S4 compared to other stages |
No |
All |
miR-1291, miR-323, miR-631, miR130a, miR-433, miR-489, miR382, miR378 |
GnRH signaling pathway, FoxO signaling pathway, Vascular smooth muscle contraction, Signaling pathways puripotency of stem cells, Wnt signaling pathway |
Hamdi et al. (2021)Hamdi M, Cañon‐Beltrán K, Mazzarella R, Cajas YN, Leal CLV, Gutierrez‐Adan A, Silveira JC, Rizos D. Characterization and profiling analysis of bovine oviduct and uterine extracellular vesicles and their miRNA cargo through the estrous cycle. FASEB J. 2021;35(12):e22000. http://dx.doi.org/10.1096/fj.202101023R. PMid:34731497. http://dx.doi.org/10.1096/fj.202101023R...
|
S2 |
Yes |
Isthmus |
miR-126-5p, miR129, miR-140, miR-188, miR-219, miR345-3p, miR-4523, miR-760-3p |
Metabolic pathways, PI3K-Akt signaling pathway, MAPK signaling pathway, Endocytosis, Ras signaling pathway |
Mazzarella et al. (2021)Mazzarella R, Bastos NM, Bridi A, del Collado M, Andrade GM, Pinzon J, Prado CM, Silva LA, Meirelles FV, Pugliesi G, Perecin F, Silveira JC. Changes in oviductal cells and small extracellular vesicles miRNAs in pregnant cows. Front Vet Sci. 2021;8:639752. http://dx.doi.org/10.3389/fvets.2021.639752. PMid:33748215. http://dx.doi.org/10.3389/fvets.2021.639...
|
No |
miR-331-5p |
cAMP signaling pathway, Insulin signaling pathway, Regulation of actin cytoskeleton, Wnt signaling pathway, Focal adhesion |
S1 and S4 |
No |
All |
miR-10b-5p |
Pyrimidine metabolism |
Almiñana et al. (2018)Almiñana C, Tsikis G, Labas V, Uzbekov R, Silveira JC, Bauersachs S, Mermillod P. Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo. BMC Genomics. 2018;19(1):622. http://dx.doi.org/10.1186/s12864-018-4982-5. PMid:30134841. http://dx.doi.org/10.1186/s12864-018-498...
|
miR-423-5p |
Fatty acid biosynthesis, Fatty acid metabolism |
miR-449a |
Carbon metabolism, HIF-1 signaling pathway |
miR-375 |
Hippo signaling pathway, Amino sugar and nucleotide sugar metabolism |
miR-24-3p |
Fatty acid biosynthesis, Vitamin B6 metabolism, Endocytosis, Hippo signaling pathway, Bacterial invasion of epithelial cells |
miR-148a-3p |
Fatty acid biosynthesis, Steroid biosynthesis, Oocyte meiosis, Progesterone mediated oocyte maturation, FoxO signaling pathway |
miR-429 |
Axon guidance, FC gamma R-mediated phagocytosis, Steroid biosynthesis, Progesterone mediated oocyte maturation, Gap junction |
miR-34b-3p |
Glycosaminoglycan degradation |
miR-200b-3p |
Ras signaling pathway, Neurotrophin signaling pathway |
miR-92a-3p |
Cell cycle, Adherens junction, Thyroid hormone signaling pathway, FoxO signaling pathway, RNA transport, Signaling pathways regulating pluripotency of stem cells |
miR-151a-3p |
Biosynthesis of unsaturated fatty acids, Fatty acid metabolism |
miR-30d-5p |
Mucin type O-, Glycan biosynthesis, Oocyte meiosis, Ubiquitin mediated proteolysis, mRNA surveillance pathway |
miR-125b-5p |
ErbB signaling pathway, Regulation of actin cytoskeleton |