Nasit et al., 2012 (77. Nasit JG, Parikh B, Trivedi P, Shah M. Myoid (muscular) hamartoma
of the breast with chondroid metaplasia. Indian J Pathol Microbiol.
2012;55(1):121-2.) |
45, F |
Lump |
9 |
NR |
Well-circumscribed, dense mass |
NR |
Few mammary lobules and ducts, with a fibrous stroma |
Myoid hamartoma |
Vimentin +, SMA +, Desmin +, ER, PR
+Cytokeratin -, S-100 - CD34 - |
No (one-year follow-up) |
Mizuta et al., 2012 (88. Mizuta N, Sakaguchi K, Mizuta M, Imai A, Nakatsukasa K, Morita M,
et al. Myoid hamartoma of the breast that proved difficult to diagnose: a case
report. World J Surg Oncol. 2012;10:12.) |
38, F |
Lump |
2.8 |
Well-demarcated, hypoechoic lesion with slightly irregular
margins |
Well-demarcated, oval, isodense mass that was partly indistinct
(BI-RADS-4) |
Well-circumscribed mass with high signal intensity, showing
strong enhancement and a microlobulated margin. Dynamic
contrast-enhanced imaging demonstrated rapid enhancement of the
mass |
Fibroadenoma with focal mastopathic change |
Myoid hamartoma |
SMA +, Vimentin +, Desmin + Cytokeratin -, S-100
- |
NR |
Kai et al., 2012 (99. Kai M, Tada K, Tamura M, Gomi N, Horii R, Akiyama F, et al.
Breast cancer associated with mammary hamartoma. Breast Cancer.
2012;19(2):183-6, http://dx.doi.org/10.1007/s12282-009-0147-3. http://dx.doi.org/10.1007/s12282-009-014...
) |
70, F |
Lump |
3.2 |
Irregular hypoechoic tumor both within and external to
hamartoma |
Typical hamartoma |
Suspected malignancy |
NR |
HamartomaDCISIDC |
NR |
NR |
Uchôa et al., 2010 (1010. Uchoa DM, Cruz DB, Schaefer PG, Pegas KL, Cambruzzi E.
Myofibroblastoma arising in mammary hamartoma: a case report. Patholog Res Int.
2010;2010: 4 pages. Article ID726829.) |
59, F |
Lump |
2.5 |
NR |
NR |
NR |
NR |
NR |
Vimentin +, Desmin +, CD34 + Calponin +,
bcl-2 +,SMA -Actin -,S-100 -,CD99 -,CD10 - |
NR |
Choi et al., 2010 (1111. Choi N, Ko ES. Invasive ductal carcinoma in a mammary hamartoma:
case report and review of the literature. Korean J Radiol.
2010;11(6):687-91.) |
72, F |
Lump |
9 |
Spiculated, non-parallel hypoechoic nodule within hamartoma |
Typical hamartoma with focal asymmetry |
Suspected malignancy |
NR |
HamartomaIDC |
NR |
No (2-year follow-up) |
Ko et al.,2010 (1212. Ko MS, Jung WS, Cha ES, Choi HJ. A rare case of recurrent myoid
hamartoma mimicking malignancy: imaging appearances. Korean J Radiol.
2010;11(6):683-6.) |
43, F |
Lump |
2.5 |
Irregular isoechoic mass with a microlobulated margin |
Two oval isodense masses with a partially obscured margins in
the left subareolar area |
Suspected malignancy |
Mammary lobules, ducts, and stromaNo malignant component |
Myoid hamartoma |
Vimentin +, SMA +,CD34 +,S-100 - |
Recurrence in the first year |
Gupta et al., 2010 (1313. Gupta SS, Singh O, Hastir A, Arora G, Sabharwal G, Mishra H.
Breast hamartoma with intrathoracic extension in a 13-year-old boy.
J Cancer Res Ther. 2010;6(1):86-8,
http://dx.doi.org/10.4103/0973-1482.63559. http://dx.doi.org/10.4103/0973-1482.6355...
