| Prostate cancer |
AR-ubiquitin-mediated degradation through E3 ligase Mdm2 |
AR |
Aberrent expressed in prostate cancer |
(Liuet al., 2013aLiu T, Li Y, Gu H, Zhu G, Li J, Cao L, et al. p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). J Biol Chem. 2013a;288(5):3359-69.) |
|
|
miR-23a-PAK6-LIMK1 |
miR-23a/LIMK1 |
|
(Caiet al., 2015Cai S, Chen R, Li X, Cai Y, Ye Z, Li S, et al. Downregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway. Oncotarget. 2015;6(6):3904-17.) |
|
|
miR-328-PAK6 |
miR-328 |
|
(Liuet al., 2015aLiu C, Zhang L, Huang Y, Lu K, Tao T, Chen S, et al. MicroRNA328 directly targets p21activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity. Mol Med Rep. 2015a;12(5):7389-95.) |
| Colon cancer |
|
miR-429 |
Promotion of cell
migration and invasion |
(Tianet al., 2015Tian X, Wei Z, Wang J, Liu P, Qin Y, Zhong M. MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling. Oncol Rep. 2015;34(2):707-14.) |
| Lung cancer (NSCLC) |
|
|
Promotion of cell
proliferation, migration
and invasion |
(Rajaet al., 2016Raja R, Sahasrabuddhe NA, Radhakrishnan A, Syed N, Solanki HS, Puttamallesh VN, et al. Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells. Oncotarget. 2016;7(38):61229-61245.) |
| HCC |
|
|
Aberrently expressed in HCC |
(Chenet al., 2014Chen H, Miao J, Li H, Wang C, Li J, Zhu Y, et al. Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma. J Surg Res. 2014;189(1):81-8.; Liuet al., 2015bLiu W, Liu Y, Liu H, Zhang W, Fu Q, Xu J, et al. Tumor suppressive function of p21-activated kinase 6 in hepatocellular carcinoma. J Biol Chem. 2015b;290(47):28489-501.) |
| Clear cell Renal cell carcinoma |
|
|
Associated with unfavorable OS (P = 0.001) and RFS
(P = 0.001) |
(Liuet al., 2014Liu W, Liu H, Liu Y, Xu L, Zhang W, Zhu Y, et al. Prognostic significance of p21-activated kinase 6 expression in patients with clear cell renal cell carcinoma. Ann Surg Oncol. 2014;21(Suppl 4):S575-83.) |
| Breast cancer |
|
|
Over-expressed in breast cancer cells |
(Kauret al., 2008Kaur R, Yuan X, Lu ML, Balk SP. Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate. 2008;68(14):1510-6.) |
| Gastric cancer |
|
|
Over-expressed in gastric cancer |
(Jianget al., 2017Jiang Y, Liu W, Li T, Hu Y, Chen S, Xi S, et al. Prognostic and predictive value of p21-activated kinase 6 Associated support vector machine classifier in gastric cancer treated by 5-fluorouracil/oxaliplatin chemotherapy. EBioMedicine. 2017;22:78-88.) |
| Thyroid cancer |
|
|
Expressed in normal and malignant thyroid tissues |
(McCarty et al., 2010McCarty SK, Saji M, Zhang X, Jarjoura D, Fusco A, Vasko VV, et al. Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion. Endocr Relat Cancer. 2010;17(4):989-99.) |
