control study. Occup Environ Med. 1996;53(3):168-73. http://dx.doi.org/10.1136/oem.53.3.168. PMid:8704857. http://dx.doi.org/10.1136/oem.53.3.168...
|
Not associated |
Occupational exposure to asbestos |
Not associated |
Not associated |