) |
13, M |
Lump |
10 |
Solid heterogeneous mass with internal echogenic zones |
NR |
NR |
Non-diagnostic |
Hamartoma |
NR |
No (14-month follow-up) |
Kajo et al., 2010 (1414. Kajo K, Zubor P, Danko J. Myoid (Muscular) Hamartoma of the
Breast: Case Report and Review of the Literature. Breast Care (Basel).
2010;5(5):331-4, http://dx.doi.org/10.1159/000321341. http://dx.doi.org/10.1159/000321341...
) |
46, F |
Lump |
17 |
NR |
NR |
NR |
Fibroadenoma |
Myoid hamartoma |
Desmin +, SMA +,Caldesmon +,CD34 -,S-100 -,CD 10
- |
NR |
Khoo et al., 2009 (1515. Khoo JJ, Alwi RI, Abd-Rahman I. Myoid hamartoma of breast with
chondroid metaplasia: a case report. Malays J Pathol.
2009;31(1):77-80.) |
46, F |
Lump |
9 |
Solid breast mass |
Dense, well-encapsulated mass with no calcifications |
NR |
Fibroadenoma |
Myoid hamartoma,chondroid differentiation |
Vimentin +,Myoglobin +, SMA + Desmin +,CD34
+,Cytokeratin -,S-100 - |
NR |
Pervatikar et al., 2009 (1616. Pervatikar SK, Rao R, Dinesh US, Parameswaraiah S. Large mammary
hamartoma with focal invasive ductal carcinoma. Indian J Pathol
Microbiol. 2009;52(2):249-51.) |
25, F |
Lump |
15 |
NR |
NR |
NR |
Malignant |
HamartomaIDC |
|
No (one-year follow-up) |
Lee WF et al., 2008 (1717. Lee WF, Sheen-Chen SM, Chi SY, Huang HY, Ko SF. Hamartoma of the
breast: an underrecognized disease? Tumori.
2008;94(1):114-5.) |
48, F |
Lump |
4.5 |
NR |
Typical hamartoma |
NR |
NR |
Hamartoma |
NR |
NR |
Hernanz et al., 2008 (1818. Hernanz F, Vega A, Palacios A, Fleitas MG. Giant hamartoma of
the breast treated by the mammaplasty approach. ANZ J Surg.
2008;78(3):216-7.) |
29, F |
Breast asymmetry |
14 |
NR |
Well-circumscribed mass |
NR |
Core biopsy; hamartoma |
Hamartoma |
NR |
NR |
Stafyla et al., 2007 (1919. Stafyla V, Kotsifopoulos N, Grigoriadis K, Bakoyiannis CN, Peros
G, Sakorafas GH. Myoid hamartoma of the breast: a case report and review of the
literature. Breast J. 2007;13(1):85-7,
http://dx.doi.org/10.1111/j.1524-4741.2006.00369.x. http://dx.doi.org/10.1111/j.1524-4741.20...
) |
60, F |
Lump |
11.5 |
Solid mass |
Dense, well-defined mass |
NR |
NR |
Myoid hamartoma |
NR |
No (4-year follow-up) |
Murat et al., 2007 (2020. Murat A, Ozdemir H, Yildirim H, Poyraz AK, Ozercan R. Hamartoma
of the breast. Australas Radiol. 2007;51 Spec No.:B37-9,
http://dx.doi.org/10.1111/j.1440-1673.2007.01818.x. http://dx.doi.org/10.1111/j.1440-1673.20...
) |
42, F |
No complaints, MMG, US |
5 |
Smooth-edged,solid mass lesion with heterogeneous
echogenicity |
Smooth-edged, heterogeneous,oval opacity and surrounding
radiolucency |
Mass lesion with heterogeneous intensity |
Core biopsy; hamartoma |
Hamartoma |
NR |
NR |
Murugesan et al., 2006 (2121. Murugesan JR, Joglekar S, Valerio D, Bradley S, Clark D, Jibril
JA. Myoid hamartoma of the breast: case report and review of the literature.
