Guariso G, et al. 2010.1919. Guariso G, Meneghel A, Pozza LVD, Romano C, Dall’Oglio L, Lombardi G, et al. Indications to Upper Gastrointestinal Endoscopy in Children With Dyspepsia. J Pediatr Gastroenterol Nutr . 2010;50:493-9. |
Observational retrospective study |
2304 |
Check if endoscopic indications for children with dyspepsia were adequate |
Endoscopy is appropriately indicated only in cases of family history of peptic ulcer and/or H. pylori, when it interferes with daily activities, when age is more than 10 years, and the longer the duration and the more severe the symptoms. |
Canan O, et al. 2011.2222. Canan O, Ozcay F, Ozbay-Hosnut F, Yazici C, Bilezikci B. Value of the Likert Dyspepsia Scale in Differentiation of Functional and Organic Dyspepsia in Children. J Pediatr Gastroenterol Nutr . 2011;52:392-8. |
Prospective experimental study |
161 10-17 years |
Define a symptomatic score that indicates organic dyspepsia, before endoscopy. |
It was not possible to determine a cutoff value in the score that differentiated organic from functional dyspepsia. |
Tam YH, et al. 2011.2020. Tam YH, Chan KW, To KF, Cheung ST, Mou JWC, Pang KKY, et al. Impact of pediatric Rome III criteria of functional dyspepsia on the diagnostic yield of upper endoscopy and predictors for a positive endoscopic finding. J Pediatr Gastroenterol Nutr . 2011;52:387-91. |
Prospective experimental study |
80 7-15 years |
To evaluate the efficiency of the Rome III criteria as a guideline to differentiate organic from functional dyspepsia, and identify predictors for positive endoscopic findings. |
The Rome III criteria are effective in screening for functional dyspepsia in children and to differentiate from those with organic dyspepsia. |
Carvalho MA, et al. 2012.2424. Carvalho MA, Machado NC, Ortolan EVP, Rodrigues MAM. Upper Gastrointestinal Histopathological Findings in Children and Adolescents With Nonulcer Dyspepsia With Helicobacter pylori Infection. J Pediatr Gastroenterol Nutr . 2012;55:523-9. |
Cross-sectional case control study |
185 4-17 years |
To investigate the histopathology of lesions in the gastric mucosa, associated with infection by H. pylori in patients with dyspepsia without peptic ulcer. |
There is a higher prevalence of H. pylori infection in participants with dyspepsia who had significant inflammation in the mucosa. |
Ganesh M, et al. 2014.2121. Ganesh M, Nurko S. Functional Dyspepsia in Children . Pediatric Annals. 2014;43:e101-5. |
Review |
- |
To review the characteristics of functional dyspepsia, endoscopic findings, diagnostic method, types of treatment. |
Functional dyspepsia must be diagnosed by the Rome III criteria. |
Hyams JS, et al. 2016.55. Hyams JS, Di Lorenzo C, Saps M, Shulman RJ, Staiano A, van Tilburg M. Childhood Functional Gastrointestinal Disorders: Child/Adolescent. Gastroenterology. 2016;150:1456-68.e2. |
Review |
- |
To review the changes between Rome III and Rome IV criteria, regarding the definitions of disorders and their respective treatments. |
The Roma IV committee does not believe that endoscopy is necessary to make a diagnosis of functional dyspepsia. |
Koppen IJ, et al. 2017.1818. Koppen IJN, Nurko S, Saps M, Di Lorenzo C, Benninga MA. The pediatric Rome IV criteria: what’s new? Expert Rev Gastroenterol Hepatol . 2017;11:193-201. |
Review |
- |
To report the news contained in the Rome IV criteria in comparison to the previous ones. |
The Rome IV criteria are well formulated and help a lot in the diagnosis of functional gastrointestinal disorders in children. |
Wauters L, et al. 2017.2626. Wauters L, Nightingale S, Talley NJ, Sulaiman B, Walker MM. Functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort. Aliment Pharmacol Ther. 2017;45:1358-64. |
Cohort retrospective study |
72 4-18 years |
Association between dyspeptic symptoms and duodenal eosinophilia in endoscopy. |
Functional dyspepsia is strongly related to duodenal eosinophilia. |
