Does bariatric surgery reduce inflammatory activation in obesity? Evidence by complement fraction C5a

Introduction:  Obesity is a state of chronic low-grade inflammation, which plays a central role in the genesis of several metabolic and cardiovascular comorbidities. Among the mediators of this process, the complement system stands out, whose activation contributes decisively to the perpetuation of the inflammatory response.

Objective:  To review the changes in the serum concentration of the C5a fraction of the complement system in obese patients undergoing Roux-en-Y gastric bypass, and to investigate their possible correlation with changes in metabolic parameters.

Method:  Integrative review based on online search obtained through virtual platforms with a search for DECs descriptors “complement, C5a, obesity and inflammation” related to the theme, with AND or OR search, considering the title and/or abstract. The material for reading and analysis was selected from the SciELO, Google Scholar, Pubmed and Scopus platforms.

Result  Considering only those that had a greater relationship with the theme, 31 articles were read in full.

Conclusion:  Bariatric surgery promotes a significant reduction in serum C5a levels, suggesting attenuation of inflammator y activation mediated by the complement system.

KEYWORDS:
Complement; C5a; Obesity; Inflammation