Definition and diagnosis of small fiber neuropathy: consensus from the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology

Definição e diagnóstico de neuropatia de fibras finas: consenso do Departamento Científico de Neuropatias Periféricas da Academia Brasileira de Neurologia.

Francisco de Assis Aquino Gondim Amilton Antunes Barreira Rinaldo Claudino Márcia Waddington Cruz Francisco Marcos Bezerra da Cunha Marcos Raimundo Gomes de Freitas Marcondes Cavalcante França Jr Marcus Vinícius Magno Gonçalves Wilson Marques Jr Osvaldo José Moreira Nascimento Acary Souza Bulle Oliveira Raquel Campos Pereira Camila Pupe Francisco Tellechea Rotta Pedro Schestatsky About the authors


The aim of this study was to describe the results of a Brazilian Consensus on Small Fiber Neuropathy (SFN). Fifteen neurologists (members of the Brazilian Academy of Neurology) reviewed a preliminary draft. Eleven panelists got together in the city of Fortaleza to discuss and finish the text for the manuscript submission. Small fiber neuropathy can be defined as a subtype of neuropathy characterized by selective involvement of unmyelinated or thinly myelinated sensory fibers. Its clinical picture includes both negative and positive manifestations: sensory (pain/dysesthesias/pruritus) or combined sensory and autonomic complaints, associated with an almost entirely normal neurological examination. Standard electromyography is normal. A growing list of medical conditions is associated with SFN. The classification of SFN may also serve as a useful terminology to uncover minor discrepancies in the normal values from different neurophysiology laboratories. Several techniques may disclose sensory and/or autonomic impairment. Further studies are necessary to refine these techniques and develop specific therapies.

small fiber neuropathy; unmyelinated nerve fibers

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