Therapeutic potential of otological formulations composed from Triticum aestivum, Bixa orellana, Tris-EDTA and N-acetylcysteine in the treatment of canine otitis externa

Abstract

The objective was to evaluate the efficiency of three otological solutions based on plant extracts and adjuvants in treating canine otitis externa. Three different ear solutions were developed, composed of ethanolic extracts of Triticum aestivum, Bixa orellana, and Tris-EDTA, ethanolic extracts of Triticum aestivum, Bixa orellana, and N-acetylcysteine, and a combination of Triticum aestivum, Bixa orellana, N-acetylcysteine, and Tris-EDTA. A commercial product was used as the control. The study included 64 dogs diagnosed with otitis externa, randomly divided into four groups, treated once daily for seven days. Clinical signs of otalgia, pruritus, odor, erythema, and cerumen amount were evaluated on days D0, D3, and D7. Samples for bacterial, fungal cultures, and cytology were collected before and after treatments. Clinical signs were scored from 0 to 3, with a sum generated per animal and group during each evaluation day. All evaluated compounds effectively reduced clinical signs and microorganisms involved in canine external otitis cases.

Keywords:
adjuvants; plant extracts; otopathy; wheat; annatto