Antibacterial and Cytotoxic Effects of Cyclodextrin-Triazole-Titanium Based Nanocomposite

HIGHLIGHTS

Observation of the antibacterial and cytotoxic effects of CD.COM due to the synergy between cyclodextrin, triazole and TiO₂ NPs.

The antibacterial activity of CD.COM against both gram positive and gram negative bacteria.

The CD.COM cytotoxicity against cancer cells and compatibility with fibroblast cells.

Abstract

In this paper, the antibacterial activity of triazole functionalized cyclodextrin (CD.Click) and cyclodextrin-triazole-titanium based nanocomposite (CD.COM) was evaluated. The results indicated that CD.Click and CD.COM perform a wide range of antibacterial activity against both gram positive (Staphylococcus aureus and Bacillus subtilis) and gram negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. The cytotoxic effect of CD.COM was investigated in vitro on cancerous cell lines (cervical cancer, breast carcinoma and sarcoma osteogenic) and fibroblast cells by MTT assay. The cell viability evaluation confirmed that the growth of cancerous cells is inhibited in a dose and time dependent way without any significant effect on the normal fibroblast cells.

Keywords:
TiO₂; Triazole; β-Cyclodextrin; antibacterial; cytotoxic

GRAPHICAL ABSTRACT