We report a case of drug-induced lupus (DIL) on a Chinese woman caused by methimazole (MMI). This report discusses DIL associated with MMI and briefly reviewed the literature concerning to anti-thyroid DIL.
We report a case of drug-induced lupus (DIL) on a Chinese woman caused by methimazole (MMI). This report discusses DIL associated with MMI and briefly reviewed the literature concerning to anti-thyroid DIL.
| February 20, 2012 In the First Affiliated Hospital of Cheng Du medical college | February 25, 2012 In the Chinese people’s Liberation Army General Hospital of Chengdu Military Region | April 17, 2012 In the First Affiliated Hospital of Cheng Du medical college | May 27, 2012 In West China Hospital, Sichuan University | |
|---|---|---|---|---|
| ESR | 50 mm/h | 55 mm/h | 70 mm/h | 10 mm/h |
| ANA (< 1:20) | 1:320 | 1:320 | — | — |
| Anti-Sm | — | + | — | — |
| Anti-ds-DNA | — | — | — | — |
| ANCA | — | — | — | — |
| C3, C4 levels | Normal | Normal | Normal | Normal |
| Albuminuria | Normal | Normal | Normal | Normal |
| Blood routine | WBC 13.55 × 109/L, N: 80.3% | Normal | WBC 29.84 × 109/L, N: 85.4% | Normal |
| Temperature | 38.5°C | 37-39°C | 39.2°C | Normal |
| Antithyroid drugs | MMI, 20 mg, qd | radioactive Iodine-131 | PTU, 200 mg, tid | — |
| Prednisone | — | 60 mg, qd | 60 mg, qd | — |
| Arthralgia | + | + | — | — |
| DIL | SLE | |
|---|---|---|
| ESR | < 50% | 80% |
| Anemia | < 30% | 80% |
| Leukopenia | < 10% | 65% |
| Thrombocytopenia | < 10% | 30% |
| Albuminuria | < 30% | 90% |
| Hypocomplementemia | < 10% | 80% |
| Rheumatoid factor | 30% | 50% |
| ANA | 90% | 95% |
| Anti-Smith antibody | 0 | 50% |
| Anti-dsDNA antibody | 0 | 40% |