Years
Age Range
0-17 years
18-40 years
41-59 years
≥60 years
PK
2004
Mean level (ng/mL)
33.0
28.5 ± 12.1
25.7 ± 10.4
22.9 ± 9.9
0.197
Deficient (n/%)
0 (0.0)
5 (20.8)
5 (31.2)
37 (78.7)
Sufficient (n/%)
1 (100.0)
18 (75.0)
11 (68.8)
10 (21.3)
≥60 to 100 (n/%)
0 (0.0)
1 (4.2)
0 (0.0)
0 (0.0)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
2005
Mean level (ng/mL)
25.8
26.5 ± 10.7
24.6 ± 10.5
25.3 ± 10.1
0.863
Deficient (n/%)
0 (0.0)
6 (31.6)
16 (38.1)
34 (70.8)
Sufficient (n/%)
1 (100.0)
13 (68.4)
26 (61.9)
13 (27.1)
≥60 to 100 (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
1 (2.1)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
2006
Mean level (ng/mL)
28.0 ± 0.0
27.4 ± 8.7
26.6 ± 10.5
23.8 ± 9.7
0.177
Deficient (n/%)
0 (0.0)
5 (23.8)
15 (27.8)
42 (73.7)
Sufficient (n/%)
2 (100.0)
16 (76.2)
39 (72.2)
15 (26.3)
≥60 to 100 (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
2007
Mean level (ng/mL)
32.0 ± 8.4
24.4 ± 9.5
23.4 ± 11.0
24.0 ± 16.9
0.053
Deficient (n/%)
0 (0.0)
11 (36.7)
32 (47.8)
68 (74.7)
Sufficient (n/%)
8 (100.0)
19 (63.3)
34 (50.7)
20 (22.0)
≥60 to 100 (n/%)
0 (0.0)
0 (0.0)
1 (1.5)
1 (1.1)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
2 (2.2)
2008
Mean level (ng/mL)
28.7 ± 11.0
24.7 ± 12.0
21.0 ± 9.2
20.6 ± 9.1
<0.001
Deficient (n/%)
5 (26.3)
40 (41.2)
103 (49.8)
212 (84.5)
Sufficient (n/%)
14 (73.7)
56 (57.7)
104 (50.2)
37 (14.7)
≥60 to 100 (n/%)
0 (0.0)
1 (1.0)
0 (0.0)
1 (0.4)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
1 (0.4)
2009
Mean level (ng/mL)
27.0 ± 11.5
27.7 ± 15.2
27.0 ± 13.3
24.4 ± 14.2
0.002
Deficient (n/%)
8 (38.1)
35 (32.7)
95 (31.0)
345 (73.7)
Sufficient (n/%)
13 (61.9)
67 (62.6)
207 (67.6)
110 (23.5)
≥60 to 100 (n/%)
0 (0.0)
5 (4.7)
3 (1.0)
11 (2.4)
Intoxication (n/%)
0 (0.0)
0 (0.0)
1 (0.3)
2 (0.4)
2010
Mean level (ng/mL)
26.0 ± 10.3
26.5 ± 14.4
24.0 ± 11.6
23.1 ± 14.1
<0.001
Deficient (n/%)
12 (24.5)
135 (39.5)
402 (42.1)
1,074 (80.2)
Sufficient (n/%)
36 (73.5)
197 (57.6)
541 (56.6)
237 (17.7)
≥60 to 100 (n/%)
1 (2.0)
9 (2.6)
11 (1.2)
24 (1.8)
Intoxication (n/%)
0 (0.0)
1 (0.3)
2 (0,2)
4 (0.3)
2011
Mean level (ng/mL)
26.4 ± 7.8
25.4 ± 9.9
24.9 ± 9.5
23.4 ± 10.2
<0.001
Deficient (n/%)
56 (21.3)
461 (28.7)
1,132 (30.6)
3,827 (79.8)
Sufficient (n/%)
207 (78.7)
1,138 (70.9)
2,555 (69.0)
941 (19.6)
≥60 to 100 (n/%)
0 (0.0)
5 (0.3)
12 (0.3)
14 (0.3)
Intoxication (n/%)
0 (0.0)
2 (0.1)
5 (0.1)
13 (0.3)
2012
Mean level (ng/mL)
26.1 ± 8.0
24.0 ± 8.0
23.2 ± 7.8
22.2 ± 8.9
<0.001
Deficient (n/%)
