Meningiomas: estudo epidemiologic e anátomo-patológico de 304 casos

Meningiomas: epidemiological and pathological studies of 304 cases

Luiz Fernando Bleggi Torres Luiz Ernani Madalozzo Betina Werner Lúcia de Noronha Graciela V. Vicelli Jacob Bruno C. Medeiros Emiliano N. Vialle Sobre os autores

Resumos

No presente estudo, foram pesquisados os tumores do sistema nervoso central (SNC) diagnosticados na cidade de Curitiba entre 1990 e 1994. Realizaram-se 2371 biópsias de SNC das quais 1340 casos eram neoplasias primárias. Dentre as neoplasias primárias de SNC 304 (22,6%) eram meningiomas. Duzentos e nove meningiomas ocorreram em mulheres (68,7%) e 95 ocorreram em homens (31,3%). As idades variaram de 3 a 90 anos, com média de 45,8 anos. Duzentos e oitenta meningiomas localizavam-se no cérebro, 10 na medula espinhal, 9 no cerebelo e 5 na emergência de nervos cranianos. Na classificação histológica verificou-se que 294 (96,7%) eram do tipo clássico, 6 malignos (ou anaplásicos), 3 atípicos e 1 papilar. No grupo dos meningiomas clássicos 267 eram meningoteliais, 10 psamomatosos, 5 fibroblásticos, 5 microcísticos, 5 transicionais e 2 angiomatoses. Os autores concluem que as neoplasias meníngeas representaram o grupo mais freqüente de tumores primários do SNC e apresentaram características epidemiológicas e anátomo-patológicas similares às da literatura mundial, na qual é dada ênfase à dificuldade de estabelecer critérios biológicos e histológicos de malignidade neste grupo de tumores.

tumor cerebral; meningioma; epidemiologia; histopatologia


The authors have retrospectively reviewed all tumors of central nervous system (CNS) operated at the most important neurosurgery hospitals of Curitiba in a 5-year period (1990-1994) and found 304 (22.4%) cases of meningioma. Age mean of the patients was 48.5 years, with a range of 3 to 90 years. A marked female preponderance (68.7%) was noted. The most common tumor location was brain (n=280) and the remaining cases occurred in spinal cord (n=10), cerebellum (n=9) and cranial nerves (n=5). Histologically, there were 294 (96.7%) meningiomas of the classical type, six malignant or anaplastic, three atypical and one papillary. Two hundred and sixty seven classical meningiomas were from the meningotelial subtype, ten psamomatousos, five fibroblastic, five microcystic, five transicional and two angiomatous. The authors conclude that meningiomas are one of the most common group of primary neoplasias of CNS and the definition of malignancy in those tumors is beset by frequent discordance between histologic and biologic features.

brain tumor; meningioma; epidemiology; histopathology


Meningiomas: estudo epidemiologic e anátomo-patológico de 304 casos

Meningiomas: epidemiological and pathological studies of 304 cases

Luiz Fernando Bleggi TorresI; Luiz Ernani MadalozzoII; Betina WernerI; Lúcia de NoronhaI; Graciela V. Vicelli JacobI; Bruno C. MedeirosI; Emiliano N. VialleI

ISeção de Neuropatologia e Microscopia Eletrônica do Serviço de Anatomia Patológica

IIServiço de Neurocirurgia do Hospital de Clínicas de Curitiba, Universidade Federal do Paraná. (UFPR)

RESUMO

No presente estudo, foram pesquisados os tumores do sistema nervoso central (SNC) diagnosticados na cidade de Curitiba entre 1990 e 1994. Realizaram-se 2371 biópsias de SNC das quais 1340 casos eram neoplasias primárias. Dentre as neoplasias primárias de SNC 304 (22,6%) eram meningiomas. Duzentos e nove meningiomas ocorreram em mulheres (68,7%) e 95 ocorreram em homens (31,3%). As idades variaram de 3 a 90 anos, com média de 45,8 anos. Duzentos e oitenta meningiomas localizavam-se no cérebro, 10 na medula espinhal, 9 no cerebelo e 5 na emergência de nervos cranianos. Na classificação histológica verificou-se que 294 (96,7%) eram do tipo clássico, 6 malignos (ou anaplásicos), 3 atípicos e 1 papilar. No grupo dos meningiomas clássicos 267 eram meningoteliais, 10 psamomatosos, 5 fibroblásticos, 5 microcísticos, 5 transicionais e 2 angiomatoses. Os autores concluem que as neoplasias meníngeas representaram o grupo mais freqüente de tumores primários do SNC e apresentaram características epidemiológicas e anátomo-patológicas similares às da literatura mundial, na qual é dada ênfase à dificuldade de estabelecer critérios biológicos e histológicos de malignidade neste grupo de tumores.

Palavras-chave: tumor cerebral, meningioma, epidemiologia, histopatologia.

ABSTRACT

The authors have retrospectively reviewed all tumors of central nervous system (CNS) operated at the most important neurosurgery hospitals of Curitiba in a 5-year period (1990-1994) and found 304 (22.4%) cases of meningioma. Age mean of the patients was 48.5 years, with a range of 3 to 90 years. A marked female preponderance (68.7%) was noted. The most common tumor location was brain (n=280) and the remaining cases occurred in spinal cord (n=10), cerebellum (n=9) and cranial nerves (n=5). Histologically, there were 294 (96.7%) meningiomas of the classical type, six malignant or anaplastic, three atypical and one papillary. Two hundred and sixty seven classical meningiomas were from the meningotelial subtype, ten psamomatousos, five fibroblastic, five microcystic, five transicional and two angiomatous. The authors conclude that meningiomas are one of the most common group of primary neoplasias of CNS and the definition of malignancy in those tumors is beset by frequent discordance between histologic and biologic features.

Key words: brain tumor, meningioma, epidemiology, histopathology.

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Agradecimentos - Agradecemos aos Drs. Acir Mulinari, José Ederaldo Q. Telles, Elizabete S. Gugelmin e Lysandro A. Sampaio pela permissão para pesquisar os arquivos dos Serviços de Anatomia Patológica; à bióloga Daniele Martins da Costa e ao Centro de Patologia de Curitiba pelas preparações imuno-histoquímicas, e às biólogas Fádua de Queiroz e Maria Iolanda Sanches pelas preparações de microscopia eletrônica. Este estudo foi realizado com apoio do Centro de Microscopia Eletrônica da UFPR e do CNPq. Registro no Banpesq n° 94003830.

Aceite: 20-maio-1996.

Dr. Luiz Fernando Bleggi Torres - Seção de Neuropatologia e Microscopia Eletrônica do Serviço de Anatomia Patológica, Hospital de Clínicas - Rua General Carneiro 181 - 80060-900 Curitiba PR - Brasil. FAX: 041 2642513.

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Datas de Publicação

  • Publicação nesta coleção
    12 Nov 2010
  • Data do Fascículo
    Dez 1996

Histórico

  • Recebido
    20 Maio 1996
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