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Use of isoflurane in capuchin monkeys (Cebus apella - Cebidae, Primata)

This study was performed in order to evaluate both clinical and anesthesiological responses during isoflurane anesthesia at 1 MAC and 1.5 MAC in capuchin monkeys. Therefore, ten healthy animals (7 males and 3 females), with an average weight of 3.1 ± 0.8 kg were premedicated with ketamine and atropine and induced with isoflurane. They were maintained with isoflurane at 1 MAC for 30 minutes and at 1.5 MAC for 30 minutes more. The cardiovascular and respiratory parameters were measured every 5 minutes and the pH, blood gases and oxygen saturation at each 10 minutes, from inicial (T0) to final time (T30) at both concentrations. The data were submitted to non-parametric Wilcoxon test statistical analysis (p < 0.05). A decreased in body temperature was observed at both isoflurane concentrations. Although no cardiac arrhythmias could be observed, the heart rate decreased at 1.5 MAC. However there were no changes in blood arterial pressure at any concentration. Isoflurane produced a dose-dependent depression in both tidal and minute volumes, whereas there was no significant change in respiratory rate. The pH, PaO2, PaCO2 and SaO2 didn’t change significantly at both concentrations.

Primates; Anesthesia; Cebus apella; Isoflurane

Faculdade de Medicina Veterinária e Zootecnia / Universidade de São Paulo Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária Armando de Salles Oliveira, 05508-270 São Paulo SP Brazil, Tel.: +55 11 3091-7636, Fax: +55 11 3031-3074 / 3091-7672 / 3091-7678 - São Paulo - SP - Brazil