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Neuroendoscopic treatment of quadrigeminal arachnoid cyst in a two-year-old child

Tratamento neuroendoscópico de cisto aracnóide quadrigeminal em criança de dois anos de idade

CLINICAL/SCIENTIFIC NOTE

Neuroendoscopic treatment of quadrigeminal arachnoid cyst in a two-year-old child

Tratamento neuroendoscópico de cisto aracnóide quadrigeminal em criança de dois anos de idade

João Paulo C. de AlmeidaI; Saul QuininoII; Igor Vilela FaquiniII; Danilo Otávio de A. SilvaII; Lucas Alverne F. de AlbuquerqueI; Jean Carlos de Araújo MendesII; Hildo Azevedo-FilhoIII

IMedical School, Federal University of Ceara, Fortaleza CE, Brazil - Department of Neurosurgery, Hospital da Restauração, Recife PE, Brazil

IIDepartment of Neurosurgery, Hospital da Restauração, Recife PE, Brazil - Department of Neurosurgery, Hospital da Restauração, Recife PE, Brazil

IIIProfessor and Chairman, Department of Neurosurgery, Hospital da Restauração, Recife PE, Brazil - Department of Neurosurgery, Hospital da Restauração, Recife PE, Brazil

Arachnoid cysts of the posterior fossa represent a rare group of central nervous system lesions. Quadrigeminal cistern cysts, specifically, are unusual lesions, with only 79 cases described in the English literature1-8. Classical treatment of such lesions consists of craniectomy and fenestration of the lesion or cystoperitoneal shunting. Neuroendoscopy represents a new effective minimally invasive approach for such lesions.

We report the case of a two year old boy who presented a quadrigeminal cyst arachnoid cyst which was successfully treated by neuroendoscopy in our department.

CASE

A two-year-old boy, presented to our department with one month history of daily headaches, vomiting and gait instability. There was no report of recent associated infections, previous history of any classical childhood viral infection or alterations of psychomotor development. The exam at admission revealed a hypoactive child, obvious macrocrania and gait instability associated with lower limbs hypertonia. There was no papilloedema. There were no cranial nerves or sensitive alterations. Analysis of the cephalic perimeter growth curve showed mild upward deviation since the initial months of life. Computed tomography (CT) scan demonstrated supratentorial hydrocephalus associated with a cystic lesion in the posterior fossa. Magnetic resonance image (MRI) demonstarted enlargement of the supratentorial ventricular system secondary to a large quadrigeminal cistern arachnoid cyst compressing the brainstem, cerebellum, aqueduct of Sylvius and fourth ventricle (Fig 1). A ventriculo-peritoneal shunt was inserted at this time, with regression of the symptoms.


Seven months later, the patient returned to our department with history of new episodes of headache and vomiting. A new MRI revealed persistence of the arachnoid cyst. It was decided to perform endoscopic fenestration of the cyst and third ventriculostomy for treatment of the hydrocephalus.

Informed consent was obtained from the family and the patient underwent the surgical procedure. A paramedian incision was performed overlying the right coronal suture, 2.5 cm off the midline. Then a 14-mm burr hole was created and the dura-mater opened. After navigating through the right lateral ventricle and third ventricle, the arachnoid cyst was reached and cysto-ventricle shunting was realized. This was followed by a third ventriculostomy. There were no complications during the surgery. The patient presented no symptoms at time of discharge (Fig 2A).


At one year follow-up, the patient was asymptomatic. Neurological examination was unremarkable (Fig 2B).

DISCUSSION

Paracollicular arachnoid cyst, cysts posterior to the third ventricle, tentorial notch arachnoid cyst, cyst of cisterna ambiens, paramesencephalic cysts and parapineal cysts are all synonyms for quadrigeminal cistern arachnoid cyst1. Quadrigeminal cistern is a rare location for an arachnoid cyst: only 53 cases were reported in the literature until 19992. Review of articles published in the last years demonstrates that another 26 cases have been reported1,3-8.

