Bleuler's concept of schizophrenia is up till now the most widely accepted by the investigators. In spite of trends of research clearly biological or psychological, there is a tendency for a clear cut psychobiological approach or, even better, for a multidisciplinary study of the problem. In this paper are discussed the results obtained by three groups of researchers. One deals with biological variables while the other two work with interpersonal relations, mostly intrafamilial ones. The first is the Tulane group. Heath, in charge of the project, has stressed that abnormal bioelectrical activity of certain subcortical areas, mainly the septal region and the hippocampus, is related to postural and behavioral variations in monkeys and humans. The isolation of a protein from the serum of schizophrenic patients, that produces schizophrenic-like symptoms in voluntaries when injected with this substance, tries to prove the existence of a metabolic error, probably enzymatic, in these patients. The other two groups (Bethesda and Yale), with Bowen and Lidz, are studying characteristics of the functions and interrelations in families with one schizophrenic patient mainly adolescent. The conclusions arrived by both groups of researchers support the concept of a schizophrenic family vs. the classical concept of a schizophrenic patient.