DeAngelis et al. (Australia, 2011)3
|
24 (7 M/17 F), mean age of 58 years (range 30–81 years). |
The palate was the most often affected site, representing 37.5% of
cases. |
4.1% had metastases to the cervical lymph nodes and 4.1%, to the
cervical spine. |
Surgery was performed in 91.6% patients; 87.5% of cases were associated
with radiotherapy. Neck dissection was performed in 20.8% of cases. |
25% of the patients had recurrence. |
Chen AM et al. (USA, 2006)7
|
140 (81 M/59 F), mean age of 57 years (range 11–91 years). |
Parotid (14%); submandibular (18%); sublingual (7%); lacrimal gland
(2%); minor salivary glands (24%); oropharynx (9%); hypopharynx (4%);
paranasal sinuses (20%); trachea (3%). |
25% of patients had distant metastases. |
All patients were treated with definitive surgery. |
16.4% had recurrence. |
Min et al. (China, 2012)9
|
616 (302 M/314 F), mean age of 51.6 years (range 11–89 years). |
Parotid gland (11%); submandibular gland (13%); sublingual gland (7.5%);
hard/soft palate (26.9%); maxillary sinus (9.7%); tongue ventral surface
(2.8%); tongue dorsal surface (8.4%); mouth floor (9.6%); oral mucosa
(5%); others (6%). |
10.06% of cases had metastases to cervical lymph nodes. |
Surgical treatment followed by postoperative radiotherapy was the main
option. |
Not reported. |
Luksi et al. (Croatia, 2013)10
|
26 (12 M/14 F), mean age of 58 (range 34–88) years. |
Palate (62%); mouth floor (15%); alveolar mucosa (12%); upper lip (8%);
jugal mucosa (4%). |
46.1% had distant metastases. |
Surgical treatment followed by postoperative radiotherapy was the main
option. |
26.9% had recurrence. |
Tincani et al. (Brazil, 2006)11
|
21 (7 M/14 F), aged 26–72 years. |
Parotid (19%); submandibular gland (33.3%); palate (47.6%). |
33.3% had regional metastases and 22.2% had distant metastasis. |
Surgery was the main treatment with adjuvant radiation therapy in many
cases, whereas resection of the structure was necessary in other
cases. |
38.09% had recurrence. |
Bianchi et al. (Italy, 2008)12
|
67 (28 M/39 F), mean age of 54.5 years (range 28–84 years). |
Palate (71.6%); lips (3%); alveolar mucosa (1.5); jugal mucosa (4.5%);
retromolar region (4.5%); tongue (4.5%); mouth floor (9%); others
(1.5%). |
29.8% of patients had distant metastases. |
All patients were treated with surgery as the primary modality.
Dissection was performed in 9% of patients, and over half (59.7%) were
treated with adjuvant radiation therapy. |
29.8% of patients had recurrence. |
Perez et al. (Brazil, 2005)13
|
129 (71 M/58 F), mean age of 51.5 years (range 10–96 years). |
Palate (22.5%); tongue (7.7%); jugal mucosa (3.9%); mouth floor (3.9%);
upper lip (3.1%); lower lip (0.8%); parotid (19.4%); submandibular
(15.5%); sublingual (2.3%); others (20.9%). |
10.07% had regional metastases and 8.5% had distant metastasis. |
Patients were treated with local resection associated with postoperative
radiotherapy (42.7%), local resection alone (30.2%), or radiotherapy
alone (10.1%). Other therapeutic modalities included radiotherapy and
chemotherapy (3.9%), local resection and chemotherapy (2.3%), and
chemotherapy alone (1.5%). 9.3% of patients received only supportive
care. |
55% had local recurrence. |
Khan et al. (USA, 2001)14
|
68 (3 0 M/38 F), mean age at diagnosis of 52 years. |
The most affected sites were the oropharynx (23.5%), parotid (22.05%),
submandibular gland (16.17%). |
10.2% had pulmonary metastasis and 5.8% had lymph node metastasis. |
The primary treatment was surgery. 8.8% of patients underwent radiation,
7.3% of patients were poor surgical candidates due to comorbidities, and
were treated with curative intent, while 1.4% of patients were treated
with palliative care. |
42.6% had recurrence. |
Sung et al. (Korea, 2003)15
|
94 (44 M/50 F), age of 44.5 years (range 20–78 years). |
The most affected sites were the minor salivary glands (69.1%) and the
major salivary glands (30.8%). |
26.5% of patients had distant metastases and 3.1% had regional
metastasis. |
In cases of patients with distant metastases, 10.6% were treated with
surgery, 8.5% with radiotherapy, and 29.7% with both. In patients without
distant metastasis, 6.3% were treated with surgery, 7.4% with
radiotherapy, and 37.2% with both. |
18.08% had recurrence. |