Ameziane et al. (1010. Ameziane N, Beillat T, Verpillat P, Chollet-Martin S, Aumont MC, Seknadji P, et al. Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 2003; 23: e61–e64, doi: 10.1161/01.ATV.0000101191.92392.1D. https://doi.org/10.1161/01.ATV.000010119...
) |
2003 |
France |
Age and sex |
MI/UA |
Healthy subjects |
183/216 |
TaqMan |
Balistreri et al. (1111. Balistreri CR, Candore G, Colonna-Romano G, Lio D, Caruso M, Hoffmann E, et al. Role of Toll-like receptor 4 in acute myocardial infarction and longevity. JAMA 2004; 292: 2339–2340.) |
2004 |
Italy |
Age |
MI |
Healthy subjects |
105/127 |
AS-PCR |
Berg et al. (1212. Berg KK, Madsen HO, Garred P, Wiseth R, Gunnes S, Videm V. The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease. Scand J Immunol 2009; 69: 36–42, doi: 10.1111/j.1365-3083.2008.02187.x. https://doi.org/10.1111/j.1365-3083.2008...
) |
2009 |
Norway |
– |
CHD |
CHD-free subjects |
130/100 |
PCR-RFLP |
Boekholdt et al. (1313. Boekholdt SM, Agema WR, Peters RJ, Zwinderman AH, van der Wall EE, Reitsma PH, et al. Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Circulation 2003; 107: 2416–2421, doi: 10.1161/01.CIR.0000068311.40161.28. https://doi.org/10.1161/01.CIR.000006831...
) |
2003 |
Netherlands |
Age |
MI |
Non-MI subjects |
312/343 |
AS-PCR |
Džumhur et al. (1414. Džumhur A, Zibar L, Wagner J, Simundić T, Dembić Z, Barbić J. Association studies of gene polymorphisms in toll-like receptors 2 and 4 in Croatian patients with acute myocardial infarction. Scand J Immunol 2012; 75: 517–523, doi: 10.1111/j.1365-3083.2012.02681.x. https://doi.org/10.1111/j.1365-3083.2012...
) |
2012 |
Croatia |
Age and sex |
MI |
Healthy subjects |
119/120 |
TaqMan |
Edfeldt et al. (1515. Edfeldt K, Bennet AM, Eriksson P, Frostegård J, Wiman B, Hamsten A, et al. Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction. Eur Heart J 2004; 25: 1447–1453, doi: 10.1016/j.ehj.2004.05.004. https://doi.org/10.1016/j.ehj.2004.05.00...
) |
2004 |
Sweden |
Age and sex |
MI |
Healthy subjects |
1172/1517 |
TaqMan |
Enquobahrie et al. (1616. Enquobahrie DA, Smith NL, Bis JC, Carty CL, Rice KM, Lumley T, et al. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Am J Cardiol 2008; 101: 1683–1688, doi: 10.1016/j.amjcard.2008.02.052. https://doi.org/10.1016/j.amjcard.2008.0...
) |
2008 |
USA |
Age and sex |
MI |
Non-MI subjects |
848/2682 |
AS-PCR |
Golovkin et al. (1717. Golovkin AS, Ponasenko AV, Khutornaya MV, Kutikhin AG, Salakhov RR, Yuzhalin AE, et al. Association of TLR and TREM-1 gene polymorphisms with risk of coronary artery disease in a Russian population. Gene 2014; 550: 101–109, doi: 10.1016/j.gene.2014.08.022. https://doi.org/10.1016/j.gene.2014.08.0...
) |
2014 |
Russia |
Age and sex |
CHD |
Healthy subjects |
702/300 |
TaqMan |
Guven et al. (1818. Guven M, Ismailoglu Z, Batar B, Unal S, Onaran I, Karadag B, et al. The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery disease. Gene 2015; 558: 99–102, doi: 10.1016/j.gene.2014.12.047. https://doi.org/10.1016/j.gene.2014.12.0...
) |
2015 |
Turkey |
– |
CHD |
CHD-free subjects |
150/150 |
PCR-RFLP |
Hamann et al. (1919. Hamann L, Gomma A, Schröder NW, Stamme C, Glaeser C, Schulz S, et al. A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. J Mol Med 2005; 83: 478–485, doi: 10.1007/s00109-005-0643-7. https://doi.org/10.1007/s00109-005-0643-...
