EFFECT OF THE CONSUMPTION OF A CHEESE ENRICHED WITH PROBIOTIC ORGANISMS (BIFIDOBACTERIUM LACTIS BI-07) IN IMPROVING SYMPTOMS OF CONSTIPATION

FAVRETTO, Diane Cássia; PONTIN, Bruna; MOREIRA, Thaís Rodrigues

doi:10.1590/S0004-28032013000200035

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Original Articles • Arq. Gastroenterol. 50 (3) • July-Sept 2013 • https://doi.org/10.1590/S0004-28032013000200035 copy

EFFECT OF THE CONSUMPTION OF A CHEESE ENRICHED WITH PROBIOTIC ORGANISMS (BIFIDOBACTERIUM LACTIS BI-07) IN IMPROVING SYMPTOMS OF CONSTIPATION

Efeito da ingestão de um queijo acrescido de microrganismos probióticos (bifidobacterium lactis bi-07) na melhora de sintomas de constipação

Authorship SCIMAGO INSTITUTIONS RANKINGS

Context

Constipation is a very common symptom in the general population. One way of non-pharmacological treatment of constipation is through the addition of probiotics to food.

Obectives

The aim of this study was to evaluate de effect of the consumption of a fresh cheese, enriched with Bifidobacterium lactis Bi-07 on the symptoms of constipated women.

Methods

A randomized controlled trial, carried out in the Basic Health Units of Guaporé's City – RS/Brazil, between january and may 2012, with 30 constipated women. The patients were randomized into two groups whom received, for 30 days, 30 g of fresh cheese enriched with Bifidobacterium lactis Bi-07 (n = 15) or regular fresh cheese (n = 15). Constipation symptoms were evaluated according to ROMA III Consensus, before and after the nutritional intervention. Also, data of clinical and anthropometric characteristics of the individuals were collected. Accepted level of significance 5% (P≤0,05).

Results

The medium age of the studied population was 37,5±14,4 years in the intervention group and 40,8±12,8 years in the control group. After 30 days we observed that the ingestion of fresh cheese enriched with Bifidobacterium lactis Bi-07 promoted benefic effects on the symptoms of strength to evacuate.

Conclusion

The consumption of 30g/day of a fresh cheese enriched with Bifidobacterium lactis Bi-07 has beneficial effects on constipation symptoms.

Constipation; Probiotics; Bifidobacterium ; Cheese

Parameter	Intervention	Control	P
Parameter	(n = 15)	(n = 15)	P
Age (years)	37.5 ± 14.4	40.8 ± 12.8	0.509^* * Student's t test - data presented as mean and standard deviation;
Weight (kg)	70.8 ± 12.3	67.6 ± 18.4	0.579^* * Student's t test - data presented as mean and standard deviation;
Height (m)	1.62 ± 0.05	1.58 ± 0.06	0.113^* * Student's t test - data presented as mean and standard deviation;
BMI (kg/m²)	27.0 ± 4.4	27.0 ± 7.4	0.986^* * Student's t test - data presented as mean and standard deviation;
Physical activity			1.000#
Yes	8 (53.3)	7 (46.7)
No	7 (46.7)	8 (53.3)
Use of probiotic			0.651#
Yes	4 (26.7)	2 (13.3)
No	11 (73.3)	13 (86.7)
Type of probiotic			0.505#
None	11 (73.3)	13 (86.7)
B. animalis	3 (20.0)	2 (13.3)
L. acidophillus + B. animalis	1 (6.7)	0 (0.0)
Water ingestion			0.557#
Up to 1 liter/day	4 (26.7)	5 (33.3)
From 1 to 2 liters/day	8 (53.3)	9 (60.0)
Above 2 liters/day	3 (20.0)	1 (6.7)

