The impact of gender, age and hearing loss on tinnitus severity

Summary Tinnitus is a symptom present in approximately 15% of the world population. Most patients are between 40 and 80 years of age; the prevalence above 60 reaches 33%. About 20% have moderate to severe impact in the quality of life but the factors associated with the tinnitus annoyance are not completely known. Aim The objective of this study is to evaluate the relationship between age, gender and hearing loss on tinnitus annoyance. Materials and methods 68 patients were evaluated at the tinnitus center at our hospital, from March 2007 to march 2008, with a detailed interview, complete otolaryngological examination, the Portuguese version of the Tinnitus Handicap Inventory and pure tone audiometry. Results Age varied from 24 to 83 (mean=59); the mean THI value was 39 (females: 36; males: 44). THI grades were: slight: 32.3%; mild: 19.1%; moderate: 20.6%; severe: 13.2% and catastrophic: 14.7%. No significant correlation was found between gender (p=0.30), age (p=0.77) hearing loss (p>0.05 for all averages analyzed) and tinnitus severity. Conclusion Gender, age and hearing loss do not influence tinnitus annoyance, using the THI.


INTRODUCTION
Tinnitus is defined as the perception of sound in the ears or head with no external source of sound. It affects about 15% of the world population; 1 this prevalence increases to 33% in individuals aged over 60 years. 2 About 20% of patients with tinnitus find the symptoms difficult to bear, which significantly affects their quality of life. Several studies have attempted to investigate the causative factors of tinnitus. [3][4][5][6][7][8][9][10][11][12][13][14] Some have shown that the limitations due to tinnitus depend on primary psychological factors, such as difficulties in dealing with the problem, 8,12,[15][16][17] altered humor (depression and anxiety), low concentration, irritability, loss of control, 18 and a variety of psychiatric conditions and specific personality traits. 12,[15][16][17]19 Contrary to what was commonly thought, Jastreboff and Hazell 2 demonstrated that there are no psychoacoustic differences of tinnitus (intensity, frequency and minimum suppression level) among patients with tinnitus that suffer and those that do not. Other authors, however, have shown a small correlation between the intensity of tinnitus and its effect on patients. [19][20][21] Thus, in medical practice, it is important to differentiate the intensity of tinnitus and how annoying it is for patients, since these parameters appear to correlate poorly. 11 The influence of hearing loss on the degree of suffering caused by tinnitus remains uncertain. 22 Weisz 23 showed that severe tinnitus was associated with hearing loss for high frequencies. McKinney et al. 24 found that clinically important hearing loss in tinnitus patients were associated with anxiety and depression as a reaction to hearing loss, which could affect the impact of tinnitus. It is thus still uncertain whether hearing loss is only a trigger for the onset of tinnitus or if it also predicts its severity and handicap. 24,25 Searchfield et al. 13 showed that low frequency hearing loss was correlated with increased annoyance due to tinnitus as assessed in the Tinnitus Handicap Questionnaire (THQ); the highest scores, however, were given to questions on hearing, rather than the total THQ score. In this same study, the Tinnitus Severity Index (TSI) -a questionnaire assessing how bothersome tinnitus is -did not correlate with any audiometric findings. Such poor correlation suggests that tinnitus patients are heterogeneous, and that several factors affect the impact of this symptom on the quality of life.
The prevalence of hearing loss and tinnitus increases with age. 3,26 However, Meric et al. 7 applied different questionnaires for evaluating the impact of tinnitus on quality of life, and found no correlation between age, sex or duration of tinnitus with the annoyance it generated. Davis 27 and Coelho et al. (2004) 1 found that female patients gave significantly higher annoyance scores compared to males. On the other hand, Hiller and Goebel 11 encountered a higher severity (intensity and annoyance) due to tinnitus in older male patients.
Because of the subjective nature of tinnitus, its diversity of causes, and the heterogeneity of patients, this symptom is a complex topic to study and understand. Given such controversies, the purpose of this paper was to assess the influence of sex, age and degree of hearing loss on the annoyance patients felt due to tinnitus.

