Chang, 202355. Chang LC, Chang CY, Chen CY, Tseng CH, Chen PJ, Shun CT, et al. Cold Versus Hot Snare Polypectomy for Small Colorectal Polyps. Ann Intern Med. 2023;176:311-9. |
Multicentric RCT |
CSP X HSP |
4-10 mm |
4270 |
10040 |
All polyp morphologies |
Negative margin of the resected specimen |
Complete resection rate, en bloc resection, delayed bleeding, polypectomy time, total procedure time |
Rex DK, 20222424. Rex DK, Anderson JC, Pohl H, Lahr RE, Judd S, Antaki F, et al. Cold versus hot snare resection with or without submucosal injection of 6- to 15-mm colorectal polyps: a randomized controlled trial. Gastrointest Endosc . 2022;96:330-8. |
Multicentric RCT |
CSP X C-EMR x HSP x EMR |
6-15mm |
235 |
286 |
Nonpedunculated polyps |
Negative margin biopsies |
Complete resection rate |
Koyanagi R, 20223030. Koyanagi R, Honda M, Kawamura H, Hamada K, Horikawa Y, Shiwa Y, et al. Clinical Benefit of Polypectomy With Cutting Current for Colorectal Polyps: A Randomized Controlled Trial. Anticancer Res. 2022;42:3613-9. |
Unicentric RCT |
CSP x HSP |
6-10mm |
49 |
61 |
Nonpedunculated polyps |
Negative margin of the resected specimen |
Complete Resection rate, immediate bleeding, delayed bleeding, |
Pedersen IB, 20222525. Pedersen IB, Rawa-Golebiewska A, Calderwood AH, Brix LD, Grode LB, Botteri E, et al. Complete polyp resection with cold snare versus hot snare polypectomy for polyps of 4-9 mm: a randomized controlled trial. Endoscopy. 2022;54:961-9. |
Multicentric RCT |
CSP x HSP |
4-9mm |
425 |
601 |
Nonpedunculated polyps |
Negative margin biopsies |
Complete resection rate, en bloc resection, immediate bleeding, delayed bleeding |
Fatima H, 20222020. Fatima H, Rex DK, Imperiale T. A Pilot Randomized Trial of Polypectomy Techniques for 4 to 6 mm Colonic Polyps. J Clin Gastroenterol. 2022;56:426-32. |
Multicentric RCT |
CF x CSP x HSP |
4-6mm |
260 |
318 |
Adenomatous Polyps |
Negative margin of the resected specimen |
Immediate bleeding, delayed bleeding |
Varytimiadis L, 20213434. Varytimiadis L, Viazis N, Gkolfakis P, Tribonias G, Tziatzios G, Kyriakopoulos G, et al. Cold snare polypectomy vs. hot snare polypectomy vs. argon plasma coagulation for small (5-9mm) left-sided colorectal polyps: a prospective randomized trial. Eur J Gastroenterol Hepatol . 2021;33(1S Suppl 1):e909-15. |
Unicentric RCT |
CSP x HSP x APC |
5-9mm |
112 |
121 |
All polyps in left colon |
Negative margin of the resected specimen |
Complete resection rate, immediate bleeding |
Ito T, 20213535. Ito T, Takahashi K, Tanabe H, Sato K, Goto M, Sato T, et al. Safety and efficacy of cold snare polypectomy for small colorectal polyps: A prospective randomized control trial and one-year follow-up study. Medicine. 2021 Jun 11;100(23):e26296. |
Unicentric RCT |
CSP x HSP |
6-10mm |
332 |
332 |
Nonpedunculated polyps |
Negative margin of the resected specimen |
En Bloc resection, immediate bleeding, delayed bleeding, polypectomy time, total procedure time |
De Benito Sanz M, 20203636. de Benito Sanz M, Hernández L, Garcia Martinez MI, Diez-Redondo P, Joao Matias D, Gonzalez-Santiago JM, et al. Efficacy and safety of cold versus hot snare polypectomy for small (5-9 mm) colorectal polyps: a multicenter randomized controlled trial. Endoscopy. 2022;54:35-44. |
Multicentric RCT |
CSP x HSP |
5-9mm |
488 |
791 |
All polyp morphologies |
Negative margin biopsies |
Complete resection rate, en bloc resection, immediate bleeding, delayed bleeding, |
Li D, 20201111. Li D, Wang W, Xie J, Liu G, Wang R, Jiang C, et al. Efficacy and safety of three different endoscopic methods in treatment of 6-20 mm colorectal polyps. Scand J Gastroenterol. 2020;55:362-70. |
Unicentric RCT |
CSP x C-EMR x EMR |
6-20mm |
404 |
763 |
Any polyp type, except hyperplastic and inflammatory |
Negative margin biopsies |
Complete resection rate |
Takeuchi Y, 20191313. Takeuchi Y, Mabe K, Shimodate Y, Yoshii S, Yamada S, Iwatate M, et al. Continuous Anticoagulation and Cold Snare Polypectomy Versus Heparin Bridging and Hot Snare Polypectomy in Patients on Anticoagulants With Subcentimeter Polyps: A Randomized Controlled Trial. Ann Intern Med . 2019;171(4):229-37. |
