Postoperative pain behavior differs according to type of stimulus in ratsABSTRACT
BACKGROUND AND OBJECTIVES This study addressed the role of skin and deep tissue incisions in two different models of postoperative pain in rats, plantar incision and gastrocnemius incision models.
METHODS After approval from the Ethics Committee of the institution, male Wistar rats were used in two different experiments. One group of animals was used in the plantar incision model and divided in three groups: sham incision, skin incision and skin and muscle and fascia incision (deep tissue incision). Another group was used in the gastrocnemius incision model and divided into three other groups: sham incision, skin incision and muscle and fascia incision. The animals in the plantar incision model were assessed for paw withdrawal threshold, and the time spent by the animals in the gastrocnemius incision model in the running wheel was recorded
RESULTS Skin and skin + deep tissue plantar incisions increased hyperalgesia after mechanical stimulus in the paw. Hyperalgesia lasted in the skin group until the 3rd postoperative day (POD), in the skin + deep tissue incision group, hyperalgesia lasted until the 4th POD. Skin and skin + deep tissue groups were significantly different on the 1st, 2nd, 3rd and 4th POD. Time spent in the running wheel was lower in the skin + deep tissue group on the 1st and 2nd POD.
CONCLUSION Pain behavior elicited after mechanical stimulus in skin and deep tissue incision is more intense than skin incision in the plantar incision model, however, skin and skin + deep tissue incision elicited the same behavior in gastrocnemius incision model
Keywords:
Pain; Fascia; Hyperalgesia; Male; Postoperative; Rats; Skin; Wistar
HIGHLIGHTS
Acute postoperative pain is still very prevalent
The mechanisms need to be better studied
The roles of muscles and fasciae are very important in post-operative pain
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