MATERIAL AND METHOD
The institutional review board of our institution approved this study design and the free informed consent form (number 097/07), which met all the requirements for clinical studies on human beings.
There were 68 patients seen consecutively at the tinnitus outpatient unit of our institution from March 2007 to March 2008.
Inclusion criteria were as follows: 1. Age from 18 to 85 years. 2. Presence of unilateral or bilateral tinnitus lasting over 3 months. 3. Ability to answer the proposed questions. 4. Pure tone audiometry showing sensorineural dysacusis of any degree.
An acute or chronic infection of the external or middle ear was an exclusion criterion.
All patients were evaluated with the same systematic protocol for tinnitus patients and sound intolerance developed by Sanchez. This protocol was the basis for selecting the epidemiological and clinical data and the features of tinnitus and correlated symptoms for this study.
These means were ipsilateral to tinnitus in patients with unilateral tinnitus, and ipsilateral to the side with worst tinnitus in patients with asymmetric bilateral tinnitus. The side with the worst tone means was used in symmetrical cases.
The Statistical Analysis System (SAS) software, version 9.1, was used for statistical calculations. The statistical tests included Wilcoxon's rank sum test and the Kruskal-Wallis non-parametric test for differences between means to correlate sex and the THI. Pearson's coefficient yielded the p values associated with the test statistics for numerical correlations (age, different means calculated based on pure tone audiometry and the THI).
Age ranged from 24 to 83 years (mean -59 years). The mean age among females was 61 years and the mean age among males was 57 years. Table 1 shows the standard deviation and variation coefficients. There were no statistically significant differences between the mean ages of both sexes (p=0.30). Table 2 shows the final mean of the THI results according to each sex and the standard deviation and variation coefficient. There were no statistically significant differences in the THI scores according to sex according to the Kruskal-Wallis test (p=0.30), shown on Table 2.
The Wilcoxon rank-sum test revealed no statistically significant correlation (p value 0.30) between sex and the annoyance of tinnitus.
Pearson's correlation coefficient revealed no statistically significant correlation (Pearson's coefficient -0.03 and p value 0.77); it was not possible to predict the severity of tinnitus based on the patient's age.
Chart 2 shows the THI scores in different age groups. There were 7 patients (10%) under age 45 years, 39 patients (57%) aged from 45 to 65 years, and 22 patients (32%) aged over 65 years. The correlation of means in pure tone audiometry and the THI were: a) Conventional tritone mean -mean tri (500, 1000, 2000Hz): There was no statistically significant correlation between the conventional tritone mean and the THI score (Pearson's correlation coefficient: 0.122 and p value: 0.32).

