Report of a severe case of meningoencephalitis on a seventy six year old patient, who was treated and cured by intra-thecal and intra-muscular injections of chloramphenicol. The clinical process of meningoencephalitis started after a gastro-intestinal toxic infection. The cerebrospinal fluid examination showed a meningitic process by E. coli. It was prescribed chloramphenicol therapy by intra-thecal way, in daily doses of 3 mg/kg, corresponding to 2.5 ml of chloramphenicol succinate solution at 10% or 250 mg of the salt. At the same time, chloramphenicol succinate was administered by muscle in the daily dose of 1 g divided in four doses. After 23 days of treatment it was obtained clinical cure followed by improvement of the spinal fluid, which showed a decrease from 5,172 to 8 cells and complete negative bacterioscopic findings. After a one year follow-up the patient is quite well and is without neuro-psychiatric sequelae.