Nutrients	Intervention	Control	P
Nutrients	(n = 15)	(n = 15)	P
Calories consumption (Kcal/day)	1682 ± 191	1829 ± 364	0,176^* * Student's t test;
Energy need/day (% by HB)	93,4 ± 12,1	106 ± 21,7	0,053^* * Student's t test;
Energy need/day (% by FAO/OMS)	82,0 ± 26,2	94,8 ± 21,3	0,151^* * Student's t test;
Carbohydrates g/day	238 ± 37,3	272 ± 73,1	0,123^* * Student's t test;
Carbohydrates %/day	57,2 ± 7,2	59,2 ± 9,0	0,509^* * Student's t test;
Proteins g/day	73,9 ± 18,2	74,0 ± 24,1	0,984^* * Student's t test;
Proteins %/day	18,2 ± 3,7	16,4 ± 5,0	0,282^* * Student's t test;
Lipids g/day	46,3 ± 16,4	48,5 ± 17,8	0,733^* * Student's t test;
Lipids %/day	24,6 ± 7,8	24,4 ± 8,2	0,938^* * Student's t test;
Fibers g/day	19,0 (11,2 – 35,5)	28,6 (12,6 – 34,5)	0,512^# # Mann-Whitney test; HB: Harris & Benedict formula (1919); FAO/OMS: Formula Food and Agriculture Organization of the United Nations and Food/ World Health Organization (1985)
Soluble fibers g/day	1,55 (0,13 – 3,27)	1,39 (0,90 – 2,15)	0,713^# # Mann-Whitney test; HB: Harris & Benedict formula (1919); FAO/OMS: Formula Food and Agriculture Organization of the United Nations and Food/ World Health Organization (1985)
Insoluble fibers g/day	1,64 (0,08 – 3,28)	2,62 (2,01 – 3,67)	0,345^# # Mann-Whitney test; HB: Harris & Benedict formula (1919); FAO/OMS: Formula Food and Agriculture Organization of the United Nations and Food/ World Health Organization (1985)
Total cholesterol mg/day	137 (99,2 – 191)	235 (97,1 – 291)	0,539^# # Mann-Whitney test; HB: Harris & Benedict formula (1919); FAO/OMS: Formula Food and Agriculture Organization of the United Nations and Food/ World Health Organization (1985)
Calcium mg/day	689 (481 – 968)	522 (387 – 688)	0,174^# # Mann-Whitney test; HB: Harris & Benedict formula (1919); FAO/OMS: Formula Food and Agriculture Organization of the United Nations and Food/ World Health Organization (1985)
Iron mg/day	11,1 (5,3 – 14,8)	13,2 (8,3 – 14,6)	0,412^# # Mann-Whitney test; HB: Harris & Benedict formula (1919); FAO/OMS: Formula Food and Agriculture Organization of the United Nations and Food/ World Health Organization (1985)

Frequency	Intervention		Control		Between groups – Pre- x post- difference
Frequency	P25–P75	P	P25–P75	P	Intervention P25–P75	Control P25–P75	P
Effort to evacuate					-2 (-3 to -2)	-1 (-3 to 0)	NS
Pre	3 (2 – 3)	0.002	3 (2 – 4)	0.030
Post	0 (0 – 1)		1 (1 – 3)
Hard or lumpy stools		0.001		0.028	-2 (-3 to -1)	-2 (-3 to 0)	NS
Pre	3 (2 – 3)		3 (3 – 3)
Post	1 (0 – 1)		1 (0 – 3)
Sensation of incomplete evacuation		0.006		NS	-2 (-3 to -1)	-1 (-3 to 2)	NS
Pre	2 (1 – 3)		2 (1 – 4)
Post	0 (0 – 1)		2 (1 – 4)
Sensation of anorectal obstruction or blockage		0.001		NS	-2 (-3 to -1)	-1 (-2 to 1)	0.041
Pre	2 (1 – 3)		2 (1 – 2)
Post	0 (0 – 0)		1 (0 – 3)
Digital or manual maneuvers to ease the evacuation		NS		NS	0 (0 to 0)	0 (-1 to 0)	NS
Pre	0 (0 – 0)		0 (0 – 1)
Post	0 (0 – 0)		0 (0 – 1)
Frequency of bowel movements per week		0.001		0.028	4.5 (3 to 6)	1 (-1 to 3)	0.002
Pre	1.5 (1 – 2)		3 (1 – 4)
Post	6 (5 – 7)		4 (2 – 7)
Constipation – n(%)		<0.001		<0.001	-93.3%	-47.7%	0.014
Pre	15 (100)		15 (100)
Post	1 (6.7)		8 (53.3)

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[1] Correspondence: Thaís Rodrigues Moreira. Avenida Avelino Tallini, 171. Sala 216, prédio 11. Bairro Universitário - 95900-000 - Lajeado, RS, Brasil. E-mail: th_rodrigues@ibest.com.br

Effort to evacuate
(A) In the past six months, how often have you had to force or make an effort to defecate?	(0) Never or rarely
	(1) Sometimes
	(2) Often
	(3) Most of the times
	(4) Always
Hard or lumpy stools
(B) In the past six months, how often did you have hard stools, hardened or as if they were marbles?	(0) Never or rarely
	(1) Sometimes
	(2) Often
	(3) Most of the times
	(4) Always
Sensation of incomplete evacuation
(C) In the past six months, how often have you had the sensation of incomplete evacuation, i.e. even after evacuation, the need remained?	(0) Never or rarely
	(1) Sometimes
	(2) Often
	(3) Most of the times
	(4) Always
Sensation of anorectal blockage or obstruction
(D) In the past six months, how often have you felt that the stool fail to pass, that it is locked or trapped in the anus?	(0) Never or rarely
	(1) Sometimes
	(2) Often
	(3) Most of the times
	(4) Always
Manual maneuvers to facilitate defecation
(E) In the past six months, how often have you had to use your finger to help in the passage of stool?	(0) Never or rarely
	(1) Sometimes
	(2) Often
	(3) Most of the times
	(4) Always
Number of defecations per week (F) How many times per week do you usually evacuate?	_____times/week