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Severity of liver disease and quality of life in liver transplantation

Abstract

Objective

To analyze the influence of liver disease severity on the quality of life of patients before and after liver transplantation.

Methods

A descriptive study with 150 liver transplant recipients over 18 years of age. Severity was assessed using Child and MELD, and the Liver Disease Quality of Life was administered. The t-test or Mann-Whitney test was used to compare the mean values of the domains, and an ANOVA or Kruskal-Wallis test was used for between group comparison.

Results

Prior to transplantation, patients with Child class C had lower quality of life scores than those with Child class A. Patients with MELD lower than or equal to 15 had a significant increase of mean values in ten domains, whereas patients with MELD scores greater than 15 had increased mean values in 12 domains.

Conclusion

There was a negative influence of severity on quality of life prior to transplantation, according to Child-Turcotte-Pugh. The MELD did not interfere significantly in the post-transplantation outcomes, even though the mean values increased.

Liver transplantation; Quality of life; Nursing assessment; Patient acuity; Preoperative period; Postoperative period

Escola Paulista de Enfermagem, Universidade Federal de São Paulo R. Napoleão de Barros, 754, 04024-002 São Paulo - SP/Brasil, Tel./Fax: (55 11) 5576 4430 - São Paulo - SP - Brazil
E-mail: actapaulista@unifesp.br