Taneja et al., 2018, India |
Non randomized clinical trial |
n = 11426 |
6 to 12 months |
Calcarea phosphoricum 6x |
Tablet twice a day regularly for 12 months (6 to 12 months) |
Fever, colic, running nose, irritability, crankiness, crankiness, restlessness, no sleep, refusal to eat food, green stools, diarrhea, yellow stool. |
visited the household frequently by ASHAs (Accredited Social Health Activists) or were in contact with the parents by telephone or through a messenger to confirm health of the telephone or through a messenger to confirm health of the child. |
month to month |
ASHAs (n = 566) who had provided care to children gave their feedback: CP. 6X-330 ASHAs responded that CP helped in easy teething |
Children responded favorably to the medicines given by ASHAs at the time of diarrhea/URTI episodes, and ASHAs expressed satisfaction with the program. |
Central Council for Research in Homoeopathy, an autonomous body of the Ministry of AYUSH, Government of India. |
None declared |
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41 ASHAs : it reduced complaints associated with teething 195 responded CP eased teething as well as reduced associated complaints. |
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515/581 ASHAs responded:the six medicines IMPROVE: (Symptoms of teething such as increased salivation, irritability, and gum swelling |
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Ferrum phosphoricum 3X, |
2 tablets 4x/day for maximum 3 days (Child with fever) |
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307/581 ASHAs responded: six medicines IMPROVE : (Diarrhea) |
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Magnesium phosphoricum (mp) 6x |
2 tablets dissolved in hot water for 1 to maximum 2 days (child with colic) |
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11/581 ASHAs responded:the six medicines NO EFFECT |
Taneja et al., 2018, India |
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Belladonna 30C |
3 pills 4x/day for maximum 3 days (Child with running nose, fever) |
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month to month |
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Children responded favorably to the medicines given by ASHAs at the time of diarrhea/URTI episodes, and ASHAs expressed satisfaction with the program. |
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Non randomized clinical trial |
n = 11426 |
6 to 12 months |
Chamomilla 30C |
3 pills 4x/day for maximum 3 days (Child with irritability, crankiness, restlessness, no sleep, refusal to eat food, green stools) |
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Podophyllum 30c |
3 pills 4x/day for maximum 3 days. (Child with diarrhea, yellow, offensive stool) |
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Jong et al., 2015, The Netherlands |
Randomized Open Comparative Clinical Trial |
n = 200 |
Infants < 12 months |
ChamBell 5: 02 tablets (Dentokind®; intervention group) |
ChamBell 5: 02 tablets containing: Belladonna D6, |
Unmotivated anxiety, gingival tenderness and appetite disorder, otalgy, stool softening, sleep-onset insomnia and frequent awakenings kin pallor, gingiva condition: hyperemia, swelling, hematoma and hyperemia around the mouth, drooling and hyperthermia. |
interview |
0 |
Individual signs improved after seven days of treatment: intervention(n=100) /control group(n=100):unmotivated anxiety (88%/79%), gingival tenderness (73%/55%) (p=0.0130), appetite disorder (83%/66%) (p=0.0107), otalgy (56%/18%), stool softening (75%/36%), sleep-onset insomnia (57%/54%) and frequent awakenings (74%/59%), skin pallor (33%/30%), gingival hyperemia (91%/ 75%) (p = 0,0057); gingival swelling (59%/41%) (p = 0,0157); drooling (86%/83%), hyperemia around the mouth (51%/37%), hyperthermia(82%/86%). |
ChamBell 5: 02 tablets showed to be effective, safe and well tolerated. |
Deutsche Homöopathie-Union, DHU-Arzneimittel GmbH & Co. KG, Karlsruhe, Germany |
M. Jong was an employee of VSM Geneesmiddelen (sister company of Deutsche Homöopathie Union) from 2001 to 2008 P. Klement and J. Burkart are employees of Deutsche Homöopathie Union, DHU Arzneimittel GmbH & Co. KG, Karlsruhe, Germany.) |
Chamomilla D6, Ferrum |
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7 days |
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Jong et al., 2015, The Netherlands |
Randomized Open Comparative Clinical Trial |
n = 200 |
Infants < 12 months |
ChamBell 5: 02 tablets (Dentokind®; intervention group) |
phosphoricum D6, Hepar sulfuris D12 and Pulsatilla D6 (for seven days). |
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interview |
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ChamBell 5: 02 tablets showed to be effective, safe and well tolerated. |
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six tablets per day (acute symptoms). After symptoms reduced one tablet three times a day was administered |
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homeopathic suppositories |