) |
2005 |
UK |
Age and sex |
CHD |
Healthy subjects |
388/189 |
TaqMan |
Hernesniemi et al. (2020. Hernesniemi J, Lehtimäki T, Rontu R, Islam MS, Eklund C, Mikkelsson J, et al. Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions. Scand J Clin Lab Invest 2006; 66: 667–675, doi: 10.1080/00365510600933011. https://doi.org/10.1080/0036551060093301...
) |
2006 |
Finland |
– |
CHD |
CHD-free subjects |
333/299 |
AS-PCR |
Holloway et al. (2121. Holloway JW, Yang IA, Ye S. Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction. Pharmacogenet Genomics 2005; 15: 15–21, doi: 10.1097/01213011-200501000-00003. https://doi.org/10.1097/01213011-2005010...
) |
2005 |
UK |
Age |
MI |
Non-MI subjects |
586/492 |
ARMS-PCR |
Koch et al. (2222. Koch W, Hoppmann P, Pfeufer A, Schömig A, Kastrati A.Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population. Eur Heart J 2006; 27: 2524–2529, doi: 10.1093/eurheartj/ehl231. https://doi.org/10.1093/eurheartj/ehl231...
) |
2006 |
Germany |
– |
MI |
CHD-free subjects |
3657/1211 |
TaqMan |
Kolek et al. (2323. Kolek MJ, Carlquist JF, Muhlestein JB, Whiting BM, Horne BD, Bair TL, et al. Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. Am Heart J 2004; 148: 1034–1040, doi: 10.1016/j.ahj.2004.05.049. https://doi.org/10.1016/j.ahj.2004.05.04...
) |
2004 |
USA |
– |
CHD |
CHD-free subjects |
1375/519 |
TaqMan |
Martinez-Rios et al. (2424. Martínez-Ríos MA, Vargas-Alarcón G, Vallejo M, Cruz-Martínez E, Pérez-Méndez O, Medina-Andrade Á, et al. Toll-like receptor 4 gene polymorphisms and acute coronary syndrome: no association in a Mexican population. Arch Cardiol Mex 2013; 83: 257–262.) |
2013 |
Mexico |
– |
ACS |
Healthy subjects |
457/283 |
TaqMan |
Morange et al. (2525. Morange PE, Tiret L, Saut N, Luc G, Arveiler D, Ferrieres J, et al. TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study. Eur J Hum Genet 2004; 12: 1041–1049, doi: 10.1038/sj.ejhg.5201277. https://doi.org/10.1038/sj.ejhg.5201277...
) |
2004 |
France/Ireland |
Age |
CHD |
CHD-free subjects |
247/490 |
AS-PCR |
Nebel et al. (2626. Nebel A, Flachsbart F, Schäfer A, Nothnagel M, Nikolaus S, Mokhtari NE, et al. Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. Mech Ageing Dev 2007; 128: 409–411, doi: 10.1016/j.mad.2007.04.001. https://doi.org/10.1016/j.mad.2007.04.00...
) |
2007 |
Germany |
Age |
MI |
Healthy subjects |
606/323 |
TaqMan |
O’Halloran et al. (2727. O'Halloran AM, Stanton A, O'Brien E, Shields DC. The impact on coronary artery disease of common polymorphisms known to modulate responses to pathogens. Ann Hum Genet 2006; 70: 934–945, doi: 10.1111/j.1469-1809.2006.00281.x. https://doi.org/10.1111/j.1469-1809.2006...
) |
2006 |
Ireland |
– |
CHD |
Healthy subjects |
1598/386 |
AS-PCR |
Yang et al. (2828. Yang IA, Holloway JW, Ye S, Southampton Atherosclerosis Study (SAS) Group. TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis. Atherosclerosis 2003; 170: 187–190, doi: 10.1016/S0021-9150(03)00286-7. https://doi.org/10.1016/S0021-9150(03)00...
) |
2003 |
UK |
– |
CHD |
CHD-free subjects |
1078/322 |
ARMS-PCR |
Zee et al. (2929. Zee RY, Hegener HH, Gould J, Ridker PM. Toll-like receptor 4 Asp299Gly gene polymorphism and risk of atherothrombosis. Stroke 2005; 36: 154–157, doi: 10.1161/01.STR.0000149948.31879.f0. https://doi.org/10.1161/01.STR.000014994...
) |
2005 |
USA |
Age and smoking |
MI |
CHD-free subjects |
370/695 |
AS-PCR |