DISCUSSION
Patients complaining of tinnitus may present varying degrees of annoyance with this symptom, with variable impact on the quality of life. Two important factors associated with tinnitus should be differentiated: the intensity of the tinnitus signal and the severity of this symptom or the annoyance that it causes to the lives of patients.
Studies have been controversial on the effect of gender on the prevalence of tinnitus. Although some have described a slightly higher prevalence in females, 30,31 others have suggested that the prevalence is higher in males; 19,32 these studies rarely have statistical significance. A possible explanation for a higher prevalence in males may be that men are more exposed to occupational noise. 33 Women, on the other hand, generally have more time to seek medical care, which may explain a higher prevalence in females.1 Women also predominated in our study.
Based on the final THI score, we found no difference in the annoyance due to tinnitus among males and females. These findings concur with those of Erlandsson and Holgers 9 even though these author applied another questionnaire, the Tinnitus Severity Questionnaire (TSQ) which assesses the severity of tinnitus, quality of life issues, concentration difficulties, discomfort in silence, and depressive reactions. Our findings also concur with A possible indirect influence of sex is depression. Dobie and Sullivan 35 estimated the prevalence of major depression in the adult population at 5%, which increases to 10% in patients receiving any type of medical care. These authors estimated that the incidence of major depression during life was double in females (20%) compared to males (10%). As the severity of tinnitus is strongly correlated with the presence of depression, it may be assumed that bothersome tinnitus occurs more often in females, as Davis 34 suggests, even though this was not evident in our study. Most studies have shown that the limitations (and even disability) generated by tinnitus depend to a large extent on primary psychological factors, such as difficulty in dealing with this problem. 8,12,[15][16][17] There is a strong correlation between the severity of tinnitus and altered humor (depression and anxiety), poor concentration, irritability, and loss of control. 15 Most studies suggest fairly clearly a relation between the severity of annoyance due to tinnitus and the presence of psychiatric conditions and specific personality traits. 12,[15][16][17]19 Hiller and Goebel (2006) 11 found significant severity in terms of intensity and annoyance due to tinnitus in older male patients with binaural tinnitus and vertigo, hearing loss and hyperacusis, again contradicting our findings. The mini Tinnitus Questionnaire (mini-TQ) was used for assessing annoyance.
The prevalence of hearing loss and tinnitus increases with age, regardless of any history of occupation noise exposure. According to the National Hearing Study, 3 there is a trend for increasing bothersome tinnitus with age.
We found no correlation between bothersome tinnitus and age in our sample. Chart 2 shows an apparent increase of the THI scores in the 45 to 65 age group; however, this is due only to a larger number of patients with this age in our study.
Our findings, as mentioned above, concur with those of Meric et al. 7 in that no correlation was found between age and annoyance generated by tinnitus, based on the THQ, TRQ and STSS questionnaires. Hiller and Goebel 11 on the other hand, found increased annoyance in older patients, which diverges from our findings.
Of note is the influence, attention and silence on the perception and annoyance due to tinnitus. Studies by Heller and Bergman 36 and Knobel and Sanchez 37 have suggested that tinnitus is a common subaudible phenomenon that may be perceived in silent ambiences or during heightened auditory perception. 37 Thus, it may be inferred that older patients, having less work, remain longer in their homes, where silence and auditory attention could possibly be more relevant for increasing the perception of annoyance due to tinnitus. Brown 26 found that subjects who do not work tend to present more tinnitus, but did not comment on this association. In Brazil there are many retired persons who continue to work on regular jobs. Surveys done by the Legislative Advisory Group of the House of Representatives 38 and the Applied Economic Survey Institute (IPEA) 39 have shown a high participation of retired elderly Brazilians in the labor market. Over half of elderly males and nearly one third of elderly females in the labor market had been retired, and that this tends to increase. In 2003, 46% of older men were working in regular jobs. The percentage of working women aged at least 60 years reached 19.6% in Brazil; only Nordic countries have higher percentages. This may explain why we found no correlation between age and bothersome tinnitus in our sample, since many elderly persons continue to work.
Tinnitus has been associated with almost all ear abnormalities, particularly with cochlear conditions. 40 Hearing loss -especially severe loss -may be an added handicap to tinnitus, generating additional discomfort to patients; rather than affecting tinnitus directly, this adds to the general health problems that patients face.
We found no correlation between the severity of tinnitus and the degree of hearing loss. Holgers 19 however, has shown a moderate association between the severity of tinnitus and audiometric parameters, such as the tritone mean. 19 Axelsson and Ringdahl 30 concluded that tinnitus is more common and severe in patients with hearing loss, which diverges from our findings. Coles 3 showed that the severity of tinnitus was correlated with auditory difficulty, finding mild hearing loss in patients with tinnitus that were mildly bothered and severe or profound hearing loss in patients with severely bothersome tinnitus, again diverging from our findings. This study also found that the chance of having moderately to severely bothersome tinnitus increased hand in hand with auditory thresholds at high frequencies.
Weisz 23 showed that increased hearing loss at high frequencies were associated with a lower severity of tinnitus.
Holgers 8 found that absence from work due to tinnitus were more frequent in patients with higher degrees of hearing loss. We may infer that these patients are more bothered with tinnitus, justifying their absence of work by associating annoyance with worse hearing.
Baskill and Coles 22 have suggested that the influence of hearing loss on the severity of tinnitus remains uncertain; these authors found that auditory thresholds and bothersome tinnitus were poorly correlated, which is similar to our findings. Savastano 14 evaluated the relation between the THI score and the presence or absence of hearing loss in patients with tinnitus. THI results revealed that, in most cases, a slight or mild groups in the THI was attributed to individuals with hearing loss; normal hearing patients with tinnitus were more frequent in the moderate and catastrophic groups, which was statistically significant compared to the hearing loss group. Savastano 14 used the same tool for evaluating bothersome tinnitus that we applied in our study (THI) and found that more severe hearing loss did not correlate with the severity of bothersome tinnitus, similar to our findings.
Sanchez et al. 41 monitored tinnitus patients with normal pure tone audiometries and found that within a mean time of 3.5 years, 44.6% progressed with hearing loss, and that the majority of subjects in this group reported no change or improvement of tinnitus during this period. This finding may represent natural habituation with tinnitus in these patients.
Hallberg and Erlandsson 42 found worse auditory thresholds in patients that reported more concentration difficulties and sleep disorders due to tinnitus, compared with patients with no complaints of tinnitus; these authors found that bothersome tinnitus was not more severe in patients with more severe hearing loss, again similar to our findings.
McKinney, Hazell and Graham 24 found that more severe hearing loss in patients with tinnitus was associated with more frequent depression and anxiety, which could affect the impact of tinnitus on their quality of life. For many authors, it is not certain whether hearing loss is only a trigger for the onset of tinnitus or whether is also affects the severity and limitations of this symptom. 22,24,25 Meric et al. 7 found that tinnitus had more impact if there was associated hearing loss; patients without hearing loss appeared to have less bothersome tinnitus, which diverges from our results.
Searchfield et al. 13 correlated the TSI and the THQ with hearing loss as assessed with pure tone audiometry, and found that hearing loss at low frequencies correlated with more severe bothersome tinnitus when evaluated by the THQ; significance was found only in the part of the questionnaire that contains questions on hearing, and not in the total score. The TSI did not correlate with any aspect of audiometry. The TSI is a shorter questionnaire that does not correlate with hearing loss; it only evaluated the degree of bothersome tinnitus. The correlation between hearing loss and the level of annoyance with tinnitus was poor in that study, which concurs with our findings.
We noted that findings in several studies vary widely, reflecting the idea that tinnitus patients are a heterogeneous group, and that many factors determine the impact of tinnitus on the lives of patients.

CONCLUSION
According to the tool applied in this study, we concluded that the sex and age of patients, and the degree of hearing loss, have no influence on the annoyance generated by tinnitus in each patient.