Typical clinical presentation of a quadrigeminal cistern cyst includes headache, vomiting, visual complaints, and gait ataxia9. These symptoms are primarily caused by pressure against the tectal plate, which can also compress the aqueduct of Sylvius and lead to hydrocephalus10. Cerebellar and brainstem compression occasionally occur, as well10.

Quadrigeminal cysts appear as midline, supracerebellar, infratentorial cysts that abuts the quadrigeminal cistern on CT and MRI imaging with no enhancement and presenting the same attenuation values as the cerebrospinal fluid (CSF)11. The enlarging cyst projects downwards and backward to lie over the superior surface of the cerebellum. The aqueduct and fourth ventricle are displaced downwards and forwards and tectal compression occurs2. The third ventricle is distorted and anteriorly displaced. The aqueduct is stretched causing obstructive hydrocephalus.

Traditionally, arachnoid cysts of the quadrigeminal cistern have been treated in two ways, via craniotomy and fenestration and via cystoperitoneal shunting12. Although open surgery allows arachnoid cysts to be exposed under direct vision and completely resected, it inevitably requires craniotomy. As many as one-third of those with arachnoid cysts and concomitant hydrocephalus who undergo open surgery require additional shunt placement for recurrent hydrocephalus13. Shunt placement without fenestration of the cyst is an alternative treatment, but occlusion, disconnection, or infection of the shunt system remains a potential threat to patients undergoing these procedures3.

In a review of the literature, Ruge et al. demonstrated the outcomes and complications of 48 quadrigeminal cistern arachnoid cysts treated by traditional techniques9. Two patients treated with shunt died and three remained unchanged. Out of 23 patients treated with craniotomy and fenestration alone, one died and three remained with some degree of impairment (the outcome is unknown in 10 patients of this group); two of five patients who were treated by craniotomy plus fenestration and shunt continued to present some impairment after the procedures.

With the extent of the indications to ventricular endoscopy, the neuroendoscopic approach to quadrigeminal cysts has gained an increasing rate of acceptance. Many authors have shown that limited openings of the cyst walls might be sufficient to reestablish a functional CSF circulation and cyst size reduction. In this context, when compared to open surgery, neuroendoscopy has the main advantage to allow cysts to open into the ventricular system through a minimally invasive approach8. Besides, endoscopic cystostomy associated with the third ventriculostomy presents a higher success rate than only endoscopic cystostomy for treatment of quadrigeminal cistern arachnoid cysts8.

Gangemi et al., studying 36 quadrigeminal cysts demonstrated a rate of cured or improved patients similar either treated by endoscopic fenestration or traditional surgery, respectively 87.5% (14/16) and 85% (17/20)14. Tamburrini et al., in a recent published series of 26 intra and paraventricular cysts, described the treatment of 11 quadrigeminal cysts8. Six patients were initially treated only by cistoventriculostomy and one patient was submitted to a second endoscopic cyst marsupialization. The other five patients were initially treated by cistoventriculostomy and endoscopic third ventriculostomy and one case required a second endoscopic cyst marsupialization. The nine symptomatic patients of this group had their symptoms resolved after the procedure. Reduction of cyst size was obtained in all eleven patients. In this study there was no mortality or operative morbidity described8.

Neuroendoscopy, however, is not a risk-free procedure. The risks of neuroendoscopy include hemorrhage, with the inherent difficulty of controlling the bleeding, infection, and raised intracranial pressure from too much irrigation without proper venting13,15.

Endoscopic treatment appears as new, safe and secure alternative to open surgery and shunting in the management of quadrigeminal cistern arachnoid cyst. Results in the literature are comparable to the traditional methods with the benefit of low incidence of complications. Although, as a relatively new method, it is necessary a careful follow-up in order to provide evidence of long term efficiency of the endoscopic treatment for this uncommon lesion.

Received 29 May 2008, received in final form 21 July 2008. Accepted 28 July 2008.

Dr. João Paulo Cavalcante de Almeida – Rua Paulo Morais 130 - 60175-175 Fortaleza CE - Brasil. E-mail: jpaulocavalcante@yahoo.com.br

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Publication Dates

  • Publication in this collection
    15 Oct 2008
  • Date of issue
    2008
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