Efeito da terapia fonoaudiológica na qualidade de vida de pacientes com ataxia espinocerebelar tipo 3

Diaféria, Giovana; Bommarito, Silvana; Braga Neto, Pedro; Park, Sung Woo; Padovani, Marina; Haddad, Fernanda; Haddad, Leonardo; Voos, Mariana Callil; Chien, Hsin Fen; Pedroso, José Luiz; Barsottini, Orlando

Giovana Diaféria

conception

execution

organization of patients' evaluation

conception and execution of speech therapy

writing

review

critique of the manuscript

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.

http://orcid.org/0000-0001-9663-0477

Silvana Bommarito

conception

organization of patients' evaluation

conception and execution of speech therapy

writing and review of the manuscript

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Fonoaudiologia, São Paulo SP, Brazil.

http://orcid.org/0000-0003-3708-7878

Pedro Braga Neto

conception and organization of patient's evaluation

review and critique of the manuscript

Universidade Federal do Ceará, Serviço de Neurologia e Neurocirurgia, Fortaleza CE, Brazil.

http://orcid.org/0000-0001-9186-9243

Sung Woo Park

conception

execution

organization of patient's evaluation

review and critique of the manuscript

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, São Paulo SP, Brazil.

http://orcid.org/0000-0003-0157-2863

Marina Padovani

conception and organization of patient's evaluation

conception of speech therapy

review and critique of the manuscript

Faculdade de Ciências Médicas da Santa Casa, Departamento de Fonoaudiologia, São Paulo SP, Brazil.

http://orcid.org/0000-0002-1795-317X

Fernanda Haddad

organization and execution of patients' evaluation

writing

review

critique of the manuscript

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, São Paulo SP, Brazil.

http://orcid.org/0000-0002-5597-1176

Leonardo Haddad

organization and execution of patients' evaluation

review and critique of the manuscript

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, São Paulo SP, Brazil.

http://orcid.org/0000-0003-2988-0139

Mariana Callil Voos

conception and organization of patients' evaluation

review and critique of the manuscript

Universidade Pontífice Católica de São Paulo, Faculdade de Ciências Humanas e da Saúde, São Paulo SP, Brazil.

http://orcid.org/0000-0001-6252-7287

Hsin Fen Chien

conception and organization of patients' evaluation

writing

review

critique of the manuscript

Universidade de São Paulo, Faculdade de Medicina de São Paulo, Departamento de Ortopedia e Traumatologia, São Paulo SP, Brazil.

http://orcid.org/0000-0002-2490-6021

José Luiz Pedroso Address for correspondence José Luiz Pedroso (e-mail: jlpedroso.neuro@gmail.com).

conception

organization

execution of patients' evaluation

writing

review

critique of the manuscript

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.

http://orcid.org/0000-0002-1672-8894

Orlando Barsottini

conception

organization

execution of patients' evaluation

writing

review

critique of the manuscript

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.

http://orcid.org/0000-0002-0107-0831

Address for correspondence José Luiz Pedroso (e-mail: jlpedroso.neuro@gmail.com).

Conflict of Interest

The authors have no conflict of interests to declare.

	STG (n = 25)	CG (n = 23)	p-value
Age (years)	47.72 ± 11.09	46.52 ± 12.01	0.721
Symptoms onset (years)	35.8 ± 11.4	37.5 ± 11.2	0.337
SCA3 duration (years)	14.8 ± 17.3	8.8 ± 15.2	0.12
ICARS scores	31.1 ± 19.8	33.8 ± 20.9	0.643
SARA scores	12.1 ± 8.1	11.4 ± 9.4	0.767

