(35) 2010 |
BMG (bone matrix gelatin) × autogenous bone graft |
- |
- |
Freeze-drying |
Study in cats with alveolar osseous defects (n=4). |
Greater levels of new formed bone in BMG group. Only on day 56, the mean of bone density was significantly higher in the BMG group. |
(36) 2011 |
β-TCP |
- |
Platelet-derived growth factor (PDGF) |
- |
Clinical trial, periodontal osseous defects (n=27). |
The linear bone growth and percentage of bone filling were significantly higher in the PDGF+β-TCP group at 6 months compared with that in the β-TCP group. |
(37) 2012 |
β-TCP |
- |
BMP-7 |
- |
Study in rabbits with osseo-periosteal mandibular defect (n=6). |
The overall mean of the percentage of regenerated bone was considerably greater when BMP-7 was incorporated. |
(38) 2013 |
PCL/TCP (80:20) (Osteopore) |
BMSC |
- |
3D printing |
Vertical alveolar ridge defect in dogs' mandible (n=4). |
Early revascularization and higher amount of new bone. |
(39) 2015 |
β-TCP and Type I collagen |
BMSC |
- |
- |
Study in beagle dogs with class III furcation defects (n=6). |
BMSC/collagen and BMSC/collagen/β-TCP enhanced periodontal tissue regeneration compared with collagen and β-CP/collagen. |
(40) 2015 |
Magnesium/PLGA |
- |
- |
Solvent casting, salt leaching |
Study in beagle dogs with alveolar bone defects (n=6). |
Mg provided pH buffering properties to the scaffold, as well as an osteoconductive environment for bone growth. |
(41) 2016 |
Chitosan/β-glycerophosphate with anorganic bovine bone |
BMSC |
- |
Freeze-drying |
Study in beagle dogs with bone periodontal defects (n=6). |
Highest new bone area value and new bone height value compared with the control group. No significant difference was shown with the incorporation of the cells. |
(42) 2017 |
Fibronectin/decellularized pulp tissue |
- |
- |
Decellularization and freeze-drying |
Study in rabbits with calvaria defects (n = 12). |
Silk fibroin-coated scaffold demonstrated the ability to induce new bone formation with low inflammation and high vascularity. |
(43) 2018 |
Nano-HA and collagen type I (1:1)(Allgens)+Mg-Ca alloy rods |
- |
- |
Three Mg-Ca alloy rods were insertedinto mineralized collagen |
Study in dogs with canine socket preservation model (n=6). |
The combined scaffold of mineralized collagen/ Mg-Ca alloy rods was more effective at reducing the absorption of the alveolar ridge and preserving the socket site than the mineralized collagen alone. |
(44) 2019 |
Silica coated nanoHA-gelatin reinforced and poly(L-lactic acid) PLLA |
- |
- |
Electrospun and chemical synthesis route |
Study in rabbits with bone defects in the jaw (n=12). |
The scaffold suffered degradation along with the regeneration of new tissue. |
(45) 2020 |
PCL/TCP-based ink and methacrylate hyaluronic acid/methacrylate gelatin-based bioink |
- |
Resveratrol and strontium ranelate |
3D printing |
Study in rats with critical-sized mandibular bone defect (n=6). |
Enhanced angiogenesis and inhibition of osteoclast activity. The scaffolds promoted MSC osteogenic differentiation and bone formation |