Clin Breast Cancer. 2006;7(4):345-6,
http://dx.doi.org/10.3816/CBC.2006.n.050. http://dx.doi.org/10.3816/CBC.2006.n.050...
) |
45, F |
Breast pain, MMG, US |
1.6 |
Irregular hypoechoic, lobulated, ill-defined borders |
Irregular, partly ill-defined lesion with no
microcalcification |
NR |
Core biopsy; myoid hamartoma |
Myoid hamartoma |
SMA +,Desmin +, S-100 - |
NR |
Borges da Silva et al., 2006 (2222. da Silva BB, Rodrigues JS, Borges US, Pires CG, Pereira da Silva
RF. Large mammary hamartoma of axillary supernumerary breast tissue. Breast.
2006;15(1):135-6,
http://dx.doi.org/10.1016/j.breast.2005.03.004. http://dx.doi.org/10.1016/j.breast.2005....
) |
33, F |
Axillary mass |
10 |
Compatible with the diagnosis of a voluminous nodule |
NP |
NP |
NP |
Hamartoma |
NP |
No (2-year follow-up) |
Ruiz-Tovar et al., 2006 (2323. Ruiz-Tovar J, Reguero-Callejas ME, Arano-Bermejo JI,
Gonzalez-Palacios F, Cabanas-Navarro L. [Mammary hamartoma]. Cir Esp.
2006;79(3):186-8,
http://dx.doi.org/10.1016/S0009-739X(06)70848-X. http://dx.doi.org/10.1016/S0009-739X(06)...
) |
43.2 (mean), F, 8 cases |
Lump (all) |
7.25 (mean) |
Heterogeneous mass with hypoechogenic areas inside (22. Fisher CJ, Hanby AM, Robinson L, Millis RR. Mammary
hamartoma—a review of 35 cases. Histopathology. 1992;20(2):99-106,
http://dx.doi.org/10.1111/j.1365-2559.1992.tb00938.x. http://dx.doi.org/10.1111/j.1365-2559.19...
) |
Well-circumscribed masses combining radiolucent and dense areas
(all) |
NR |
Benign (55. Arrigoni MG, Dockerty MB, Judd ES. The identification and
treatment of mammary hamartoma. Surg Gynecol Obstet.
1971;133(4):577-82.)Core
biopsy;hamartoma (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Incisional biopsy; hamartoma (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Hamartoma (all) |
NR |
Recurrence in 1 patient (after 6 months) |
Kuroda et al., 2006 (2424. Kuroda N, Goishi K, Ohara M, Hirouchi T, Mizumo K, Nakagawa K.
Bilateral hamartoma arising in axillary accessory mammary glands. Case report.
APMIS. 2006;114(1):77-8.) |
57, F |
Bilateral axillary lump |
3.5, 3.3 |
NP |
NP |
NP |
NP |
Bilateral hamartoma |
NP |
NP |
Breucq et al., 2005 (2525. Breucq C, Verfaillie G, Perdaens C, Vermeiren B, Stadnik T.
Lobular carcinoma located in a breast hamartoma. Breast J.
2005;11(6):508-9,
http://dx.doi.org/10.1111/j.1075-122X.2005.00144.x. http://dx.doi.org/10.1111/j.1075-122X.20...
) |
42, F |
Lump |
2 |
Well-circumscribed, oval heterogeneous nodule |
Denser aspect |
NP |
NR |
Myoid hamartoma,LCIS |
NR |
NR |
Barbaros et al., 2005 (2626. Barbaros U, Deveci U, Erbil Y, Budak D. Breast hamartoma: a case
report. Acta Chir Belg. 2005;105(6):658-9.) |
36, F |
Lump |
15 |
Fibroadenolipoma |
Fibroadenolipoma |
NR |
NR |
Hamartoma |
NR |
NR |
Gatti et al., 2005 (2727. Gatti G, Mazzarol G, Simsek S, Viale G. Breast hamartoma: a case
report. Breast Cancer Res Treat. 2005;89(2):145-7,
http://dx.doi.org/10.1007/s10549-004-1656-6. http://dx.doi.org/10.1007/s10549-004-165...