		STG (n = 25)		CG (n = 23)
		Pre-	Post-	Pre-	Post-	p-value
WHOQoL-Bref	Physical	11.88 ± 3.17	12.13 ± 2.78	12.07 ± 2.73	11.17 ± 1.9	0.21
	Psychological	13.46 ± 2.58	13.14 ± 2.62	13.65 ± 2.93	13.38 ± 3.02	0.915
	Social	12.8 ± 3.96	13.23 ± 3.43	14.03 ± 3.31	13.79 ± 3.3	0.265
	Environmental	12.9 ± 2.3	13.2 ± 2.5^Ω Ω post- CG versus STG p < 0.030.	12.34 ± 2.39	11.97 ± 2.51	0.232
LwD	Total	179.12 ± 62.55	129.88 ± 51.42^* * pre- versus post-(STG) p < 0.030; ^Ω Ω post- CG versus STG p < 0.030.	179.0 ± 60.51	196.74 ± 66.09^¥ ¥ pre- CG versus STG p = 0.040;	<0.001
SWAL- QoL	Burden	84.0 ± 21.21	87.6 ± 16.4	78.69 ± 23.98	73.04 ± 30.36	0.161
	Desire	87.73 ± 18.92	88.53 ± 16.94	76.52 ± 19.89	69.26 ± 21.05	0.093
	Duration	76.0 ± 34.15	71.6 ± 35.43	57.82 ± 33.02	53.04 ± 34.17	0.948
	Frequency	81.35 ± 16.25	84.61 ± 11.15	78.53 ± 12.96	75.92 ± 16.75	0.129
	Selection	89.2 ± 17.54	92.4 ± 14.51	83.47 ± 22.28	79.13 ± 22.54	0.095
	Communication	66.0 ± 26.92	79.2 ± 21.19^* * pre- versus post-(STG) p < 0.030;	73.47 ± 16.97	69.56 ± 18.45	0.003
	Fear	69.76 ± 24.85	73.8 ± 23.81	59.78 ± 26.73	54.78 ± 28.18	0.161
	Mental health	81.92 ± 22.6	87.12 ± 19.86	79.3 ± 20.34	72.69 ± 23.92	>0.05
	Social functioning	84.8 ± 24.95	89.92 ± 20.65	83.21 ± 20.06	82.08 ± 22.07	0.279
	Sleep	85.73 ± 17.22	84.8 ± 18.28	76.95 ± 22.85	77.24 ± 24.46	0.767
	Fatigue	62.93 ± 23.57	71.99 ± 19.72	57.34 ± 25.44	57.34 ± 25.28	0.081
	Total	79.04 ± 13.97	82.87 ± 11.91	73.19 ± 13.62	69.47 ± 14.64	0.01
EAT-10	Total	5.16 ± 7.55	2.08 ± 3.85^* * pre- versus post-(STG) p < 0.030;	4.43 ± 9.93	4.95 ± 10.31	0.018

	STG (n = 25)		CG (n = 23)
LwD domains	Pre-	Post-	Pre-	Post-	p-value
1–Speech	3.43 ± 1.29	2.89 ± 1.33	3.35 ± 1.01	3.43 ± 1.1	>0.05
2–Language and cognition	3.46 ± 1.28	2.84 ± 1.17^* Notes: * pre- versus post- (STG) p < 0.002 ^Ω Ω post- (CG) versus post- (STG) p < 0.05;	3.74 ± 1.58	3.89 ± 1.21	0.002
3–Fatigue	3.97 ± 1.5	3.09 ± 1.74^* Notes: * pre- versus post- (STG) p < 0.002	3.71 ± 1.52	4.28 ± 1.45	0.001
4–Effects of emotions	4.27 ± 1.54	3.29 ± 1.35^* Notes: * pre- versus post- (STG) p < 0.002	4.10 ± 1.63	4.25 ± 1.5	0.002
5–Effects of different persons	3.06 ± 1.39	2.14 ± 1.36^* Notes: * pre- versus post- (STG) p < 0.002 ^Ω Ω post- (CG) versus post- (STG) p < 0.05;	3.1 ± 1.43	3.42 ± 1.54	<0.001
6–Effects of different situations	3.34 ± 1.42	2.37 ± 1.32^* Notes: * pre- versus post- (STG) p < 0.002 ^Ω Ω post- (CG) versus post- (STG) p < 0.05;	3.2 ± 1.3	3.85 ± 1.64^▲ ▲ pre- versus post- (CG) p = 0.016.	<0.001
7–Role restrictions	3.62 ± 1.85	2.42 ± 1.47^* Notes: * pre- versus post- (STG) p < 0.002 ^Ω Ω post- (CG) versus post- (STG) p < 0.05;	3.69 ± 1.87	4.06 ± 1.81	<0.001
8–Causing factors	3.68 ± 1.53	2.68 ± 1.37^* Notes: * pre- versus post- (STG) p < 0.002 ^Ω Ω post- (CG) versus post- (STG) p < 0.05;	3.74 ± 1.58	4.13 ± 1.62	<0.001
9–Type of restriction	3.53 ± 1.63	2.43 ± 1.3^* Notes: * pre- versus post- (STG) p < 0.002 ^Ω Ω post- (CG) versus post- (STG) p < 0.05; ^¥ ¥ pre- (CG) versus post- (STG) p = 0.037;	3.63 ± 1.35	3.8 ± 1.58	0.002
10–Strategies	3.78 ± 1.48	2.71 ± 1.43^* Notes: * pre- versus post- (STG) p < 0.002 ^Ω Ω post- (CG) versus post- (STG) p < 0.05;	3.56 ± 1.27	4.00 ± 1.44	<0.001

[1] Address for correspondence José Luiz Pedroso (e-mail: jlpedroso.neuro@gmail.com).

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Efeito da terapia fonoaudiológica na qualidade de vida de pacientes com ataxia espinocerebelar tipo 3

Resumo

Antecedentes

Objetivo

Métodos

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Conclusões