Progressive multifocal leukoencephalopathy in a child with acquired immunodeficiency syndrome (AIDS)

Leucoencefalopatia multifocal progressiva em uma criança com síndrome da imunodeficiênda adquirida

Alexandra Prufer de Q.C. Araujo Heloisa S. Pereira Ricardo H. Oliveira Ana C. Frota José C. Esperança Francisco Duarte About the authors

Abstracts

Progressive multifocal leukoencephalopathy is a rare viral-induced demyelinating disease associated to immunodeficiency. A 10-year-old boy with AIDS is reported, who developed subacute cerebellar signs and symptoms with multiple cranial nerve involvement and dementia. A computed tomography scan revealed a focal nonenhancing area of low attenuation in the cerebellum. On magnetic resonance imaging high signal lesions in T2 weighted sequences were shown. The biopsy of one of those lesions showed the typical histological findings of progressive multifocal leukoencephalopathy. It seems important to consider this diagnosis in children with AIDS who present with progressive neurological features.

progressive multifocal leukoencephalopathy; acquired immunodeficiency syndrome; children; diagnosis


A leucoencefalopatia multifocal progressiva é uma doença desmielinizante rara, induzida por vírus em indivíduos imunodeficientes. Relata-se o caso de um menino de 10 anos de idade com síndrome da imunodeficiência adquirida (SIDA), que desenvolveu quadro subagudo de sinais e sintomas cerebelares com acometimento de nervos cranianos e demência. A tomografia computadorizada de crânio mostrou uma área de hipodensidade não captante no cerebelo. A ressonância magnética evidenciou áreas de hipersinal na seqüência em T2. A biópsia de uma destas lesões revelou os achados histológicos típicos da leucoencefalopatia multifocal progressiva. Esta hipótese, portanto, deve ser considerada em crianças com SIDA que apresentem deterioração neurológica progressiva.

leucoencefalopatia multifocal progressiva; síndrome da imunodeficiência adquirida; criança; diagnóstico


Progressive multifocal leukoencephalopathy in a child with acquired immunodeficiency syndrome (AIDS)

Leucoencefalopatia multifocal progressiva em uma criança com síndrome da imunodeficiênda adquirida

Alexandra Prufer de Q.C. AraujoI; Heloisa S. PereiraII; Ricardo H. OliveiraIII; Ana C. FrotaIII; José C. EsperançaI; Francisco DuarteIV

IChild Neurology and Infectious Diseases Units of the Department of Pediatrics, and Department of Pathology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil: M.D., M.Sc, Assistant Professor

IIChild Neurology and Infectious Diseases Units of the Department of Pediatrics, and Department of Pathology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil: M.D., Postgraduate in Neuropediatrics

IIIChild Neurology and Infectious Diseases Units of the Department of Pediatrics, and Department of Pathology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil: M.D., Pediatrician

IVChild Neurology and Infectious Diseases Units of the Department of Pediatrics, and Department of Pathology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil: M.D., Professor

ABSTRACT

Progressive multifocal leukoencephalopathy is a rare viral-induced demyelinating disease associated to immunodeficiency. A 10-year-old boy with AIDS is reported, who developed subacute cerebellar signs and symptoms with multiple cranial nerve involvement and dementia. A computed tomography scan revealed a focal nonenhancing area of low attenuation in the cerebellum. On magnetic resonance imaging high signal lesions in T2 weighted sequences were shown. The biopsy of one of those lesions showed the typical histological findings of progressive multifocal leukoencephalopathy. It seems important to consider this diagnosis in children with AIDS who present with progressive neurological features.

Key words: progressive multifocal leukoencephalopathy, acquired immunodeficiency syndrome, children, diagnosis.

RESUMO

A leucoencefalopatia multifocal progressiva é uma doença desmielinizante rara, induzida por vírus em indivíduos imunodeficientes. Relata-se o caso de um menino de 10 anos de idade com síndrome da imunodeficiência adquirida (SIDA), que desenvolveu quadro subagudo de sinais e sintomas cerebelares com acometimento de nervos cranianos e demência. A tomografia computadorizada de crânio mostrou uma área de hipodensidade não captante no cerebelo. A ressonância magnética evidenciou áreas de hipersinal na seqüência em T2. A biópsia de uma destas lesões revelou os achados histológicos típicos da leucoencefalopatia multifocal progressiva. Esta hipótese, portanto, deve ser considerada em crianças com SIDA que apresentem deterioração neurológica progressiva.

Palavras-chave: leucoencefalopatia multifocal progressiva, síndrome da imunodeficiência adquirida, criança, diagnóstico.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Aceite: 24-outubro-1996.

Dra. Alexandra Prufer Araujo - Rua Gildásio Amado 55/211 - 22631-020 Rio de Janeiro RJ - Brasil.

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Publication Dates

  • Publication in this collection
    10 Nov 2010
  • Date of issue
    1997
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