How to speed up the repair of skin wounds? Evidence with stem cells and amniotic membrane

Introduction:  The skin plays a fundamental role as a biological barrier, acting in the protection of the body against physical, chemical and microbiological agents of the external environment. In this context, approaches based on tissue engineering have been widely investigated, especially those that combine the use of stem cells and biomaterials, such as the amniotic membrane.

Objective:  This review aimed to critically analyze the evidence available in the literature on the effects of the application of bone marrow-derived mononuclear stem cells, alone or in association with the decellularized amniotic membrane.

Method:  Integrative review conducted with methodological rigor, gathering evidence for clinical practice. It was performed in the PubMed and Medline databases, using the Boolean operator “AND” to associate relevant descriptors.

Results:  97 articles were included that were related to the descriptors mentioned.

Conclusion:  The findings demonstrate that mononuclear stem cells associated with the amniotic membrane improve healing in later stages of repair, and may generate less fibrosis, better aesthetic and functional quality of the scar.

KEYWORDS:
Wound healing; Mononuclear stem cells; Amniotic membrane; Regenerative medicine