) |
43, F |
Lump |
4.5 |
Oval shape, well-circumscribed margins and internal
echogenicity |
No sign of disease |
NR |
NR |
Hamartoma |
NR |
NR |
Giannotti Filho et al., 2004 (2828. Filho OG, Gordan AN, Mello Rde A, Neto CS, Heinke T. Myoid
hamartomas of the breast: report of 3 cases and review of the literature.
Int J Surg Pathol. 2004;12(2):151-3.) |
51 (mean), F, 3 cases |
Lump |
1.3 (mean) |
NR |
Well-circumscribed lump |
NR |
NR |
Myoid hamartoma |
SMA +, Vimentin +, Desmin +, S-100 - |
NR |
Lee et al., 2003 (2929. Lee EH, Wylie EJ, Bourke AG, Bastiaan De Boer W. Invasive ductal
carcinoma arising in a breast hamartoma: two case reports and a review of the
literature. Clin Radiol. 2003;58(1):80-3,
http://dx.doi.org/10.1053/crad.2003.1133. http://dx.doi.org/10.1053/crad.2003.1133...
) |
66.5 (mean), F, 2 cases |
Axillary mass (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)MMG
(11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
5.5 (mean) |
Well-defined hypoechoic nodule within hamartoma (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)NP (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Typical hamartoma |
NR |
Malignant (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)NP (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Hamartoma, DCIS, IDC (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Hamartoma, IDC (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
NR |
No (6-month follow-up) (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)No (5-year follow-up) (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Baron et al., 2003 (3030. Baron M, Ladonne JM, Gravier A, Picquenot JM, Berry M. Invasive
lobular carcinoma in a breast hamartoma. Breast J. 2003;9(3):246-8,
http://dx.doi.org/10.1046/j.1524-4741.2003.09313.x. http://dx.doi.org/10.1046/j.1524-4741.20...
) |
54 |
Lump |
5 |
NR |
Well-circumscribed, oval, mixed fatty and fibroglandular
lesion |
NR |
Benign epithelial cells |
HamartomaILC |
High ERLow PR |
NR |
Tse et al., 2002 (3131. Tse GM, Law BK, Pang LM, Cheung HS. Ductal carcinoma in situ
arising in mammary hamartoma. J Clin Pathol. 2002;55(7):541-2,
http://dx.doi.org/10.1136/jcp.55.7.541. http://dx.doi.org/10.1136/jcp.55.7.541...
) |
50 (mean), F2 cases |
Lump |
2 (mean) |
Well-defined lobulated mass (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)NP (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
NP |
NR |
NP (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Cellular atypia
(11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Hamartoma, DCIS (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Hamartoma, DCIS, mucinous carcinoma (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
NR |
No (5-year follow-up) (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)No (4-year follow-up) (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Kuroda et al., 2002 (3232. Kuroda N, Sugimoto T, Numoto S, Enzan H. Microinvasive lobular
carcinoma associated with intraductal spread arising in a mammary hamartoma.
J Clin Pathol. 2002;55(1):76-7,
http://dx.doi.org/10.1136/jcp.55.1.76. http://dx.doi.org/10.1136/jcp.55.1.76...
) |
53, F |
Lump |
6 |
İsoechoic solid mass with capsule suspected to be a
lipomatous tumor |
Circumscribed mass with a thin pseudocapsule, no
microcalcification, and no spiculation |
NR |
NR |
Hamartoma, ILC |
Β-catenin - |
NR |
Herbert et al., 2002 (3333. Herbert M, Sandbank J, Liokumovich P, Yanai O, Pappo I, Karni T,
et al. Breast hamartomas: clinicopathological and immunohistochemical studies of
24 cases. Histopathology. 2002;41(1):30-4,
http://dx.doi.org/10.1046/j.1365-2559.2002.01429.x. http://dx.doi.org/10.1046/j.1365-2559.20...
