CSF3R/CD114: a predictor related to worse survival in gliomas

Introduction:  Gliomas are the most frequent primary brain tumors, accounting for more than 80% of all primary neoplasms of the central nervous system. These tumors are classified into different histological subtypes, the main ones being astrocytoma, oligodendroglioma, and glioblastoma. Among them, glioblastoma stands out as the most common and aggressive subtype, associated with a poor prognosis, even in the face of multimodal therapeutic approaches that combine surgical resection, radiotherapy, and chemotherapy with temozolomide

Objective:  To analyze the association of CD114 expression with survival in patients with glioma.

Method:  The articles were selected by searching the following databases: Virtual Health Library (VHL), Medline, PubMed, and SciELO. The descriptors used were “CSF3R, CD114, colony-stimulating factor of granulocytes, glioma, glioblastoma, brain tumor”, performing advanced search by combining them with the Boolean operator AND.

Result:  A total of 95 articles were analyzed.

Conclusion:  There is an association between high expression of CSF3R/CD114 with worst prognosis of patients, reflected by the reduction in overall survival in different types of glial tumors.

KEYWORDS:
CSF3R; CD114; Granulocyte colony-stimulating factor; Glioma; Glioblastoma; Braintumor