Multicentric RCT |
CSP (+CA) x HSP (+HB) |
≤10 mm |
168 |
611 |
Nonpedunculated polyps |
NA |
Polypectomy time |
Aizawa M, 20191616. Aizawa M, Utano K, Tsunoda T, Ichii O, Kato T, Miyakura Y, et al. Delayed hemorrhage after cold and hot snare resection of colorectal polyps: a multicenter randomized trial (interim analysis). Endosc Int Open. 2019;7:E1123-9. |
Multicentric RCT |
CSP X HSP |
≤10mm |
273 |
727 |
All polyp morphologies |
NA |
Delayed Bleeding |
Zhang Q, 20182121. Zhang Q, Gao P, Han B, Xu J, Shen Y. Polypectomy for complete endoscopic resection of small colorectal polyps. Gastrointest Endosc. 2018;87:733-40. |
Unicentric RCT |
CSP x EMR |
6-9mm |
358 |
525 |
Nonpedunculated polyps |
Negative margin biopsies |
Complete resection rate, en bloc resection, immediate bleeding, delayed bleeding, polypectomy time |
Suzuki S, 20181919. Suzuki S, Gotoda T, Kusano C, Ikehara H, Sugita A, Yamauchi M, et al. Width and depth of resection for small colorectal polyps: hot versus cold snare polypectomy. Gastrointest Endosc. 2018;87:1095-103. |
Unicentric RCT |
CSP x HSP |
≤10 mm |
52 |
52 |
Nonpedunculated polyps |
Negative margin of the resected specimen |
Complete resection rate, en bloc resection, immediate bleeding, delayed bleeding |
Kawamura T, 20172929. Kawamura T, Takeuchi Y, Asai S, Yokota I, Akamine E, Kato M, et al. A comparison of the resection rate for cold and hot snare polypectomy for 4-9 mm colorectal polyps: a multicentre randomised controlled trial (CRESCENT study). Gut. 2018;67:1950-7. |
Multicentric RCT |
CSP x HSP (+ EMR) |
4-9 mm |
538 |
687 |
Nonpedunculated polyps |
Negative margin biopsies |
Complete resection rate, en bloc resection, immediate bleeding, delayed bleeding, polypectomy time |
Papastergiou V, 20173737. Papastergiou V, Paraskeva KD, Fragaki M, Dimas I, Vardas E, Theodoropoulou A, et al. Cold versus hot endoscopic mucosal resection for nonpedunculated colorectal polyps sized 6-10 mm: a randomized trial. Endoscopy. 2018;50:403-11. |
Multicentric RCT |
C-EMR x EMR. |
6-10 mm |
155 |
164 |
Nonpedunculated polyps |
Negative margin biopsies |
Complete resection rate, immediate bleeding, delayed bleeding |
Horiuchi A, 201577. Horiuchi A, Nakayama Y, Kajiyama M, Tanaka N, Sano K, Graham DY. Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy. Gastrointest Endosc. 2014;79:417-23. |
Unicentric RCT |
CSP (+CA) x HSP(+ CA) |
≤10 mm |
70 |
159 |
Any polyp time, except hyperplastic |
Negative margin of the resected specimen |
Complete resection rate, total procedure time |
Gomez V, 20143838. Gómez V, Badillo RJ, Crook JE, Krishna M, Diehl NN, Wallace MB. Diminutive colorectal polyp resection comparing hot and cold snare and cold biopsy forceps polypectomy. Results of a pilot randomized, single-center study (with videos). Endosc Int Open . 2015;3:E76-80. |
Unicentric RCT |
CSP x HSP x CFP |
<6 mm |
37 |
62 |
Adenomatous and hyperplasic polyps |
Negative margin biopsies or C-EMR of the resection site |
Complete resection rate, immediate bleeding, delayed bleeding |
Paspatis G, 20113939. Paspatis GA, Tribonias G, Konstantinidis K, Theodoropoulou A, Vardas E, Voudoukis E, et al. A prospective randomized comparison of cold vs hot snare polypectomy in the occurrence of postpolypectomy bleeding in small colonic polyps. Colorectal Dis. 2011;13:e345-8. |
Unicentric RCT |
CSP x HSP |
3-8 mm |
414 |
1083 |
All polyp morphologies |
Negative margin of the resected specimen |
Delayed bleeding, total procedure time |
Ichise Y, 20114040. Ichise Y, Horiuchi A, Nakayama Y, Tanaka N. Prospective randomized comparison of cold snare polypectomy and conventional polypectomy for small colorectal polyps. Digestion. 2011;84:78-81. |
Unicentric RCT |
CSP x HSP |
≤8 mm |
80 |
205 |
Any polyp type except hyperplastic in rectum or sigmoid |
Negative margin of resected specimen |
Complete resection rate, immediate bleeding, delayed bleeding, total procedure time |