Diffusion tensor magnetic resonance imaging may show abnormalities in the normal-appearing cervical spinal cord from patients with multiple sclerosis

Miraldi, Fernanda; Lopes, Fernanda Cristina Rueda; Costa, João Victor Altamiro; Alves-Leon, Soniza Vieira; Gasparetto, Emerson Leandro

doi:10.1590/0004-282X20130099

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Articles • Arq. Neuro-Psiquiatr. 71 (9A) • Sept 2013 • https://doi.org/10.1590/0004-282X20130099 copy

Diffusion tensor magnetic resonance imaging may show abnormalities in the normal-appearing cervical spinal cord from patients with multiple sclerosis

Exames de imagem por tensor de difusão podem mostrar alterações na coluna cervical aparentemente normal em pacientes com esclerose múltipla

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective

This study aims to evaluate “in vivo” the integrity of the normal-appearing spinal cord (NASC) in patients with multiple sclerosis (MS) compared to controls, using diffusion tensor MR imaging.

Methods

We studied 32 patients with MS and 17 without any neurologic disorder. Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) were calculated within regions of interest at C2 and C7 levels in the four columns of the spinal cord.

Results

At C2, FA value was decreased in MS patients. Besides, RD value was higher in MS than in controls. At C7, MD values were increased in MS.

Conclusion

The NASC in the right column of the cervical spinal cord showed abnormal FA, RD and MD values, which is possibly related to demyelination, since the FA abnormality was related to the RD and not to the AD.

diffusion tensor imaging; multiple sclerosis; cervical spinal cord

C2	MS versus CONTROLS
	Right					Left
		FA	AD	RD	MD		FA	AD	RD	MD
MS - Mean±SD	n=23	0.59±0.20	2.19±0.45	0.71±0.57	1.36±0.45	n=28	0.65±0.23	2.29±0.37	0.75±0.57	1.29±0.45
CONT - Mean±SD	n=17	0.75±0.14	2.43±0.98	0.50±0.29	1.08±0.36	n=17	0.72±0.18	2.25±0.58	0.62±0.50	1.16±0.50
p-value		0.01*	0.44	0.03*	0.14		0.48	0.85	0.59	0.57
C2	Anterior					Posterior
C2		FA	AD	RD	MD		FA	AD	RD	MD
MS - Mean±SD	n=30	0.58±0.06	2.15±0.43	0.76±0.24	1.24±0.31	n=26	0.64±0.23	2.32±0.26	0.78±0.57	1.32±0.45
CONT - Mean±SD	n=17	0.63±0.08	1.99±0.38	0.67±0.22	1.20±0.29	n=17	0.76±0.12	2.25±0.59	0.54±0.39	1.13±0.41
p-value		0.08	0.32	0.34	0.34		0.14	0.7	0.24	0.32
C7	Right					Left
C7		FA	AD	RD	MD		FA	AD	RD	MD
MS -Mean±SD	n=29	0.51±0.18	2.01±0.61	0.79±0.58	1.19±0.57	n=32	0.62±0.13	2.04±0.39	0.68±0.28	1.13±0.29
CONT - Mean±SD	n=17	0.71±0.12	2.05±0.31	0.67±0.52	1.00±0.20	n=17	0.63±0.09	2.03±0.37	0.79±0.51	1.21±0.38
p-value		0.09	0.14	0.58	0.03*		0.48	0.85	0.59	0.57
C7		Anterior				Posterior
C7		FA	AD	RD	MD		FA	AD	RD	MD
MS -Mean±SD	n=32	0.57±0.11	2.15±0.43	0.76±0.24	1.24±0.31	n=31	0.52±0.11	2.40±0.52	1.05±0.41	1.49±0.43
CONT - Mean±SD	n=17	0.58±0.12	2.06±0.67	0.80±0.56	1.22±0.57	n=17	0.57±0.15	2.53±0.47	0.99±0.44	1.51±0.42
p-value		0.93	0.94	0.54	0.61		0.35	0.52	0.23	0.95

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[1] Correspondence: Fernanda Miraldi; Rua Rodolpho Paulo Rocco 255; 21941-913 Rio de Janeiro RJ - Brasil; E-mail: fernandamiraldi@hotmail.com