Use of etoricoxib and dexamethasone for postoperative pain prevention and control in mucogingival surgery: a randomized parallel double-blind clinical trial

Ligia Nadal Zardo Fábio André dos Santos Gibson Luiz Pilatti About the authors

Abstract

AIM: To compare the use of etoricoxib and dexamethasone for postoperative pain prevention and control after mucogingival surgery. METHODS: Fifty-eight patients with indication for mucogingival surgery took part in this randomized parallel double-blind clinical trial. They were divided into three groups (G): G1 - placebo 1 h before surgery; G2 - 8 mg dexamethasone 1 h before surgery; G3 - 90 mg etoricoxib 1 h before surgery. Pain intensity was assessed in donor and recipient sites separately using the 101-point numerical rating scale NRS - 101, every hour for the first 8 h after surgery and three times a day on the following 3 days. RESULTS: there was a statistically significant difference in the postoperative pain intensity in the donor site between G1 and G3 after 1 h, 2 h, 3 h, 7 h, 8 h and on the second day - in the evening after 32 h; between G1 and G2 after 2 h and 3 h, and between G2 and G3 only after the first hour. Pain intensity in the recipient site was statistically significant between G1 and G3 after 1 and 2 h (p<0.05). In addition, there was a lower ingestion of rescue medication in G2 and in G3 than in G1 (p=0.002). CONCLUSIONS: the use of a pre-emptive single dose of etoricoxib or dexamethasone may be considered an effective protocol for postoperative pain prevention and control after mucogingival surgery.

analgesia; pain, postoperative; surgery, oral


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Publication Dates

  • Publication in this collection
    31 Jan 2014
  • Date of issue
    Dec 2013

History

  • Received
    12 Aug 2013
  • Accepted
    17 Dec 2013
Faculdade de Odontologia de Piracicaba - UNICAMP Avenida Limeira, 901, cep: 13414-903, Piracicaba - São Paulo / Brasil, Tel: +55 (19) 2106-5200 - Piracicaba - SP - Brazil
E-mail: brjorals@unicamp.br