) |
48 (mean)F, 24 cases |
Lump (all) |
2-5 (range) |
NR |
NR |
NR |
NR |
HamartomaFocal apocrine metaplasia (in a few
cases)Pseudoangiomatous hyperplasia (77. Nasit JG, Parikh B, Trivedi P, Shah M. Myoid (muscular) hamartoma
of the breast with chondroid metaplasia. Indian J Pathol Microbiol.
2012;55(1):121-2.) |
NR |
NR |
Tse et al., 2002 (3434. Tse GM, Law BK, Ma TK, Chan AB, Pang LM, Chu WC, et al.
Hamartoma of the breast: a clinicopathological review. J Clin Pathol.
2002;55(12):951-4, http://dx.doi.org/10.1136/jcp.55.12.951. http://dx.doi.org/10.1136/jcp.55.12.951...
) |
38 (mean)F, 24 cases |
Lump (2323. Ruiz-Tovar J, Reguero-Callejas ME, Arano-Bermejo JI,
Gonzalez-Palacios F, Cabanas-Navarro L. [Mammary hamartoma]. Cir Esp.
2006;79(3):186-8,
http://dx.doi.org/10.1016/S0009-739X(06)70848-X. http://dx.doi.org/10.1016/S0009-739X(06)...
)Breast asymmetry
(11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
3.8 (mean) |
Typical hamartoma (1818. Hernanz F, Vega A, Palacios A, Fleitas MG. Giant hamartoma of
the breast treated by the mammaplasty approach. ANZ J Surg.
2008;78(3):216-7.) |
Mixed fibrous adipose tissueOvoid-rounded, well-circumscribed
masses of mixed heterogeneous density with a mottled center and
thin smooth capsules with peripheral radiolucent zones |
Typical hamartoma (44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.)Well
capsulated, with a dark smooth rim; ovoid in shape, with
internal heterogeneity and heterogeneous gadolinium
enhancement |
Hamartoma (1111. Choi N, Ko ES. Invasive ductal carcinoma in a mammary hamartoma:
case report and review of the literature. Korean J Radiol.
2010;11(6):687-91.)Non-diagnostic (33. Prym P. Pseudoadenome, Adenome und Mastome der weiblithen
Brustdrfise; Studien fiber die Entstehung umschriebener adenom∼ hnlicher
Herde in der Mamma und fiber die Nachahmung der Brustdrfisengewebes durch echte
Adenome und Fibroadenome. Beitr Pathol Anat. 1928;81:1-44.)Benign (77. Nasit JG, Parikh B, Trivedi P, Shah M. Myoid (muscular) hamartoma
of the breast with chondroid metaplasia. Indian J Pathol Microbiol.
2012;55(1):121-2.)More cellular (44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.) |
HamartomaPseudoangiomatous changes (88. Mizuta N, Sakaguchi K, Mizuta M, Imai A, Nakatsukasa K, Morita M,
et al. Myoid hamartoma of the breast that proved difficult to diagnose: a case
report. World J Surg Oncol. 2012;10:12.)Mild epithelial hyperplasia (1010. Uchoa DM, Cruz DB, Schaefer PG, Pegas KL, Cambruzzi E.
Myofibroblastoma arising in mammary hamartoma: a case report. Patholog Res Int.