151 (20.5)
1,244 (32.2)
2,354 (34.7)
5,878 (84.8)
Sufficient (n/%)
582 (79.2)
2,613 (67.6)
4,421 (65.2)
1,034 (14.9)
≥60 to 100 (n/%)
2 (0.3)
5 (0.1)
7 (0.1)
17 (0.2)
Intoxication (n/%)
0 (0.0)
2 (0.1)
2 (0.0)
6 (0.1)
2013
Mean level (ng/mL)
25.9 ± 7.4
24.7 ± 8.3
23.6 ± 7.6
23.0 ± 8.6
<0.001
Deficient (n/%)
359 (20.1)
2,058 (28.4)
3,043 (31.9)
6,426 (82.3)
Sufficient (n/%)
1,421 (79.7)
5,173 (71.4)
6,474 (67.9)
1,352 (17.3)
≥60 to 100 (n/%)
2 (0.1)
16 (0.2)
14 (0.1)
19 (0.2)
Intoxication (n/%)
0 (0.0)
2 (0.0)
6 (0.1)
8 (0.1)
2014
Mean level (ng/mL)
29.0 ± 8.6
28.9 ± 9.3
28.3 ± 9.0
28.3 ± 9.7
<0.001
Deficient (n/%)
320 (11.7)
1,287 (14.0)
1,417 (14.8)
4,408 (61.4)
Sufficient (n/%)
2,411 (87.8)
7,816 (85.2)
8,082 (84.5)
2,712 (37.8)
≥60 to 100 (n/%)
14 (0.5)
68 (0.7)
57 (0.6)
52 (0.7)
Intoxication (n/%)
0 (0.0)
7 (0.1)
10 (0.1)
9 (0.1)
2015
Mean level (ng/mL)
29.5 ± 8.7
29.1 ± 9.5
28.7 ± 9.1
28.7 ± 10.0
<0.001
Deficient (n/%)
355 (10.3)
1,427 (13.7)
1,277 (13.5)
4,189 (59.4)
Sufficient (n/%)
3,066 (89.1)
8,877 (85.4)
8,143 (85.9)
2,800 (39.7)
≥60 to 100 (n/%)
19 (0.6)
82 (0.8)
44 (0.5)
53 (0.8)
Intoxication (n/%)
0 (0.0)
12 (0.1)
17 (0.2)
11 (0.2)
2016
Mean level (ng/mL)
30.1 ± 10.0
28.9 ± 9.9
28.8 ± 9.6
28.8 ± 10.1
<0.001
Deficient (n/%)
350 (10.7)
1,497 (15.3)
1,080 (13.4)
3,807 (60.9)
Sufficient (n/%)
2,876 (88.3)
8,196 (83.8)
6,915 (85.7)
2,381 (38.1)
≥60 to 100 (n/%)
28 (0.9)
80 (0.8)
55 (0.7)
59 (0.9)
Intoxication (n/%)
4 (0.1)
13 (0.1)
16 (0.2)
4 (0.1)
2017
Mean level (ng/mL)
32.2 ± 8.2
29.0 ± 10.4
29.3 ± 9.7
29.5 ± 9.5
<0.001
Deficient (n/%)
118 (3.9)
882 (9.6)
640 (8.8)
2,921 (51.9)
Sufficient (n/%)
2,910 (95.3)
8,272 (90.0)
6,615 (90.7)
2,671 (47.5)
≥60 to 100 (n/%)
23 (0.8)
23 (0.3)
33 (0.5)
25 (0.4)
Intoxication (n/%)
2 (0.1)
14 (0.2)
9 (0.1)
7 (0.1)
2018
Mean level (ng/mL)
31.4 ± 8.9
27.9 ± 9.9
28.5 ± 13.1
29.9 ± 58.3
<0.001
Deficient (n/%)
176 (6.2)
1,117 (13.5)
752 (11.9)
2,953 (59.4)
Sufficient (n/%)
2,629 (93.1)
7,120 (86.0)
5,540 (87.5)
1,975 (39.7)
≥60 to 100 (n/%)
19 (0.7)
32 (0.4)
29 (0.5)
38 (0.8)
Intoxication (n/%)
0 (0.0)
11 (0.1)
8 (0.1)
9 (0.2)
Total
Mean level (ng/mL)
29.7 ± 9.0
27.9 ± 9.7
27.0 ± 9.8
26.4 ± 20.4
<0.001
Deficient (n/%)
1,910 (10.5)
10,210 (17.0)
12,363 (19.8)
36,221 (68.4)
Sufficient (n/%)
16,177 (88.9)
49,591 (82.4)
49,707 (79.6)
16,308 (30.8)
≥60 to 100 (n/%)
108 (0.6)
327 (0.5)
266 (0.4)
315 (0.6)
Intoxication (n/%)
6 (0.0)
64 (0.1)
76 (0.1)
76 (0.1)
k
Years
<60 years
≥60 years
Female
Male
PM
Female
Male
PM
2004
