Morphological changes in the lateral ventricles choroid plexus of rats (Rattus norvegicus) submitted to the experimental chronic alcoholism

MORPHOLOGICAL CHANGES IN THE LATERAL VENTRICLES CHOROID PLEXUS OF RATS (RATTUS NORVEGICUS) SUBMITTED TO THE EXPERIMENTAL CHRONIC ALCOHOLISM (ABSTRACT)^*. DISSERTATION. BOTUCATU, 1996.

LUÍS FERNANDO TIRAPELLI ^**

Alcoholism is a big social problem. For this reason many searchers are studying this subject in different parts of the world. The aim of this study is to identify the possible morphological changes in the choroid plexus of rats submitted to the experimental chronic alcoholism.

In this search sixty adult rats were used. The animals were arranged in three groups: 1) Control: received tape water in its liquid diet; 2) Alcoholic: received sugar cane brandy 30⁰ G.L. during 300 days; 3) Abstinent: received sugar cane brandy 30⁰ G.L. during 240 days. After 240 days these animals were gradually submitted to less concentrated alcohol dose until the tape water to be its liquid diet again. The sacrifice was performed after 60, 120, 180, 240 and 300 treatment days.

Choroid epithelium hipertrophy was observed at light microscopy level. Ultrastructural changes like swelling and number increase of the Golgi complex; enlargement of the granular endoplasmatic reticulum cisternae as well as the intercelular space, basal complex infolding and connective tissue were observed. Finally, vesicles were observed throughout cytoplasm. In the other hand the abstinent group showed significant regression of the changes above cited.

KEY WORDS: alcoholism, rat, choroid plexus.

** Address: Departamento de Anatomia UNESP, Rubião Júnior, 18618-000 Botucatu SP, Brasil.

*

Alterações morfológicas dos plexos coróides dos ventrículos laterais de ratos (

Rattus norvegicus) submetidos ao alcoolismo crônico experimental (Resumo). Dissertação de Mestrado, Instituto de Biociências da Universidade Estadual Paulista (Área: Anatomia). Orientador: Oisenyl José Tamega.

Publication Dates

• Publication in this collection
  03 Apr 2000
• Date of issue
  Dec 1999