The author has performed 506 transsphenoidal surgeries but has analyzed in this study only 404 cases. There were 396 hypophiseal tumors, 4 intrasellar cysts and 4 empty sellas. Based in the symptoms presented by the patients he describes an "intrasellar syndrome", caracterized by headache, visual disorders and hormonal abnormalities. He calls attention for intrasellar tumors with normal sella, as seen by x-ray. The diagnosis of these tumors were made only by endocrinological studies. At last he shows the advantages of transsphenoidal surgery in this pathology and the exellent results obtained. The mortality of his cases was only 0.2%.