Chamomilla recutita D1, Atropa bella donna D2, Solanum dulcamara |
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(ChamBell-5-02 tablets showed to be effective) |
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(Viburcol®; control group). |
D4, Plantago major D3, Pulsatilla pratensis D2, Calcium carbonicum |
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Hahnemanni D8.(seven days). For children aged up to six months: two suppositories a day. Children older than six months: four suppositories.) |
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Rosu et al., 2017, Romania |
Randomized, open-label, parallel-group (multicentre study) |
n = 54 |
3 to 36 months |
Group A: high molecular weight hyaluronic acid (HMWHA) gel :0.54% Hyaluronic Acid; (test group) |
Group A: massaging the surface around the teeth and applying locally a small amount of gel, up to a maximum of 6 times per day. |
Pain, swelling and redness, mouth spasm, sleep quality. |
Questionnaire and clinical examination Verbal Rating Scale: (VRS)Absent = 0; Moderate = 1; Intense = 2. |
baseline (T0), three days (T1) |
Pain |
The novel gel containing HMWHA proved to be an effective and safe alternativeto the anesthetic gel in the relief of teething symptoms in infants. |
Ricerfarma S.r.l. (www.ricerfarma.com) |
Have no financial interest |
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seven days (T2) |
T0 : test: 1.59 (0.50)/control:1.44 (0.51) p=0.2849 |
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14 days |
T1:test: 1.18 (0.62)/control:1.7 (0.47) p=0.0018 |
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(T3) |
T2:test:0.10 (0.33)/control:0.86 (0.73) p<0.0001 |
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Swelling: T0: test:1.70 (0.47)/control: 1.56 (0.51) p=0.2686 T1:test: 1.44 (0.51)/control:1.63 (0.49) p=0.1796 T2:test: 0.39 (0.57)/control:0.91 (0.71) p=0.0087 |
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Redness: T0: test:1.63 (0.56)/control: 1.63 (0.49) p=0.8678 T1:test:1.19 (0.56) /control:1.70 (0.47) p=0.0009 T2:test: 0.13 (0.40)/control:1.01 (0.63) p<0.0001 |
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mouth spasm: T0 – T1 (p=0.1648); T0 – T2 (p=0.1184);T2-T3 (p=0.3363). |
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Sleep quality was better in the test group than in the control group at T1 (p=0.0171) and T2 (p=0.0016 |
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Group B: standard anesthetic gel: cetylpyridinium chloride and lidocaine hydrochloride (control group) |
Group B: massaging the surface around the teeth and applying locally a small amount of gel, up to a maximum 4 times per day. |
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Kazyukova et al., 2018, Russia |
Randomized clinical trial |
n = 63 |
6 months to 2,5 years |
Principal Group: Dantinorm Baby (Homeopathy -liquid) |
Principal Group: Dantinorm Baby :2/3 to 5 times(maximum) / 3 days (maximum, no more than 5 days). dripping content into the child's mouth (1 dose = 1 ml). The main components: chamomile (chamomilla vulgaris) reduces tantrum and body temperature; (phytolacca decandra) reduces nausea and inflamed gums; (rheum officinale) relieves digestion symptoms |
Pain and swelling of the gums |
Visits and parent's report |
Visit 1: initial inspection |
teething symptoms and their severity in the groups compared with initial examination before study therapy (visit 1) |
«Dantinorm Baby» drug, which is designed on the basis of plant substances, in a liquid dosage form. It has no contraindications, does not cause side effects, does not increase the pharmacological load on the growing organism, and can be recommended for wide use in pediatric practice. |
None declared |
Have no financial interest |
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Increased salivation |
Visit 2: 3rd to 5th day |
Dantinorm Baby : (%) (n=31) Pain and swelling of the gums (100%) /Increased salivation(100%)/ Wish to bite / bite(100%)/Irritability (96,8%)/Decreased appetite (77,4%)/Sound disorders (74,2%); Increased body temperature> 37 0 (61,3%)/Running nose (48,4%); Cough (48,4%)/Irritation of the skin around the mouth (35,5%);Increased stool (25,8%). |
Kazyukova et al., 2018, Russia |
Randomized clinical trial |
n = 63 |
6 months to 2,5 years |
Principal Group: Dantinorm Baby (Homeopathy -liquid) |
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Wish to bite / bite |
Visits and parent's report |
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Calgel : (%) (n=32) Pain and swelling of the gums(100%)/Increased salivation(100%)/Wish to bite / bite(100%)/Irritability (100%)/ Decreased appetite (81,3%)/Sound disorders (65,6%)/Increased body temperature> 37 0 (62,5%)/ Running nose (40,6%)/Cough (40,6%)/Irritation of the skin around the mouth (37,5%)/ Increased stool (28,1%) teething symptoms and their severity in the groups compared with initial examination before study therapy (visit 2): Pain and swelling of the gums(90,3%) /Increased salivation(90,3%)/ Wish to bite / bite(87,1%)/Irritability (58,1%)/Decreased appetite (35,5%)/Sound disorders (32,3%) -Increased body temperature> 37 0 (35,5%)/Running nose (35,5%) |
