Prevalence of persistent pain after endodontic treatment: a systematic review and meta-analysis

Martins, Edmundo Duarte; Borges, Allya Francisca Marques; Leão, Lidiane Oliveira; Araujo, Bianca Marques de Mattos de; Stechman Neto, José; Kowaltschuk, Tatiana Carvalho; Corrêa, Camila de Castro; Araújo, Cristiano Miranda de; Taveira, Karinna Veríssimo Meira

doi:10.20396/bjos.v25i00.8679272

person Edmundo Duarte Martins

Conceptualization · Formal analysis · Data curation · Writing – Original Draft · actively revised and approved the final version of the manuscript

schoolDepartment of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

0009-0005-7784-429X

person Allya Francisca Marques Borges

Data curation · actively revised and approved the final version of the manuscript

school Department of Speech-Language Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

0000-0003-0967-4899

person Lidiane Oliveira Leão

Conceptualization · Formal analysis · Data curation · Investigation · Writing – Original Draft · actively revised and approved the final version of the manuscript

schoolDepartment of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

0009-0007-3965-0851

person Bianca Marques de Mattos de Araujo

Investigation · Writing – Original Draft · Visualization · actively revised and approved the final version of the manuscript

schoolDepartment of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.

0000-0002-7507-4667

person José Stechman Neto

Investigation · Supervision · actively revised and approved the final version of the manuscript

schoolDepartment of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.

0000-0002-0259-2420

person Tatiana Carvalho Kowaltschuk

Investigation · Writing – Original Draft · Visualization · actively revised and approved the final version of the manuscript

schoolDepartment of Endodontics, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.

0000-0002-9060-6852

person Camila de Castro Corrêa

Investigation · Writing – Original Draft · actively revised and approved the final version of the manuscript

school Department of Speech-Language Pathology, University Vale do Rio Doce, Governador Valadares, Minas Gerais, Brazil.

0000-0001-5460-3120

person Cristiano Miranda de Araújo

Investigation · Supervision · Writing – Original Draft · Visualization · actively revised and approved the final version of the manuscript

schoolDepartment of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.

0000-0003-1325-4248

person Karinna Veríssimo Meira Taveira

Conceptualization · Methodology · Validation · Formal analysis · Investigation · Resources · Data curation · Writing – Review & Editing · Visualization · Supervision · Project administration · actively revised and approved the final version of the manuscript

schoolDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

0000-0001-6978-4083

personCorresponding author: Karinna Veríssimo Meira Taveira Federal University of Rio Grande do Norte – UFRN Department of Morphology – Center of Biosciences BR 101- Lagoa Nova - Natal, Rio Grande do Norte, Brazil Zip code: 59072-970 Phone: +55 (84) 3215-3431 E-mail:
karinna.taveira@ufrn.br

Editor:

Dr. Altair A. Del Bel Cury

Conflict of Interest:

The authors declare that they have no conflict of interest.

Author, year	Reason for exclusion
Wright²⁴, 2000	2
Alonso and Nixdorf²⁵, 2006	2
Baad-Hansen²⁶, 2008	4
Israel et al.²⁷, 2003	2
Linn et al.²⁸, 2007	2
Ferreira et al.²⁹, 2020	2
Machado et al.³⁰, 2022	2
Pigg et al.³¹, 2013	2
Renton³², 2019	2
Sjögren et al.³³, 2019	3
Arias et al.³⁴, 2013	2
Macrae³⁵, 2008	2
Battrum et al.³⁶, 1996	2
Pasqualini et al.³⁷, 2012	2
Nasri-Heir et al.¹⁷, 2015	2

Author, years, country	Sample size and (sex)	Mean ages	Endodontic Procedure	Teeth Enrolled	Follow-up n (%)	Non-odontogenic tooth pain	Follow-up (y)	Study type
Abbott¹⁴, 1994, Australia	100 26 (men) 74 (women)	39.3 years	Nonsurgical root canal therapy	110	110	110	NR	Cross- sectional
Daline et al.⁹, 2020, United States	NR	NR	Initial nonsurgical root canal therapy	45	45 (100)	45	3,4	Cohort
Danin et al.³⁸, 1999, Sweden	10 4 (men) 6 (women)	55 years	Periapical Surgery	50	43 (86)	1	1-1	Cohort
de Chevigny et al.³⁹, 2008, Canada	137 63 (men) 74 (women)	NR	Initial nonsurgical root canal therapy	582	137 (24)	6	4-6	Cross-sectional
de Chevigny et al.², 2008, Canada	126 40 (men) 86 (women)	NR	Retreatment nonsurgical root canal therapy	477	122 (26)	6	4-6	Cross-sectional
Erdogan et al.⁷, 2022, United States	35 7 (men) 28 (women)	48 years	Review of eletronic dental records	60	35 (83)	29	3,6	Cross-sectional
Farzaneh et al.⁴⁰, 2004, Canada	103 40 (men) 63 (women)	NR	Initial nonsurgical root canal therapy	523	103 (20)	0	4-6	Cohort
Farzaneh et al.⁴¹, 2004, Canada	122 65 (men) 57 (women)	NR	Initial nonsurgical root canal therapy	422	122 (28)	3	4-6	Cohort
Klasser et al.¹⁵, 2011, United States	18 9 (men) 9 (women)	50.6 years	Initial nonsurgical root canal therapy	250	18 (7)	18	3m-4y	Cross-sectional
Lobb et al.⁴², 1996, United States	NR	NR	Initial nonsurgical root canal therapy	165	36 (21,8)	36	1	Cross-sectional
Marquis et al.⁵, 2006, Canada	132 54 (men) 78 (women)	21% patients with even 45 years; 77% over to 45 years	Initial nonsurgical root canal therapy	532	132 (25)	7	4-4	Cohort
Nixdorf et al.⁴³, 2015, United States	19 3 (men) 16 (women)	49 years	Initial nonsurgical root canal therapy	651	65 (10)	65	6-6	Cohort
Oshima et al.⁸, 2009, Japan	16 3 (men) 13 (women)	46.8 years	Initial nonsurgical root canal therapy	271	16 (5.9)	16	9,8 m	Cross-sectional
Polycarpou et al.⁴⁴, 2005, United Kingdom	175 73 (men) 102 (women)	45,1 years	Combined Treatments	400	175 (44)	21	1-1	Cross-sectional
Vena et al.¹¹, 2014, United States	1257 528 (men) 729 (women)	51 years	Initial nonsurgical root canal therapy	1257	63 (5)	39	0,6-3,9	Cross-sectional
Von Arx and Kurt¹, 1999, Switzerland	NR	42 years	Periapical Surgery	43	10 (100)	0	1-1	Cohort

[TFN1] *1. Studies that included patients with comorbidities; 2. Studies involving individuals who did not undergo endodontic treatment or who were treated endodontically and reported pain in less than 6 months of endodontic therapy; 3. Studies with no pain assessment or that did not exclude odontogenic pain diagnosis; 4. Secondary studies, letters, books, conference abstracts, case reports, case series, case-control studies, opinion articles, technical articles, guidelines, randomized or non-randomized methods, and clinical trials; 5. Studies with unavailable full texts, even after requesting it from the authors.

Prevalence of persistent pain after endodontic treatment: a systematic review and meta-analysis

Abstract