Genetic control of central nervous system tumors

THESES

GENETIC CONTROL OF CENTRAL NERVOUS SYSTEM TUMORS (ABSTRACT)^*. DISSERTATION. SÃO PAULO, 1999.

JOSÉ AUGUSTO NASSER DOS SANTOS^**

The recent understanding of molecular biology and cancer has confirmed that cancer is a genetic disease. The aim was establish the definitions and the current concepts of molecular biology and brain tumors.

The first part of this study shows the basic concepts regarding laboratory experiments in nucleic acids and proteins: a) the extraction and cellular preparation from tissue culture or directly from operating room; b) the nucleic acids hybridization; c) the DNA, RNA and proteins analysis in gels. The results obtained in these experiments are analyzed and compared with previous reports. This is the way that new teories are created.

The second part is a review of every molecular mechanism specifically related with brain tumors: a) cytokines or growth factors; b) oncogenes; c) tumor suppressor genes; d) epigenetic events; e) molecular biology of cell cycle; f) tumor cell invasion ; g) the theory of glioma progression.

The third and last part is the most exciting subject that has been developed in this decade. Genetic therapy is a big challenge for every human disease, especially for central nervous system and its tumors. It is brought in a discussion the difficulties about delivery system of genetic particles created or modified by genetic engineering. What are the current protocols running around the world. The preliminary results and conclusions.

This study provides a review of what is happening about molecular biology and brain tumors. It allows professionals related with these or other tumors having the concepts of basic aspects of laboratory experiments, the fusion of these concepts and molecular mechanisms of tumor genetics and finally the main issue after the mapping of every gene related with brain tumors, which is the genetic therapy. Genetic therapy is only in the beginning, by possibly is going to be the real treatment of brain tumors, targeting only the tumor cells and preserving the normal cells.

KEY WORDS: genes, molecular biology, brain tumors, gene therapy.

Corrections

Carpal tunnel syndrome: clinical, epidemiological and nerve conduction studies in 668 cases (Abstract). Dissertation. São José do Rio Preto, 1998. João Aris Kouyoumdjian. Arq Neuropsiquiatr 1998;56:862.

>From - *Síndrome do túnel do carpo: aspectos clínico-epidemiológicos e de condução nervosa em 668 casos (Resumo). Dissertação de Mestrado, Faculdade de Medicina de Ribeirão Preto

To - *Síndrome do túnel do carpo: aspectos clínico-epidemiológicos e de condução nervosa em 668 casos (Resumo). Dissertação de Mestrado, Faculdade de Medicina de São José do Rio Preto

Headache in childhood and adolescence: clinical and laboratory aspects (Abstract). Thesis. Campinas, 1998. Abram Topczewski. Arq Neuropsiquiatr 1998;56:862-863

From - Aeadacae in caildaood and adolescence: clinical and laboratory aspects (Abstract).

To - Headache in childhood and adolescence: clinical and laboratory aspects (Abstract).

*

Controle genético dos tumores do sistema nervoso central (Resumo). Dissertação de Mestrado. Escola Paulista de Medicina , Universidade Federal de São Paulo UNIFESP (Área: Neurocirurgia). Orientador: Antônio de Pádua Bonatelli.

Publication Dates

• Publication in this collection
  06 Nov 2000
• Date of issue
  Mar 1999