«Dantinorm Baby» drug, which is designed on the basis of plant substances, in a liquid dosage form. It has no contraindications, does not cause side effects, does not increase the pharmacological load on the growing organism, and can be recommended for wide use in pediatric practice. |
None declared |
Have no financial interest |
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Irritability |
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Decreased appetite |
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Sound disorders |
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Increased body temperature |
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Running nose |
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Cough |
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Irritation of the skin around the mouth |
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Increase sed stool |
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Adverse events: G control: 6/32 |
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Control Group: Calgel |
Control Group: Calgel applying the gel with your finger, gently massaging the inflamed gum; if necessary, reapply at intervals of at least 20min, but no more than 6 times / day, for 3 days. The main components: lidocaine hydrochloride and cetylpyridinium chloride |
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«Dantinorm Baby» drug, which is designed on the basis of plant substances, in a liquid dosage form. It has no contraindications, does not cause side effects, does not increase the pharmacological load on the growing organism, and can be recommended for wide use in pediatric practice. |
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Memarpour et al. / 2015 / Iran |
Non randomized clinical trial |
n = 254 |
8 to 36 months |
Cuddle therapy (n=53) |
Hug or cuddle the child. Activities to distract the child. |
Drooling, Diarrhea, lethargy, Loss of appetite, Lack of sleep, Gum irritation, chewing objects, Finger sucking, Irritability, Red and inflamed gums, Gingival pain, Crying. |
Questionnaire contained 27 items. Body temperature was measured; Body temperature was measured; and Intraoral examination (palpation). |
4 days before eruption, On the day of eruption and 3 days after eruption. |
Cuddle therapy (frequency of successful cases) Drooling (n=47), Lethargy (n=13), Loss of appetite (n= 21); Lack of sleep (n=41); Gum irritation (n=36); Chewing objects (n= 29); Finger sucking (n=26); Irritability(n=6); Red and inflamed gum(n=11); Gingival pain (n= 18); Crying (n=41). Pieces of ice (frequency of successful cases) |
Teething rings, cuddle therapy and rubbing the gums were the most effective methods to reduce symptoms. |
Vice Chancellory of Research of Shiraz University of Medical Science, Shiraz, Iran. |
No competing interests. |
Pieces of ice (n=50) |
Pieces of ice wrapped in a towel were placed on the gums and mucous membrane overlying the erupting teeth for 1 to 2 min. |
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Memarpour et al. / 2015 / Iran |
Non randomized clinical trial |
n = 254 |
8 to 36 months |
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Drooling, Diarrhea, lethargy, Loss of appetite, Lack of sleep, Gum irritation, chewing objects, Finger sucking, Irritability, Red and inflamed gums, Gingival pain, Crying. |
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Drooling (n=29); Lethargy (n=17); Loss of appetite (n=22); Lack of sleep (n=41); Gum irritation (n=36); Chewing objects (n= 39); Finger sucking (n=37); Irritability(n=6); Red and inflamed gum (n=29); Gengival pain(n=16); Crying (n=38). Teething rings (frequency of successful cases) |
Teething rings, cuddle therapy and rubbing the gums were the most effective methods to reduce symptoms. |
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Rubbing the child's gums (n=50) |
Massage for 1 to 2 min. |
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Drooling (n=47); Lethargy(n=11); Loss of appetite (n=17); Lack of sleep (n=40); Gum irritation (n=29); Chewing objects (n= 33); Finger sucking (n=40); Irritability (n=16); Red and inflamed gum(n=21); Gingival pain (n= 18); Crying (n=34). Food for chewing (frequency of successful cases) |
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Teething rings (n=51) |
Give the ring to the child to chew or bite on. |
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Drooling (n= 37); Lethargy (n=9); Loss of appetite (n= 31); Lack of sleep(n=32); Gum irritation (n=29); Finger sucking (n=23); Chewing objects(n=21); Irritability(n=16); Red and inflamed gum(n=15); Gengival pain(n=14); Crying (n=32). |
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Food for chewing (n=50) |
Pieces of a frozen fruit or vegetable. |
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