Saps M, et al. 2019.2929. Saps M, Moreno-Gomez JE, Ramírez-Hernández C, Rosen JM, Velasco-Benitez CA. A nationwide study on the prevalence of functional gastrointestinal disorders in school-children. Bol Med Hosp Infant Mex. 2017;74:407-12. |
Cross-sectional |
4394 8-18 years |
To determine the prevalence of functional gastrointestinal disorders in school children in Colombia and its associated factors. |
These disorders are more common in children in private schools than in public schools and are associated with stress. |
Rajindrajith S, et a.l 2018.77. Rajindrajith S, Zeevenhooven J, Devanarayana NM, Perera BJC, Benninga MA. Functional abdominal pain disorders in children. Expert Rev Gastroenterol Hepatol. 2018;12:369-90. |
Review |
- |
Study on functional abdominal pain disorders. |
Endoscopy should be considered when alarm symptoms are present. |
Chumpitazi BP, et al. 2018.3030. Chumpitazi BP, Robayo-Torres CC, Tsai CM, Opekun AR, Baker SS, Nichols BL, et al. Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia. J Pediatr Gastroenterol Nutr . 2018;66:S52-5. |
Retrospective and prospective |
129 4-18 years |
To determine the frequency, demographics and clinical characteristics associated with disaccharidase deficiency in children with dyspepsia. |
Half of children with functional dyspepsia had disaccharidase deficiency. There may be a race/ethnicity relationship. |
Friesen C, et al. 2018.3131. Friesen C, Singh M, Singh V, Schurman JV. An observational study of headaches in children and adolescents with functional abdominal pain. Medicine. 2018;97:e11395. |
Cross-sectional retrospective |
235 8-17 years |
To evaluate the relationship between headaches and functional dyspepsia and headaches with mucosal mast cells and eosinophils. |
Headaches are related to the presence of functional dyspepsia and to increased duodenal mast cell density and variety of somatic symptoms. |
Saps M, et al. 2018.2828. Saps M, Velasco-Benitez CA, Langshaw AH, Ramírez-Hernández CR. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents: Comparison Between Rome III and Rome IV Criteria. J Pediatr . 2018;199:212-6. |
Observational |
3767 8-18 years |
Compare the prevalence of functional gastrointestinal disorders in children using the Rome III criteria and then, using the Rome IV criteria. |
Using the Rome IV criteria resulted in a decrease in the prevalence of these disorders, and the new diagnoses of these criteria were present in a small percentage of children. |
Trivić I, et al. 2018.2323. Trivić I, Hojsak I. Initial Diagnosis of Functional Gastrointestinal Disorders in Children Increases a Chance for Resolution of Symptoms. J Pediatr Gastroenterol Nutr . 2018;21:264. |
Observational |
294 1-18 years |
Detect the symptoms of patients with functional gastrointestinal disorders, the characteristics and results of the diagnostic investigation. |
Early diagnosis increases the chance of symptom resolution, and these disorders affect quality of life. |
Adeniyi OF, et al. 2019.2525. Adeniyi OF, Odeghe EA, Lawal MA, Olowu AO, Ademuyiwa A. Recurrent abdominal pain and upper gastrointestinal endoscopy findings in children and adolescents presenting at the Lagos University Teaching Hospital. Tokuhara D, editor. Plos One. 2019;14:e0216394. |
Prospective descriptive |
113 Children under 19 years |
Describe endoscopic findings in children with recurrent abdominal pain. |
Upper gastrointestinal endoscopy is valuable in investigating recurrent abdominal pain in children, as it offers an accurate diagnosis of the causes. |
Toporovski MS, et al. 1998.2727. Toporovski MS, Neufeld CB, Chiara AMM, Françoso LA, Beznos GW, Coates V. Peptic disease: comparative study between children and adolescents. J Pediatr. 1998;74:233-8. |
|
106 4-16 years |
Compare clinical, endoscopic and colonization data of H. pylori in children and teenagers with peptic disease. |
Prevalence of peptic disease in females. All with digestive bleeding associated with ulcerative lesions were colonized by H. pylori. |