Polycystic ovarian syndrome: temporal characterization of the induction and reversion process in an experimental model

Síndrome do ovário policístico: caracterização termporal do processo de indução e reversão em um modelo experimental

Numerous experimental models have been developed for the study of the polycystic ovarian syndrome in the rat. In the present study, the syndrome was induced by exposure to constant light. The process was evaluated during its induction and also during its reversion. The estral cycle was analyzed through the vaginal cytology; reproductive parameters were evaluated by mating, as well as the ovarian morphology. All the animals developed the syndrome after 13 weeks of permanent light. The histologic characteristics of the ovaries, at week 15, were similar to those observed in the polycystic ovarian syndrome in human and other species. After regression of the syndrome, there was not difference in any of the evaluated reproductive parameters, when compared with the control group.

Histopathology; Ovary; PCOD; Polycystic ovarian syndrome; Rat


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