Aly et al., 2016Aly, E., López-Nicolás, R., Darwish, A. A., Frontela-Saseta, C., & Ros-Berruezo, G. (2016). Supplementation of infant formula with recombinant human lactoferrin and/or galactooligosaccharides increases iron bioaccessibility as measured by ferritin formed in Caco-2 cell model. Food Research International, 89(3), 1048-1055. http://dx.doi.org/10.1016/j.foodres.2016.08.030 http://dx.doi.org/10.1016/j.foodres.2016...
|
Fe |
Solubilidade e célula Caco-2 |
Amostras preparadas em laboratório |
Pepsina, pancreatina e sal biliar |
AAS |
Bermejo et al., 2002Bermejo, P., Peña, E. M., Domínguez, R., Bermejo, A., Cocho, J. A., & Fraga, J. M. (2002). Iron and zinc in hydrolised fractions of human milk and infant formula using an in vitro method. Food Chemistry, 77(3), 361-369. http://dx.doi.org/10.1016/S0308-8146(02)00111-5 http://dx.doi.org/10.1016/S0308-8146(02)...
|
Fe e Zn |
Solubilidade |
Leite materno; 12 FI comerciais |
Pepsina, pancreatina |
AAS |
Bosscher et al., 2001Bosscher, D., Van Caillie-Bertrand, M., Robberecht, H., Van Dyck, K., Van Cauwenbergh, R., & Deelstra, H. (2001). In vitro availability of calcium, iron, and zinc from first-age infant formulae and human milk. Journal of Pediatric Gastroenterology and Nutrition, 32(1), 54-58. PMid:11176326. http://dx.doi.org/10.1097/00005176-200101000-00016 http://dx.doi.org/10.1097/00005176-20010...
|
Ca, Fe e Zn |
Dialisabilidade (diálise em fluxo contínuo) |
Leite materno; FI preparadas em Laboratório |
Pepsina, pancreatina e sal biliar |
FAAS |
Bosscher et al., 2003Bosscher, D., Van Caillie-Bertrand, M., Van Cauwenbergh, R., & Deelstra, H. (2003). Availabilities of calcium, iron, and zinc from dairy infant formula is affected by soluble dietary fibers and modified starch fractions. Nutrition, 19(7-8), 641-645. PMid:12831951. http://dx.doi.org/10.1016/S0899-9007(03)00063-7 http://dx.doi.org/10.1016/S0899-9007(03)...
|
Ca, Fe e Zn |
Dialisabilidade (diálise em fluxo contínuo) |
Leite materno; FI padrão e especiais (com espessante) |
Pepsina, pancreatina e sal biliar |
FAAS |
Silva et al., 2013aSilva, E. N., Leme, A. B. P., Cidade, M., & Cadore, S. (2013a). Evaluation of the bioaccessible fractions of Fe, Zn, Cu and Mn in baby foods. Talanta, 117, 184-188. PMid:24209328. http://dx.doi.org/10.1016/j.talanta.2013.09.008 http://dx.doi.org/10.1016/j.talanta.2013...
|
Cu, Fe, Mn e Zn |
Solubilidade |
Matrizes variadas; material de referência certificado FI |
α-amilase, Pepsina, pancreatina e sal biliar; Ureia; Glucose; mucina; alumina |
ICP-MS |
Domínguez et al., 2004Domínguez, R., Barreiro, T., Sousa, E., Bermejo, A., Cocho, J. A., Fraga, J. M., & Bermejo, P. (2004). Study of the effect of different iron salts used to fortify infant formulas on the bioavailability of trace elements using ICP-OES. International Dairy Journal, 14(12), 1081-1087. http://dx.doi.org/10.1016/j.idairyj.2004.03.011 http://dx.doi.org/10.1016/j.idairyj.2004...
|
Cu, Fe e Zn |
Dialisabilidade |
FI modificada em laboratório |
Pepsina e pancreatina |
ICP OES |
Drago & Valencia, 2004Drago, S. R., & Valencia, M. E. (2004). Influence of components of infant formulas on in vitro iron, zinc, and calcium availability. Journal of Agricultural and Food Chemistry, 52(10), 3202-3207. PMid:15137876. http://dx.doi.org/10.1021/jf035191e http://dx.doi.org/10.1021/jf035191e...
