Granules |
Flow |
Cai et al., 2013Cai L, Farber L, Zhang D, Li F, Farabaugh J. A new methodology for high drug loading wet granulation formulation. Int J Pharm. 2013;441(1-2):790-800.
|
Granules |
Bulk, tapped and true densities |
Chevalier et al., 2010Chevalier E, Viana M, Cazalbou S, Makein L, Dubois J, Chulia D. Ibuprofen-loaded calcium phosphate granules: Combination of innovative characterization methods to relate mechanical strength to drug location. Acta Biomaterialia. 2010;6(1):266-274.
|
Granules (HME)* |
True density |
Dong et al., 2008Dong Z, Chatterji A, Sandhu H, Choi DS, Chokshi H, Shah N. Evaluation of solid state properties of solid dispersions prepared by hot-melt extrusion and solvent co-precipitation. Int J Pharm. 2008;355(1-2):141-149.; Yeung, Rein, 2015Yeung CW, Rein H. Hot-melt extrusion of sugar-starch-pellets. Int J Pharm. 2015;493(1-2):390-403.
|
Granules |
Bulk and tapped densities; Hausner ratio |
Eckert, Pein; Breitkreutz, 2014Eckert C, Pein M, Breitkreutz J. Lean production of taste improved lipidic sodium benzoate formulations. Eur J Pharm Biopharm. 2014;88(2):455-461.
|
Granules (HME)* |
Bulk and tapped densities; compressibility index |
Grycze et al., 2011Grycze A, Schminke S, Maniruzzaman M, Beck J, Douramis D. Development and evaluation of orally disintegrating tablets (ODTs) containing ibuprofen granules prepared by hot melt extrusion. Colloid Surface B. 2011;86(2):275-284.
|
Granules |
Bulk and tapped densities; compressibility index and angle of repose |
Roohulaah et al., 2014 |
Granules |
Bulk and tapped densities |
Issa et al., 2012aIssa MG, Pessole L, Oliveira GGG, Ferraz HG. Revestimento de paracetamol para compressão direta em equipamento de leito fluidizado utilizando-se Kollicoat SR 30D(r) e Kollicoat Protect(r). Rev Bras Farm. 2012a;93(2):225-231.
|
Granules |
Bulk and tapped densities, compressibility index, Hausner ratio, angle of repose and flow rate |
Lamolha, Serra, 2007Lamolha MA, Serra CHR. Avaliação das propriedades de fluxo dos granulados e dissolução de comprimidos de hidroclorotiazida 50 mg obtidos por granulação úmida. Rev Bras Cien Farm. 2007;43(3):435-446.
|
Granules (MG)** |
Bulk and tapped densities and compressibility index |
Mašić et al., 2012Mašić I, Ilić I, Dreu R, Ibrić S, Parojčić J, Đurić Z. An investigation into the effects of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation. Int J Pharm. 2012;423(2):202-212.
|
Granules (MG)** |
Bulk and tapped densities, angle of repose and compressibility index |
Tran et al., 2011Tran HTT, Park JB, Hong K, Choi H, Han H, Lee J, et al. Preparation and characterization of pH-independent sustained release tablet containing solid dispersion granules of a poorly water-soluble drug. Int J Pharm. 2011;415(1-2):83-88.
|
Pellets |
Bulk and tapped densities, angle of repose and Hausner ratio |
Amrutkar, Chaudari, Patil, 2012Amrutkar PP, Chaudhari PD, Patil SB. Design and in vitro evaluation of multiparticulate floating drug delivery system of zolpidem tartarate. Colloid Surf B. 2012;89:182-187.
|
Pellets |
Bulk and tapped densities, Hausner ratio and compressibility index |
Beringhs et al., 2012Beringhs AO, Souza FM, Campos AM, Ferraz HG, Sonaglio D. Technological development of extract pellets by extrusion-spheronization. Rev Bras Farmacogn. 2012;23(1):160-168.
|
Pellets |
Bulk and tapped densities, angle of repose, Hausner ratio and compressibility index |
Chopra, Venkatesan, Betageri, 2013Chopra S, Venkatesan N, Betageri GV. Formulation of lipid bearing pellets as a delivery system for poorly soluble drugs. Int J Pharm. 2013;446(1-2):136-144.; Franc et al., 2015Franc A, Muselík J, Sabadková D, Neumann D. Preparation of pellets with controlled release of glucose as prevention of hypoglycaemia in paediatric patients. Eur J Pharm Sci. 2015;75:72-80.; Pagariya, Patil, 2013Pagariya TP, Patil SB. Development and optimization of multiparticulate drug delivery system of alfuzosin hydrochloride. Colloid Surface B. 2013;102:171-177.
|
Pellets |
Bulk and apparent densities |
Costa, Pais, Sousa, 2004Costa FO, Pais AACC, Sousa JJS. Analysis of formulation effects in the dissolution of ibuprofen pellets. Int J Pharm. 2004;270(1-2):9-19.
|
Pellets |
Bulk, tapped and apparent densities |
Ghanam, Hassan, Kleinebudde, 2010Ghanam D, Hassan I, Kleinebudde P. Compression behavior of k-carrageenan pellets. Int J Pharm. 2010;390(2):117-127.
|
Pellets |
True density |
Grassi et al., 2003Grassi M, Voinovich D, Moneguini M, Franceschinis E, Perissutti B, Filipovic-Grcic J. Preparation and evaluation of a melt pelletised paracetamol/ stearic acid sustained release delivery system. J Control Release. 2003;88(3):381-391.; Hiorth et al., 2013Hiorth M, Liereng L, Reinertsen R, Tho I. Formulation of bioadhesive hexylaminolevulinate pellets intended for photodynamic therapy in the treatment of cervical cancer. Int J Pharm. 2013;441(1-2):544-554.; Issa et al., 2012b |
Pellets |
Bulk and tapped densities, compressibility index and angle of repose |
Peng et al., 2015Peng T, Zhu C, Huang Y, Quan G, Huang L, Wu L, et al. Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients. Powder Technol. 2015;270(Part A):221-229.
|
Pellets |
Bulk, tapped and true densities, compressibility index, angle of repose and Hausner ratio |
Rabišková et al., 2012Rabišková M, Bautzová T, Gajdziok J, Dvořáčková K, Lamprecht A, Pellequer Y, et al. Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation. Int J Pharm. 2012;422(1-2):151-159.
|
Pellets |
True and effective densities |
Santos et al., 2005Santos H, Veiga F, Pina ME, Sousa JJ. Compaction, compression and drug release properties of diclofenac sodium and ibuprofen pellets comprising xanthan gum as a sustained release agent. Int J Pharm. 2005;295(1-2):15-27.
|
Pellets |
Bulk and tapped densities |
Sonaglio et al., 2012Sonaglio D, Beringhs AD, Porfírio A, Bataille B. On the factors influencing the extrusion strain, particle size and dissolution behavior of multiparticulate systems obtained by extrusion/spheronization. Powder Technol. 2012;230:54-62.
|
Minitablets |
True density |
Lopes et al., 2006Lopes CM, Lobo JMS, Pinto JF, Costa P. Directly compressed mini matrix tablets containing ibuprofen. Preparation and evaluation sustained release. Drug Dev Ind Pharm. 2006;32(1):95-106.
|