Chowdhury, S.S. et al., 2016 [1717 Chowdhury SS et al., Paternal High Fat Diet in Rats Leads to Renal Accumulation of Lipid and Tubular Changes in Adult Offspring. Nutrients, 2016. 8(9).10.3390/nu8090521. https://doi.org/10.3390/nu8090521...
] |
9/20 |
Kidney injury, increased triglyceride content, tubular damage, and absence of brush border |
*This gender was not reported on/examined in this study |
Fontelles, C.C. et al., 2016 [1818 Fontelles CC et al., Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets. Breast Cancer Res, 2016;18(1):71. 10.1186/s13058-016-0729-x. https://doi.org/10.1186/s13058-016-0729-...
] |
12/20 |
*This gender was not reported on/examined in this study
|
Increased risk of breast cancer |
Fullston, T. et al., 2012 [2020 Fullston T et al., Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice. Hum. Reprod., 2012.27(5):1391-400.10.1093/humrep/des030. https://doi.org/10.1093/humrep/des030...
] |
10/20 |
Reduced sperm function, including reduced motility |
Reduced ovarian function and increased adiposity |
Fullston, T. et al., 2013 [2222 Fullston T et al., Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB J, 2013;27(10):4226-43.10.1096/fj.12-224048. https://doi.org/10.1096/fj.12-224048...
] |
13/20 |
Decreased glucose tolerance and altered insulin sensitivity |
Decreased glucose tolerance and altered insulin sensitivity |
Fullston, T. et al., 2015 [1919 Fullston T, et al., Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cells. J. Assist. Reprod. Genet., 2015;32(5):725-35.10.1007/s10815-015-0470-x. https://doi.org/10.1007/s10815-015-0470-...
] |
11/20 |
*This gender was not reported on/examined in this study
|
Accumulation of lipid droplets in ovaries and alterations in ovarian gene expression |
Fullston, T. et al., 2016 [2121 Fullston T et al., Sperm microRNA Content Is Altered in a Mouse Model of Male Obesity, but the Same Suite of microRNAs Are Not Altered in Offspring's Sperm. PLoS One, 2016;11(11):e0166076. 10.1371/journal.pone.0166076. https://doi.org/10.1371/journal.pone.016...
] |
10/20 |
No changes in the sperm microRNA content of offspring |
*This gender was not reported on/examined in this study |
Lecomte, V. et al., 2016 [2323 Lecomte V et al., Effects of paternal obesity on growth and adiposity of male rat offspring. Am. J. Physiol. Endocrinol. Metab, 2017;312(2):E117-25. 10.1152/ajpendo.00262.2016 https://doi.org/10.1152/ajpendo.00262.20...
] |
15/20 |
Growth deficit, reduced circulating levels of GH and IGF-I, decreased expression of growth markers in muscle (8 weeks), decreased expression of adipogenesis markers in adipose tissue, increased triglyceride content and expression of lipogenic genes in muscle |
*This gender was not reported on/examined in this study |
Masuyama, H. et al., 2016 [2424 Masuyama H et al., The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters. Am. J. Physiol. Endocrinol. Metab. 2016;311(1):E236-45. 10.1152/ajpendo.00095.2016. https://doi.org/10.1152/ajpendo.00095.20...
] |
11/20 |
Increased HOMA IR, glucose, insulin, total triglycerides, and leptin, decreased serum levels of adiponectin, decreased adiponectin gene expression, and elevated leptin gene expression |
Increased HOMA IR, glucose, insulin, total triglycerides, and leptin, decreased serum levels of adiponectin, decreased adiponectin gene expression, and elevated leptin gene expression |
McPherson, N.O. et al., 2014 [2929 McPherson NO et al. Obese father's metabolic state, adiposity, and reproductive capacity indicate son's reproductive health. Fertil Steril. 2014;101(3):865-73.] |
13/20 |
Reduced sperm function, including reduced motility |
*This gender was not reported on/examined in this study |
Ng, S.F. et al., 2010 [3030 Ng SF et al. Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature. 2010;467(7318):963-6.] |
|
*This gender was not reported on/examined in this study
|
Early onset of impaired insulin secretion and glucose tolerance |
Ng, S.F. et al., 2014 [2525 Ng SF et al., Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring. FASEB J, 2014. 28(4): p. 1830-41.10.1096/fj.13-244046 https://doi.org/10.1096/fj.13-244046...
] |
9/20 |
*This gender was not reported on/examined in this study
|
Alterations in RpWAT gene expression and in the pancreatic islets, increased susceptibility to obesity and diabetes |
Ornellas, F. et al., 2015 [2626 Ornellas F et al., Programming of obesity and comorbidities in the progeny: lessons from a model of diet-induced obese parents. PLoS One, 2015;10(4):e0124737. 10.1371/journal.pone.0124737. https://doi.org/10.1371/journal.pone.012...
] |
13/20 |
Inflammation of the hypothalamus without increase in BM or food intake |
Inflammation of the hypothalamus without increase in BM or food intake |
Ornellas, F. et al., 2016 [2727 Ornellas F et al., Combined parental obesity augments single-parent obesity effects on hypothalamus inflammation, leptin signaling (JAK/STAT), hyperphagia, and obesity in the adult mice offspring. Physiol. Behav., 2016;153:47-55.10.1016/j.physbeh.2015.10.019. https://doi.org/10.1016/j.physbeh.2015.1...
] |
11/20 |
Increased fasting glucose, decreased glucose tolerance, and hepatic steatosis |
Increased fasting glucose, decreased glucose tolerance, and hepatic steatosis |
Stanford, K.I. et al., 2018 [3131 Stanford KI et al. Paternal Exercise Improves Glucose Metabolism in Adult Offspring. Diabetes. 2018;67(12):2530-40.] |
15/20 |
Impaired glucose tolerance, increased percentage of fat mass |
Impaired glucose tolerance, increased percentage of fat mass |
Youngson, N.A. et al., 2016 [2828 Youngson NA et al., Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring. Asian. J. Androl. 2016;18(6):930-6.10.4103/1008-682X.163190. https://doi.org/10.4103/1008-682X.163190...
] |
13/20 |
No changes in the sperm microRNA content of offspring |
*This gender was not reported on/examined in this study |
Zhou, Y. et al., 2018 [3232 Zhou Y et al. Diet-Induced Paternal Obesity Impairs Cognitive Function in Offspring by Mediating Epigenetic Modifications in Spermatozoa. Obesity (Silver Spring). 2018;26(11):1749-57.] |
13/20 |
Cognitive impairments |
*This gender was not reported on/examined in this study |