Mean level (ng/mL)
28.4 ± 11.4
20.7 ± 8.8
0.152
22.9 ± 10.1
23.0 ± 9.1
0.799
Deficient (n/%)
8 (22.2)
2 (40.0)
33 (80.5)
4 (66.7)
Sufficient (n/%)
27 (75.0)
3 (60.0)
8 (19.5)
2 (33.3)
≥60 to 100 (n/%)
1 (2.8)
0 (0.0)
0 (0.0)
0 (0.0)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
2005
Mean level (ng/mL)
25.1 ± 10.6
25.9 ± 10.1
0.941
25.0 ± 10.4
29.5 ± 4.4
0.201
Deficient (n/%)
19 (35.2)
3 (37.5)
32 (71.1)
2 (66.7)
Sufficient (n/%)
35 (64.8)
5 (62.5)
12 (26.7)
1 (33.3)
≥60 to 100 (n/%)
0 (0.0)
0 (0.0)
1 (2.2)
0 (0.0)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
2006
Mean level (ng/mL)
26.8 ± 8.7
27.1 ± 13.5
0.674
24.3 ± 10.2
20.8 ± 5.5
0.490
Deficient (n/%)
14 (23.0)
6 (37.5)
35 (71.4)
7 (87.5)
Sufficient (n/%)
47 (77.0)
10 (62.5)
14 (28.6)
1 (12.5)
≥60 to 100 (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
Intoxication (n/%)
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
2007
Mean level (ng/mL)
24.0 ± 10.4
25.6 ± 11.2
0.582
24.2 ± 17.2
21.7 ± 14.0
0.613
Deficient (n/%)
34 (40.0)
9 (45.0)
63 (75.0)
5 (71.4)
Sufficient (n/%)
50 (58.8)
11 (55.0)
18 (21.4)
2 (28.6)
≥60 to 100 (n/%)
1 (1.2)
0 (0.0)
1 (1.2)
0 (0.0)
Intoxication (n/%)
0 (0.0)
0 (0.0)
2 (2.4)
0 (0.0)
2008
Mean level (ng/mL)
22.1 ± 10.2
25.7 ± 11.7
0.041
20.3 ± 8.8
22.7 ± 11.1
0.356
Deficient (n/%)
130 (46.9)
18 (39.1)
191 (86.4)
21 (70.0)
Sufficient (n/%)
147 (53.1)
27 (58.7)
28 (12.7)
9 (30.0)
≥60 to 100 (n/%)
0 (0.0)
1 (2.2)
1 (0.5)
0 (0.0)
Intoxication (n/%)
0 (0.0)
0 (0.0)
1 (0.5)
0 (0.0)
2009
Mean level (ng/mL)
26.9 ± 13.7
29.1 ± 13.8
0.205
24.0 ± 14.2
27.2 ± 14.1
0.047
Deficient (n/%)
122 (32.4)
16 (28.1)
302 (74.6)
43 (68.3)
Sufficient (n/%)
248 (65.8)
39 (68.4)
92 (22.7)
18 (28.6)
≥60 to 100 (n/%)
6 (1.6)
2 (3.5)
9 (2.2)
2 (3.2)
Intoxication (n/%)
1 (0.3)
0 (0.0)
2 (0.5)
0 (0.0)
2010
Mean level (ng/mL)
24.4 ± 12.0
26.5 ± 14.9
0.051
22.9 ± 13.9
24.5 ± 14.8
0.054
Deficient (n/%)
491 (41.5)
58 (35.2)
913 (81.0)
161 (75.9)
Sufficient (n/%)
669 (56.6)
105 (63.6)
190 (16.9)
47 (22.2)
≥60 to 100 (n/%)
20 (1.7)
1 (0.6)
21 (1.9)
3 (1.4)
Intoxication (n/%)
2 (0.2)
1 (0.6)
3 (0.3)
1 (0.5)
2011
Mean level (ng/mL)
24.8 ± 9.3
26.7 ± 10.5
<0.001
23.1 ± 10.3
24.9 ± 9.4
<0.001
Deficient (n/%)
1,445 (30.9)
204 (22.6)
3,232 (81.0)
595 (74.1)
Sufficient (n/%)
3,206 (68.6)
694 (77.0)
737 (18.5)
204 (25.4)
≥60 to 100 (n/%)
15 (0.3)
2 (0.2)
10 (0.3)
4 (0.5)
Intoxication (n/%)
6 (0.1)
1 (0.1)
13 (0.3)
0 (0.0)
2012
Mean level (ng/mL)
23.4 ± 7.9
24.5 ± 7.9
<0.001
21.9 ± 8.9
23.2 ± 9.0
<0.001