|
Ca, Fe e Zn |
Dialisabilidade |
FI preparada em laboratório |
Pepsina, pancreatina e sal biliar |
FAAS |
Frontela et al., 2008Frontela, C., Haro, J. F., Ros, G., & Martínez, C. (2008). Effect of dephytinization and follow-on formula addition on in vitro iron, calcium, and zinc availability from infant cereals. Journal of Agricultural and Food Chemistry, 56(10), 3805-3811. PMid:18433137. http://dx.doi.org/10.1021/jf073424m http://dx.doi.org/10.1021/jf073424m...
|
Ca, Fe e Zn |
Solubilidade e dialisabilidade |
Cereal infantil reconstituído em FI ou água |
Pepsina, pancreatina e sal biliar |
FAAS |
García et al., 1998García, R., Alegría, A., Barberá, R., Farre, R., & Lagarda, M. J. (1998). Dialyzability of iron, zinc, and copper of different types of infant formulas marketed in Spain. Biological Trace Element Research, 65(1), 7-17. PMid:9877533. http://dx.doi.org/10.1007/BF02784110 http://dx.doi.org/10.1007/BF02784110...
|
Fe, Cu e Zn |
Dialisabilidade |
6 tipos diferentes de FI comerciais (n = 18) |
Pepsina, pancreatina e sal biliar |
FAAS; ETAAS; Espectroscopia UV/visível |
Glahn et al., 1998Glahn, R. P., Lai, C., Hsu, J., Thompson, J. F., Guo, M., & Van Campen, D. R. (1998). Decreased Citrate Improves iron availability from infant formula: Application of an in vitro digestion/caco-2 cell culture model. The Journal of Nutrition, 128(2), 257-264. PMid:9446853. http://dx.doi.org/10.1093/jn/128.2.257 http://dx.doi.org/10.1093/jn/128.2.257...
|
Fe |
Célula Caco-2 |
Leite materno; FI padrão |
Pepsina, pancreatina e sal biliar |
59Fe em um contador gama automático |
Gomez, Perez-Corona & Madrid, 2016Gomez, B. G., Perez-Corona, M. T., & Madrid, Y. (2016). Availability of Zinc from infant formula by in vitro methods (solubility and dialyzability) and size-exclusion chromatography coupled to inductively coupled plasma-mass spectrometry. Journal of Dairy Science, 99(12), 9405-9414. PMid:27771091. http://dx.doi.org/10.3168/jds.2016-11405 http://dx.doi.org/10.3168/jds.2016-11405...
|
Zn |
Solubilidade e Dialisabilidade |
6 diferentes FI comerciais |
α-amilase, Pepsina, pancreatina e sal biliar |
FAAS; Espectroscopia UV/visível e ICP-MS |
Jovaní et al., 2000Jovaní, M., Alegría, A., Barberá, R., Farré, R., Lagarda, M. J., & Clemente, G. (2000). Effect of proteins, phytates, ascorbic acid and citric acid on dialysability of calcium, iron, zinc and copper in soy-based infant formulas. Die Nahrung, 44(2), 114-117. PMid:10795579. http://dx.doi.org/10.1002/(SICI)1521-3803(20000301)44:2<114::AID-FOOD114>3.0.CO;2-N http://dx.doi.org/10.1002/(SICI)1521-380...
|
Ca, Cu, Fe e Zn |
Dialisabilidade |
8 diferentes FI comerciais |
Pepsina, pancreatina e sal biliar |
FAAS; ETAAS |
Jovaní et al., 2001Jovaní, M., Barberá, R., Farré, R., & Martín de Aguilera, E. (2001). Calcium, iron, and zinc uptake from digests of infant formulas by caco-2 cells. Journal of Agricultural and Food Chemistry, 49(7), 3480-3485. PMid:11453795. http://dx.doi.org/10.1021/jf010106t http://dx.doi.org/10.1021/jf010106t...
