1 |
Oxygen loaded drug |
Hypoxic tissues, |
Fluid therapy |
- |
(Matsuki et al., 2014Matsuki N, Ishikawa T, Ichiba S, Shiba N, Ujike Y, Yamaguchi T. Oxygen supersaturated fluid using fine micro/nanobubbles. Int J Nanomed . 2014;9:4495.) |
Bladder |
Chemo therapy |
Mitomycin-C |
(Bhandari et al., 2018Bhandari P, Novikova G, Goergen CJ, Irudayaraj J. Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep. 2018;8(1):3112. ) |
Hypoxic tumor |
Epigenetic Regulation |
- |
(Bhandari et al., 2017Bhandari PN, Cui Y, Elzey BD, Goergen CJ, Long CM, Irudayaraj J. Oxygen nanobubbles revert hypoxia by methylation programming. Sci Rep . 2017;7(1):9268. ) |
2 |
Drug loaded nanobubble |
HeLa cells (Cervical cancer) |
Chemo therapy |
Doxorubicin |
(Deng et al., 2014Deng L, Li L, Yang H, Li L, Zhao F, Wu C, et al. Development and optimization of doxorubicin loaded poly (lactic-co-glycolic acid) nanobubbles for drug delivery into HeLa cells. J Nanosci Nanotechnol. 2014;14(4):2947-2954. ) |
MDA MB231 (Breast cancer tumors) |
Chemo therapy |
Doxorubicin |
(Gao et al., 2008Gao Z, Kennedy AM, Christensen DA, Rapoport NY. Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy. Ultrasonics. 2008;48(4):260-270.) |
Monoclonal anti-HLA-G antibodies |
Chemo therapy |
Methotrexate |
(Zhang et al., 2014Zhang X, Zheng Y, Wang Z, Huang S, Chen Y, Jiang W, et al. Methotrexate-loaded PLGA nanobubbles for ultrasound imaging and Synergistic Targeted therapy of residual tumor during HIFU ablation. Biomaterials. 2014;35(19):5148-5161. ) |
HepG2 cells (Hepatocellular carcinoma cells) |
Chemo therapy |
Sorafenib |
(Misra et al., 2015Misra SK, Ghoshal G, Jensen TW, Ray PS, Burdette EC, Pan D. Bi-modal cancer treatment utilizing therapeutic ultrasound and an engineered therapeutic nanobubble. RSC Adv. 2015;5(78):63839-63845. ) |
LS 174 T cells (Human colon adenocarcinoma) |
Chemo therapy |
Porphyrins chemical pigment |
(Bosca et al., 2018Bosca F, Bielecki PA, Exner AA, Barge A. Porphyrin-Loaded Pluronic Nanobubbles: A New US-Activated Agent for Future Theranostic Applications. Bioconjug Chem. 2018;29(2):234-240. ) |
HL60/ADM cells (adriamycin-resistant cell line) |
Chemo therapy |
Doxorubicin and Ciclosporin A |
(Ding, Patel, Zhang, 2018Ding S, Patel N, Zhang H. Ciclosporin A as a Reversal Agent Against Concurrent Multidrug Resistance in Tumors with Nanobubbles. J Biomed Nanotechnol. 2018;14(1):190-197. ) |
Tumorous cells in lungs cancer |
Chemo therapy |
Pemetrexed and pazopanib |
(Şanlıer et al., 2018Sanlier SH, Ak G, Yılmaz H, Unal A, Bozkaya UF, Taniyan G, et al. Development Of Ultrasound-Triggered And Magnetic Targeted Nanobubble System For Dual-Drug Delivery . J Pharm Sci . 2018;108(3): DOI:10.1016/j.xphs.2018.10.030. https://doi.org/10.1016/j.xphs.2018.10.0...
) |
3 |
Nanobubbles based Gene delivery system |
COS7 cell line |
Nonviral gene delivery |
pDNA |
(Cavalli et al., 2012Cavalli R, Bisazza A, Trotta M, Argenziano M, Civra A, Donalisio M, et al. New chitosan nanobubbles for ultrasound-mediated gene delivery: preparation and in vitro characterization. Int J Nanomed. 2012;7:3309. ) |
MCF-7 (human breast cancer) |
Chemo therapy |
Doxorubicin and P-gp siRNA |
(Yang et al., 2015bYang H, Deng L, Li T, Shen X, Yan J, Zuo L, et al. Multifunctional PLGA nanobubbles as theranostic agents: combining doxorubicin and P-gp siRNA co-delivery into human breast cancer cells and ultrasound cellular imaging. J Biomed Nanotechnol . 2015b;11(12):2124-2136. ) |
Gliomas |
siRNA transfection |
Anti-apoptosis gene sirtuin 2 (SIRT2) |
(Yin et al., 2013Yin T, Wang P, Li J, Zheng R, Zheng B, Cheng D, et al. Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. Biomaterials. 2013;34(18):4532-4543. ) |
4 |
Targeted (Site specific) nanobubble |
Human epidermal growth factor receptor type 2 (HER2) |
Inhibits overexpression of HER2 gene by anti-ErbB2 Affibody |
Biotinylated anti-ErbB2 Affibody® |
(Yang et al., 2015aYang H, Cai W, Xu L, Lv X, Qiao Y, Li P, et al. Nanobubble-Affibody: Novel ultrasound contrast agents for targeted molecular ultrasound imaging of tumor. Biomaterials. 2015a;37:279-288.) |
HepG2 cell |
Chemo therapy |
siRNA (BCL-2) and Paclitaxel |
(Yin et al., 2014Yin T, Wang P, Li J, Wang Y, Zheng B, Zheng R, et al. Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes. Biomaterials. 2014;35(22):5932-5943. ) |
Nucleus pulposus cells in spinal intervertebral disc |
Anticatabolic and cell apoptosis |
Resveratrol |
(Shen et al., 2018Shen J, Zhuo N, Xu S, Song Z, Hu Z, Hao J, et al. Resveratrol delivery by ultrasound-mediated nanobubbles targeting nucleus pulposus cells. Nanomedicine . 2018;13(12):1433-1446. ) |
HepG2 cells (Hepatocellular carcinoma cells) |
Antiangiogenetic medicine |
Apatinib |
(Tian et al., 2018Tian Y, Liu Z, Zhang L, Zhang J, Han X, Wang Q, et al. Apatinib-loaded lipid nanobubbles combined with ultrasound-targeted nanobubble destruction for synergistic treatment of HepG2 cells in vitro. OncoTargets Ther. 2018;11:4785. ) |