2010;2010: 4 pages. Article ID726829.)Cystic changes (88. Mizuta N, Sakaguchi K, Mizuta M, Imai A, Nakatsukasa K, Morita M,
et al. Myoid hamartoma of the breast that proved difficult to diagnose: a case
report. World J Surg Oncol. 2012;10:12.)Apocrine metaplasia
(44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.)Adenosis (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)DCIS (33. Prym P. Pseudoadenome, Adenome und Mastome der weiblithen
Brustdrfise; Studien fiber die Entstehung umschriebener adenom∼ hnlicher
Herde in der Mamma und fiber die Nachahmung der Brustdrfisengewebes durch echte
Adenome und Fibroadenome. Beitr Pathol Anat. 1928;81:1-44.)Stromal hyalinization
(33. Prym P. Pseudoadenome, Adenome und Mastome der weiblithen
Brustdrfise; Studien fiber die Entstehung umschriebener adenom∼ hnlicher
Herde in der Mamma und fiber die Nachahmung der Brustdrfisengewebes durch echte
Adenome und Fibroadenome. Beitr Pathol Anat. 1928;81:1-44.) |
NR |
Recurrence in 1 patient (after 10 months) |
Ravakhah et al., 2001 (3535. Ravakhah K, Javadi N, Simms R. Hamartoma of the breast in a man:
first case report. Breast J. 2001;7(4):266-8,
http://dx.doi.org/10.1046/j.1524-4741.2001.20079.x. http://dx.doi.org/10.1046/j.1524-4741.20...
) |
36, M |
Lump |
3 |
NR |
NR |
NR |
Non-diagnostic |
Myoid Hamartoma |
NR |
NR |
Weinzweig et al., 2001 (3636. Weinzweig N, Botts J, Marcus E. Giant hamartoma of the breast.
Plast Reconstr Surg. 2001;107(5):1216-20,
http://dx.doi.org/10.1097/00006534-200104150-00019. http://dx.doi.org/10.1097/00006534-20010...
) |
15, F |
Breast asymmetry |
27 |
Mixed echogenic pattern |
NR |
NR |
NR |
Hamartoma (lobular proliferation) |
NR |
NR |
Wahner-Roedler et al., 2001 (3737. Wahner-Roedler DL, Sebo TJ, Gisvold JJ. Hamartomas of the
breast: clinical, radiologic, and pathologic manifestations. Breast J.
2001;7(2):101-5,
http://dx.doi.org/10.1046/j.1524-4741.2001.007002101.x. http://dx.doi.org/10.1046/j.1524-4741.20...
) |
50 (mean), F, 35 cases |
Lump (1818. Hernanz F, Vega A, Palacios A, Fleitas MG. Giant hamartoma of
the breast treated by the mammaplasty approach. ANZ J Surg.
2008;78(3):216-7.)MMG (1818. Hernanz F, Vega A, Palacios A, Fleitas MG. Giant hamartoma of
the breast treated by the mammaplasty approach. ANZ J Surg.
2008;78(3):216-7.) |
3.2 (mean) |
Solid hypoechoic lesion (1212. Ko MS, Jung WS, Cha ES, Choi HJ. A rare case of recurrent myoid
hamartoma mimicking malignancy: imaging appearances. Korean J Radiol.
2010;11(6):683-6.)Solid hypoechoic with definite cystic areas
(55. Arrigoni MG, Dockerty MB, Judd ES. The identification and
treatment of mammary hamartoma. Surg Gynecol Obstet.
1971;133(4):577-82.) |
Irregular margin (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Indistinct margin (44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.)Water density (2121. Murugesan JR, Joglekar S, Valerio D, Bradley S, Clark D, Jibril
JA. Myoid hamartoma of the breast: case report and review of the literature.
Clin Breast Cancer. 2006;7(4):345-6,
http://dx.doi.org/10.3816/CBC.2006.n.050. http://dx.doi.org/10.3816/CBC.2006.n.050...
)Mixed density (22. Fisher CJ, Hanby AM, Robinson L, Millis RR. Mammary
hamartoma—a review of 35 cases. Histopathology. 1992;20(2):99-106,
http://dx.doi.org/10.1111/j.1365-2559.1992.tb00938.x. http://dx.doi.org/10.1111/j.1365-2559.19...
