Dear Editor,
We would like to share ideas on the publication “The risk of nonsyndromic cleft lip with or without cleft palate and Vax1 rs7078160 polymorphisms in southern Han Chinese”.11 Wang Q, Sun S, Song Q, Hu H, An J, Liu J. The risk of nonsyndromic cleft lip with or without cleft palate and Vax1 rs7078160 polymorphisms in southern Han Chinese. Braz J Otorhinolaryngol. 2021;87:718-22. Wang et al. noted that “rs7078160 polymorphism is a risk factor of non-syndromic cleft lip with or without cleft palate, and Vax1 is strongly associated with non-syndromic cleft lip with or without cleft palate in Southern Chinese Han populations”.11 Wang Q, Sun S, Song Q, Hu H, An J, Liu J. The risk of nonsyndromic cleft lip with or without cleft palate and Vax1 rs7078160 polymorphisms in southern Han Chinese. Braz J Otorhinolaryngol. 2021;87:718-22. We concur that the present study might support that the Vax1 rs7078160 polymorphisms might relate to nonsyndromic cleft lip. Nevertheless, there are other genetic polymorphisms that might have clinical relationship. The examples of those polymorphisms are ABCA4, IRF6 and MTHFD1 gene polymorphisms.11 Wang Q, Sun S, Song Q, Hu H, An J, Liu J. The risk of nonsyndromic cleft lip with or without cleft palate and Vax1 rs7078160 polymorphisms in southern Han Chinese. Braz J Otorhinolaryngol. 2021;87:718-22.
2 Zhang S, Chen Q, Yang C, Shi J, Lin Y, Duan S, et al. Association between variants around IRF6 and non-syndromic orofacial cleft in Western Han Chinese. Oral Dis. 2021;(Dec), http://dx.doi.org/10.1111/odi.14100. Online ahead of print.
http://dx.doi.org/10.1111/odi.14100....
3 Purohit MR, Saikrishna L, Verma H, Bhaskar LVKS, Hussain SA. Association Between MTHFD1 1958G & A Variant and non-Syndromic Cleft lip and Palate: An Updated Meta-Analysis. Cleft Palate Craniofac J. 2021;(Dec):10556656211046486, http://dx.doi.org/10.1177/10556656211046486. Online ahead of print.
http://dx.doi.org/10.1177/10556656211046...
-44 Zawiślak A, Woźniak K, Agirre X, Gupta S, Kawala B, Znamirowska-Bajowska A, et al. Association of ABCA4 Gene Polymorphisms with Cleft Lip with or without Cleft Palate in the Polish Population. Int J Environ Res Public Health. 2021;18:11483. If there is a concurrent of those mentioned polymorphisms, there might be a confounding effect of the present study by Wang et al. Further studies might be conducted in order to assess possible confounding effect from those genetic polymorphisms.
References
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1Wang Q, Sun S, Song Q, Hu H, An J, Liu J. The risk of nonsyndromic cleft lip with or without cleft palate and Vax1 rs7078160 polymorphisms in southern Han Chinese. Braz J Otorhinolaryngol. 2021;87:718-22.
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2Zhang S, Chen Q, Yang C, Shi J, Lin Y, Duan S, et al. Association between variants around IRF6 and non-syndromic orofacial cleft in Western Han Chinese. Oral Dis. 2021;(Dec), http://dx.doi.org/10.1111/odi.14100. Online ahead of print.
» http://dx.doi.org/10.1111/odi.14100 -
3Purohit MR, Saikrishna L, Verma H, Bhaskar LVKS, Hussain SA. Association Between MTHFD1 1958G & A Variant and non-Syndromic Cleft lip and Palate: An Updated Meta-Analysis. Cleft Palate Craniofac J. 2021;(Dec):10556656211046486, http://dx.doi.org/10.1177/10556656211046486. Online ahead of print.
» http://dx.doi.org/10.1177/10556656211046486 -
4Zawiślak A, Woźniak K, Agirre X, Gupta S, Kawala B, Znamirowska-Bajowska A, et al. Association of ABCA4 Gene Polymorphisms with Cleft Lip with or without Cleft Palate in the Polish Population. Int J Environ Res Public Health. 2021;18:11483.
Publication Dates
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Publication in this collection
27 June 2022 -
Date of issue
May-Jun 2022
History
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Received
07 Jan 2022 -
Accepted
13 Jan 2022