Deficient (n/%)
3,106 (33.8)
643 (29.5)
4,656 (85.6)
1,222 (81.7)
Sufficient (n/%)
6,082 (66.1)
1,534 (70.3)
765 (14.1)
269 (18.0)
≥60 to 100 (n/%)
10 (0.1)
4 (0.2)
14 (0.3)
3 (0.2)
Intoxication (n/%)
4 (0.0)
0 (0.0)
5 (0.1)
1 (0.1)
2013
Mean level (ng/mL)
24.1 ± 8.0
24.8 ± 7.6
<0.001
22.6 ± 8.8
24.1 ± 8.1
<0.001
Deficient (n/%)
4,444 (30.4)
1,016 (25.8)
4,801 (83.6)
1,625 (78.8)
Sufficient (n/%)
10,151 (69.4)
2,917 (74.0)
921 (16.0)
431 (20.9)
≥60 to 100 (n/%)
22 (0.2)
10 (0.3)
13 (0.2)
6 (0.3)
Intoxication (n/%)
8 (0.1)
0 (0.0)
7 (0.1)
1 (0.0)
2014
Mean level (ng/mL)
28.4 ± 9.2
29.4 ± 8.7
<0.001
28.1 ± 9.6
29.0 ± 9.8
<0.001
Deficient (n/%)
2,424 (15.2)
600 (10.9)
3,184 (62.6)
1,224 (58.4)
Sufficient (n/%)
13,432 (84.1)
4,877 (88.5)
1,859 (36.6)
853 (40.7)
≥60 to 100 (n/%)
107 (0.7)
32 (0.6)
35 (0.7)
17 (0.8)
Intoxication (n/%)
13 (0.1)
4 (0.1)
6 (0.1)
3 (0.1)
2015
Mean level (ng/mL)
28.6 ± 9.2
30.1 ± 9.3
<0.001
28.1 ± 9.8
29.9 ± 10.4
<0.001
Deficient (n/%)
2,452 (14.6)
607 (9.4)
2,929 (61.3)
1,260 (55.4)
Sufficient (n/%)
14,277 (84.7)
5,809 (89.8)
1,812 (37.9)
988 (43.4)
≥60 to 100 (n/%)
100 (0.6)
45 (0.7)
28 (0.6)
25 (1.1)
Intoxication (n/%)
18 (0.1)
11 (0.2)
8 (0.2)
3 (0.1)
2016
Mean level (ng/mL)
28.6 ± 9.7
30.1 ± 10.1
<0.001
28.1 ± 10.0
30.1 ± 10.1
<0.001
Deficient (n/%)
2,241 (15.0)
686 (11.2)
2,664 (63.4)
1,143 (55.8)
Sufficient (n/%)
12,605 (84.2)
5,382 (87.7)
1,499 (35.7)
882 (43.0)
≥60 to 100 (n/%)
103 (0.7)
60 (1.0)
36 (0.9)
23 (1.1)
Intoxication (n/%)
21 (0.1)
12 (0.2)
2 (0.0)
2 (0.1)
2017
Mean level (ng/mL)
29.0 ± 10.4
31.0 ± 8.3
<0.001
29.0 ± 9.7
30.6 ± 8.8
<0.001
Deficient (n/%)
1,306 (9.6)
334 (5.6)
2,115 (55.7)
806 (44.2)
Sufficient (n/%)
12,180 (89.9)
5,617 (93.7)
1,665 (43.8)
1,006 (55.2)
≥60 to 100 (n/%)
47 (0.3)
32 (0.5)
15 (0.4)
10 (0.5)
Intoxication (n/%)
16 (0.1)
9 (0.2)
5 (0.1)
2 (0.1)
2018
Mean level (ng/mL)
27.9 ± 11.1
30.2 ± 11.0
<0.001
30.1 ± 72.2
29.5 ± 8.9
<0.001
Deficient (n/%)
1,615 (13.6)
430 (7.8)
1,962 (61.0)
991 (56.4)
Sufficient (n/%)
10,245 (86.0)
5,044 (91.4)
1,217 (37.8)
758 (43.1)
≥60 to 100 (n/%)
40 (0.3)
40 (0.7)
30 (0.9)
8 (0.5)
Intoxication (n/%)
14 (0.1)
5 (0.1)
8 (0.2)
1 (0.1)
Total
Mean level (ng/mL)
27.2 ± 9.7
29.2 ± 9.6
<0.001
25.9 ± 23.2
28.0 ± 9.9
<0.001
Deficient (n/%)
19,851 (19.1)
4,632 (12.5)
27,112 (70.9)
9,109 (62.0)
Sufficient (n/%)
83,401 (80.3)
32,074 (86.7)
10,837 (28.4)
5,471 (37.2)
≥60 to 100 (n/%)
472 (0.5)
229 (0.6)
214 (0.6)
101 (0.7)
Intoxication (n/%)
103 (0.1)
43 (0.1)
62 (0.2)
14 (0.1)
M