) |
NR |
Core biopsy; benign (33. Prym P. Pseudoadenome, Adenome und Mastome der weiblithen
Brustdrfise; Studien fiber die Entstehung umschriebener adenom∼ hnlicher
Herde in der Mamma und fiber die Nachahmung der Brustdrfisengewebes durch echte
Adenome und Fibroadenome. Beitr Pathol Anat. 1928;81:1-44.) |
Hamartoma (all)Calcifications (44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.)Ductal hyperplasia (99. Kai M, Tada K, Tamura M, Gomi N, Horii R, Akiyama F, et al.
Breast cancer associated with mammary hamartoma. Breast Cancer.
2012;19(2):183-6, http://dx.doi.org/10.1007/s12282-009-0147-3. http://dx.doi.org/10.1007/s12282-009-014...
) |
NR |
NR |
Takeuchi et al., 2001 (3838. Takeuchi M, Kashiki Y, Shibuya C, Yamamoto S, Kitamura F, Nagao
Y, et al. A case of muscular hamartoma of the breast. Breast Cancer.
2001;8(3):243-5, http://dx.doi.org/10.1007/BF02967516. http://dx.doi.org/10.1007/BF02967516...
) |
74, F |
Lump |
1.8 |
Oval-shaped hypoechoic mass with slightly irregular margin |
Well marginated and oval-shaped isodense nodule with no
microcalcification |
NR |
NR |
Myoid hamartoma |
SMA +,S-100 -, Myoglobin -, Keratin -, Vimentin - |
NR |
Mester et al., 2000 (3939. Mester J, Simmons RM, Vazquez MF, Rosenblatt R. In situ and
infiltrating ductal carcinoma arising in a breast hamartoma. AJR
Am J Roentgenol. 2000;175(1):64-6,
http://dx.doi.org/10.2214/ajr.175.1.1750064. http://dx.doi.org/10.2214/ajr.175.1.1750...
) |
59, F |
Lump |
7 |
NR |
Circumscribed, predominantly fatty mass. Multiple macro- and
microcalcifications were contained in the mass |
NR |
Nondiagnostic |
HamartomaDCIS |
NR |
NR |
Chiacchio et al., 1999 (4040. Chiacchio R, Panico L, D'Antonio A, Delrio P, Bifano D,
Avallone M, et al. Mammary hamartomas: an immunohistochemical study of ten
cases. Pathol Res Pract. 1999;195(4):231-6,
http://dx.doi.org/10.1016/S0344-0338(99)80039-9. http://dx.doi.org/10.1016/S0344-0338(99)...
) |
40.4 (mean)F, 10 cases |
Lump |
5.4 (mean) |
NR |
Nodular densities |
NR |
NR |
HamartomaPseudoangiomatous hyperplasia |
CK +,S-100 +,Vimentin + |
NR |
Blomqvist et al., 1997 (4141. Blomqvist L, Malm M, Fernstad R. Hamartoma of the breast:
surgical treatment and reconstruction. Case report. Scand J Plast
Reconstr Surg Hand Surg. 1997;31(4):365-9,
http://dx.doi.org/10.3109/02844319709008985. http://dx.doi.org/10.3109/02844319709008...
) |
33.5 (mean), F, 2 cases |
Lump (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Breast asymmetry
(11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
NR |
NP |
NP |
NP |
Benign hamartoma (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Benign (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Hamartoma |
NP |
NR |
Anani et al., 1996 (4242. Anani PA, Hessler C. Breast hamartoma with invasive ductal
carcinoma. Report of two cases and review of the literature. Pathol Res Pract.
1996;192(12):1187-94,
http://dx.doi.org/10.1016/S0344-0338(96)80149-X. http://dx.doi.org/10.1016/S0344-0338(96)...