|
Ca, Fe e Zn |
Solubilidade, dialisabilidade e célula Caco-2 |
3 FI especiais comerciais |
Pepsina, pancreatina e sal biliar |
AAS |
Judprasong et al., 2005Judprasong, K., Ornthai, M., Siripinyanond, A., & Shiowatana, J. (2005). A continuous-flow dialysis system with inductively coupled plasma optical emission spectrometry for in vitro estimation of bioavailability. Journal of Analytical Atomic Spectrometry, 20(11), 1191. http://dx.doi.org/10.1039/b508639f http://dx.doi.org/10.1039/b508639f...
|
Ca, Fe, Mg, P e Zn |
Diálise em fluxo contínuo (método CFD) |
Matriz variada; material de referência certificado FI |
Pepsina, pancreatina e sal biliar |
ICP OES |
Laparra, Barberá, & Farré, 2005Laparra, J. M., Barberá, R., & Farré, R. (2005). Effect of enzyme amounts used in gastrointestinal digestion upon solubility and caco-2 cell uptake assays of minerals from infant formulas. Food Science and Technology International, 11(6), 425-431. http://dx.doi.org/10.1177/1082013205060195 http://dx.doi.org/10.1177/10820132050601...
|
Ca, Fe e Zn |
Solubilidade e célula Caco-2 |
FI adaptada em laboratório |
Pepsina, pancreatina e sal biliar |
AAS |
Peña et al., 2004Peña, E., Domínguez, R., Bermejo, A., Cocho, J. A., Fraga, J. M., & Bermejo, P. (2004). Enzymolysis approach to compare Cu availability from human milk and infant formulas. Journal of Agricultural and Food Chemistry, 52(15), 4887-4892. PMid:15264930. http://dx.doi.org/10.1021/jf030781y http://dx.doi.org/10.1021/jf030781y...
|
Cu |
Solubilidade |
Leite materno; 1 FI comercial |
Pepsina, pancreatina |
ETAAS |
Perales et al., 2005Perales, S., Barberá, R., Lagarda, M. J., & Farré, R. (2005). Bioavailability of calcium from milk-based formulas and fruit juices containing milk and cereals estimated by in vitro methods (solubility, dialyzability, and uptake and transport by caco-2 cells). Journal of Agricultural and Food Chemistry, 53(9), 3721-3726. PMid:15853426. http://dx.doi.org/10.1021/jf047977y http://dx.doi.org/10.1021/jf047977y...
|
Ca |
Solubilidade, dialisabilidade e célula Caco-2 |
9 tipos refeições, 2 FI adaptadas; 2 FI comerciais |
Pepsina, pancreatina e sal biliar |
AAS |
Perales et al., 2007Perales, S., Barberá, R., Lagarda, M. J., & Farré, R. (2007). Availability of iron from milk-based formulas and fruit juices containing milk and cereals estimated by in vitro methods (solubility, dialysability) and uptake and transport by caco-2 cells. Food Chemistry, 102(4), 1296-1303. http://dx.doi.org/10.1016/j.foodchem.2006.07.019 http://dx.doi.org/10.1016/j.foodchem.200...
|
Fe |
Solubilidade, dialisabilidade e célula Caco-2 |
Amostras modificadas em laboratório |
Pepsina, pancreatina e sal biliar |
AAS |
Roig et al., 1999Roig, M. J., Alegría, A., Barberá, R., Farré, R., & Lagarda, M. J. (1999). Calcium bioavailability in human milk, cow milk and infant formulas: Comparison between dialysis and solubility methods. Food Chemistry, 65(3), 353-357. http://dx.doi.org/10.1016/S0308-8146(98)00232-5 http://dx.doi.org/10.1016/S0308-8146(98)...
|
Ca |
Solubilidade e dialisabilidade |
Leite materno; leite de vaca integral, 2 FI comerciais |
Pepsina, pancreatina e sal biliar |
AAS |
Sarriá & Vaqueiro, 2001 |
Fe e Zn |
Solubilidade e dialisabilidade |
FI comercial em pó e liquida |
Pepsina, pancreatina e sal biliar |
AAS |