) |
65.5 (mean), F, 2 cases |
Lump, skin ulcer (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Lump
(11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
6 (mean) |
Hypoechoic absorbing lesion suggestive of carcinoma (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Typical hamartoma with irregular opacity containing
microcalcifications (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Typical hamartoma with spiculated mass (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
NR |
NR |
HamartomaIDC (all) |
NR |
NR |
Garfein et al., 1996 (4343. Garfein CF, Aulicino MR, Leytin A, Drossman S, Hermann G,
Bleiweiss IJ. Epithelioid cells in myoid hamartoma of the breast: a potential
diagnostic pitfall for core biopsies. Arch Pathol Lab Med.
1996;120(7):676-80.) |
50-59 (range), F, 6 cases |
Lump (33. Prym P. Pseudoadenome, Adenome und Mastome der weiblithen
Brustdrfise; Studien fiber die Entstehung umschriebener adenom∼ hnlicher
Herde in der Mamma und fiber die Nachahmung der Brustdrfisengewebes durch echte
Adenome und Fibroadenome. Beitr Pathol Anat. 1928;81:1-44.)MMG (33. Prym P. Pseudoadenome, Adenome und Mastome der weiblithen
Brustdrfise; Studien fiber die Entstehung umschriebener adenom∼ hnlicher
Herde in der Mamma und fiber die Nachahmung der Brustdrfisengewebes durch echte
Adenome und Fibroadenome. Beitr Pathol Anat. 1928;81:1-44.) |
1.1-7 (range) |
Solid lesion (44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.) |
Well-circumscribed lesion (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Heterogeneous radiodensity (44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.)Homogeneously radiodense (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)Slightly irregular border
(11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
NR |
Nondiagnostic (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Myoid Hamartoma |
Actin +,Desmin +,Vimentin +,Cytokeratin -, S-100
+ |
No (follow-up of 2-19 months) |
This study |
41.8 (mean), F, 27 cases |
Lump (2424. Kuroda N, Goishi K, Ohara M, Hirouchi T, Mizumo K, Nakagawa K.
Bilateral hamartoma arising in axillary accessory mammary glands. Case report.
APMIS. 2006;114(1):77-8.)Breast asymmetry
(33. Prym P. Pseudoadenome, Adenome und Mastome der weiblithen
Brustdrfise; Studien fiber die Entstehung umschriebener adenom∼ hnlicher
Herde in der Mamma und fiber die Nachahmung der Brustdrfisengewebes durch echte
Adenome und Fibroadenome. Beitr Pathol Anat. 1928;81:1-44.) |
3.9 (mean) |
Well-circumscribed, oval heterogeneous nodule (2323. Ruiz-Tovar J, Reguero-Callejas ME, Arano-Bermejo JI,
Gonzalez-Palacios F, Cabanas-Navarro L. [Mammary hamartoma]. Cir Esp.
2006;79(3):186-8,
http://dx.doi.org/10.1016/S0009-739X(06)70848-X. http://dx.doi.org/10.1016/S0009-739X(06)...
)Slightly irregular
margin(44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.) |
Typical hamartoma (55. Arrigoni MG, Dockerty MB, Judd ES. The identification and
treatment of mammary hamartoma. Surg Gynecol Obstet.
1971;133(4):577-82.)Malignant lesion (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Malignancy (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
Benign (44. Altermatt HJ, Gebbers JO, Laissue JA. Multiple hamartomas of the
breast. Appl Pathol. 1989;7(2):145-8.) |
Hamartoma (2626. Barbaros U, Deveci U, Erbil Y, Budak D. Breast hamartoma: a case
report. Acta Chir Belg. 2005;105(6):658-9.)Myoid
hamartoma (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)IDC (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
)LCIS (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
SMA + (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
),Desmin
+ (11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
), CD34 +
(11. Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J,
Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study
of 41 cases. Pathol Res Pract. 1994;190(4):362-71,
http://dx.doi.org/10.1016/S0344-0338(11)80408-5. http://dx.doi.org/10.1016/S0344-0338(11)...
) |
No recurrence to date |